Inhibition of tyrosinase by cherimoya pericarp proanthocyanidins: Structural characterization, inhibitory activity and mechanism

• Published in: Food research international Vol. 100; no. Pt 1; pp. 731 - 739
• Main Authors: Chai, Wei-Ming, Lin, Mei-Zhen, Wang, Ying-Xia, Xu, Kai-Li, Huang, Wen-Yang, Pan, Dan-Dan, Zou, Zheng-Rong, Peng, Yi-Yuan
• Format: Journal Article
• Language: English
• Published: Canada Elsevier Ltd 01.10.2017
• Subjects: Annonaceae - chemistry; Cherimoya; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - metabolism; Enzyme Inhibitors - pharmacology; ESI-QTOF-MS; Fluorescence quenching; Fruit - chemistry; Molecular docking; Molecular Docking Simulation; Monophenol Monooxygenase - antagonists & inhibitors; Monophenol Monooxygenase - chemistry; Monophenol Monooxygenase - metabolism; Proanthocyanidins; Proanthocyanidins - chemistry; Proanthocyanidins - metabolism; Proanthocyanidins - pharmacology; Spectrometry, Fluorescence; Spectrometry, Mass, Electrospray Ionization; Tyrosinase inhibitors; Tyrosinase inhibitors; ESI-QTOF-MS; Cherimoya; Molecular docking; Proanthocyanidins; Fluorescence quenching

In this study, the structure of proanthocyanidins purified from cherimoya (Annona squamosa) pericarp was analyzed by ESI-QTOF-MS and HPLC analyses. The result indicated that these compounds were procyanidin-type proanthocyanidins, consisting mainly of (epi)catechin units linked b y B-type interflava...