The gut microbiota may be a novel pathogenic mechanism in loosening of orthopedic implants in rats

• Published in: The FASEB journal Vol. 34; no. 11; p. 14302
• Main Authors: Moran, Meghan M, Wilson, Brittany M, Li, Jun, Engen, Phillip A, Naqib, Ankur, Green, Stefan J, Virdi, Amarjit S, Plaas, Anna, Forsyth, Christopher B, Keshavarzian, Ali, Sumner, Dale R
• Format: Journal Article
• Language: English
• Published: United States 01.11.2020
• Subjects: Animals; Gastrointestinal Microbiome; Inflammation - etiology; Inflammation - pathology; Male; Osteolysis - etiology; Osteolysis - pathology; Prostheses and Implants - adverse effects; Prosthesis-Related Infections - etiology; Prosthesis-Related Infections - pathology; Rats; implant fixation; orthopedics; bone volume; gut microbiome; implant

Particles released from implants cause inflammatory bone loss, which is a key factor in aseptic loosening, the most common reason for joint replacement failure. With the anticipated increased incidence of total joint replacement in the next decade, implant failure will continue to burden patients. T...