Inositol Phosphoglycan P-Type in Preeclampsia: A Novel Marker?

• Published in: Hypertension (Dallas, Tex. 1979) Vol. 49; no. 1; pp. 84 - 89
• Main Authors: Williams, Philip J., Gumaa, Khalid, Scioscia, Marco, Redman, Christopher W., Rademacher, Thomas W.
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Heart Association, Inc 01.01.2007; Hagerstown, MD Lippincott
• Subjects: Adult; Antihypertensive agents; Arterial hypertension. Arterial hypotension; Biological and medical sciences; Biomarkers - urine; Blood and lymphatic vessels; Cardiology. Vascular system; Cardiovascular system; Case-Control Studies; Clinical manifestations. Epidemiology. Investigative techniques. Etiology; Enzyme-Linked Immunosorbent Assay - methods; Female; Humans; Inositol Phosphates - urine; Medical sciences; Pharmacology. Drug treatments; Polysaccharides - urine; Pre-Eclampsia - etiology; Pre-Eclampsia - urine; Pregnancy; Risk Factors; Human; Inositol; Pregnancy disorders; Hepatoprotector; Biological marker; B-Vitamins; Case control study; Screening test; Insulin; Pregnancy toxemia; Case study; Placenta; Preeclampsia; Risk factor; inositol phosphoglycan; Diagnosis; insulin resistance; Comparative study

A state of insulin resistance has been demonstrated in active preeclampsia, and women with clinical evidence of insulin resistance are at higher risk to develop this syndrome during pregnancy. Recently, inositol phosphoglycan P-type, a putative second messenger of insulin action, has been implicated...