Azimilide pharmacokinetics and pharmacodynamics upon multiple oral dosing

• Published in: Biopharmaceutics & drug disposition Vol. 20; no. 2; pp. 59 - 68
• Main Authors: Corey, Alfred, Al-Khalidi, Hussein, Brezovic, Christopher, Marcello, Stephen, Parekh, Nikhil, Taylor, Kevin, Karam, Roger
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.03.1999; Wiley
• Subjects: Administration, Oral; Adolescent; Adult; Anti-Arrhythmia Agents - administration & dosage; Anti-Arrhythmia Agents - pharmacokinetics; Anti-Arrhythmia Agents - pharmacology; Antiarythmic agents; azimilide; Biological and medical sciences; Cardiovascular system; class III antiarrhythmic; Drug Administration Schedule; Female; Humans; Hydantoins; Imidazoles - administration & dosage; Imidazoles - pharmacokinetics; Imidazoles - pharmacology; Imidazolidines; Male; Medical sciences; multiple dosing; pharmacodynamics; pharmacokinetics; Pharmacology. Drug treatments; Piperazines - administration & dosage; Piperazines - pharmacokinetics; Piperazines - pharmacology; Multiple dose; Human; QT interval; Azimilide; Activity concentration relation; Oral administration; Electrocardiography; Antiarrhythmic agent; Normal; Pharmacokinetics; Dose activity relation

This study assessed steady‐state azimilide pharmacokinetics and pharmacodynamics in 119 healthy male and female volunteers. Parallel groups of 18–40‐year‐old subjects received doses of 35, 100, 150 or 200 mg day−1 for up to 14 days, with 1, 2 or 3 days of loading. Another group of >55‐year‐old su...