Investigation of pH and Temperature Profiles in the GI Tract of Fasted Human Subjects Using the Intellicap® System

• Published in: Journal of pharmaceutical sciences Vol. 104; no. 9; pp. 2855 - 2863
• Main Authors: Koziolek, Mirko, Grimm, Michael, Becker, Dieter, Iordanov, Ventzeslav, Zou, Hans, Shimizu, Jeff, Wanke, Christoph, Garbacz, Grzegorz, Weitschies, Werner
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2015; Elsevier Limited
• Subjects: Adult; Body Temperature - physiology; Capsule Endoscopes; Chemistry, Pharmaceutical; clinical trials; Colon - metabolism; Colon - physiology; controlled release; Drug Delivery Systems; Fasting - metabolism; Female; Gastric Emptying; Gastrointestinal Tract - physiology; gastrointestinal transit; Gastrointestinal Transit - physiology; Humans; Hydrogen-Ion Concentration; intestinal secretion/transport; Intestine, Small - metabolism; Intestine, Small - physiology; Male; oral drug delivery; site-specific delivery; solid dosage form; Telemetry; Thermometry - instrumentation; transit time; Young Adult; drug delivery systems; controlled release; oral drug delivery; transit time; pH; site-specific delivery; clinical trials; intestinal secretion/transport; solid dosage form; gastrointestinal transit

Gastrointestinal (GI) pH and temperature profiles under fasted-state conditions were investigated in two studies with each 10 healthy human subjects using the IntelliCap® system. This telemetric drug delivery device enabled the determination of gastric emptying time, small bowel transit time, and co...