Enhanced long-term potentiation and impaired learning in mice lacking alternative exon 33 of CaV1.2 calcium channel

• Published in: Translational psychiatry Vol. 12; no. 1; p. 1
• Main Authors: Navakkode, Sheeja, Zhai, Jing, Wong, Yuk Peng, Li, Guang, Soong, Tuck Wah
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 10.01.2022; Nature Publishing Group
• Subjects: 631/378/1595/2167; 64/60; 692/699; 9/30; Behavioral Sciences; Biological Psychology; Bipolar disorder; Medicine; Medicine & Public Health; Neurosciences; Pharmacotherapy; Psychiatry; Schizophrenia

The CACNA1C (calcium voltage-gated channel subunit alpha 1 C) gene that encodes the Ca V 1.2 channel is a prominent risk gene for neuropsychiatric and neurodegenerative disorders with cognitive and social impairments like schizophrenia, bipolar disorders, depression and autistic spectrum disorders (...