Noninvasive prediction of fetal growth restriction using maternal plasma cell-free RNA: a case-control study

• Published in: BMC pregnancy and childbirth Vol. 25; no. 1; pp. 702 - 10
• Main Authors: Huang, Yihong, Wang, Ruizhi, Shen, Lixia, Kong, Lingyi, Chen, Peisong, Wang, Zilian, Li, Zhuyu
• Format: Journal Article
• Language: English
• Published: England BioMed Central 02.07.2025; BMC
• Subjects: Accuracy; Adult; BIN2; Biomarkers; Biomarkers - blood; Birth weight; Blood tests; Body mass index; Case-Control Studies; Cell-Free Nucleic Acids - blood; Cell-free RNA; Female; Fetal growth restriction; Fetal Growth Retardation - blood; Fetal Growth Retardation - diagnosis; Fetal Growth Retardation - genetics; Gene expression; Gene Expression Profiling; Genomics; Gestational age; Gestational diabetes; Humans; Machine learning; OAZ1; Performance evaluation; Placenta; Placenta - metabolism; Plasma; Predictive Value of Tests; Preeclampsia; Pregnancy; RHOA; Ultrasonic imaging; Womens health; United States > US; Guangzhou China; China; Cell-free RNA; BIN2; OAZ1; Fetal growth restriction; RHOA

Fetal growth restriction (FGR) is a significant concern due to its potential adverse outcomes for both mothers and infants. Cell-free RNA in maternal plasma has been suggested as a potential biomarker for pregnancy complications, but its effectiveness in predicting FGR remains uncertain. This study...