Immunity induced by the radiation‐attenuated schistosome vaccine
SUMMARY As a paradigm for the development of a vaccine against human schistosomiasis, the radiation‐attenuated (RA) vaccine has enabled the dissection of different immune responses as putative effector mechanisms. This review considers advances made in the past, and updates our knowledge with refere...
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Published in | Parasite immunology Vol. 27; no. 7‐8; pp. 271 - 280 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Science Ltd
01.07.2005
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Subjects | |
Online Access | Get full text |
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Summary: | SUMMARY
As a paradigm for the development of a vaccine against human schistosomiasis, the radiation‐attenuated (RA) vaccine has enabled the dissection of different immune responses as putative effector mechanisms. This review considers advances made in the past, and updates our knowledge with reference to recent studies that have provided new information relevant particularly to the early innate events after vaccination, and to the nature of the protective effector mechanism. Priming of a protective response by RA larvae is a highly co‐ordinated series of events starting in the skin, draining lymph nodes and lungs, leading to the development of various effector responses, ranging from Th1‐associated cell‐mediated activity, to anti‐parasitic antibodies, all of which contribute to the elimination of challenge larvae to varying extents. In this respect, the RA vaccine elicits a multifaceted immune response, from which we can derive valuable insights relevant to the future design of novel delivery systems and adjuvants for recombinant and subunit vaccines. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 0141-9838 1365-3024 |
DOI: | 10.1111/j.1365-3024.2005.00764.x |