Lung-Derived Exosomal miR-483-3p Regulates the Innate Immune Response to Influenza Virus Infection

• Published in: The Journal of infectious diseases Vol. 217; no. 9; pp. 1372 - 1382
• Main Authors: Maemura, Tadashi, Fukuyama, Satoshi, Sugita, Yukihiko, Lopes, Tiago J S, Nakao, Tomomi, Noda, Takeshi, Kawaoka, Yoshihiro
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 11.04.2018
• Subjects: Animals; Bronchoalveolar Lavage Fluid; Cell Line; Female; Gene Expression Regulation - immunology; Immunity, Innate - physiology; Lung - metabolism; Membrane Proteins - genetics; Membrane Proteins - metabolism; Mice; Mice, Inbred C57BL; MicroRNAs - genetics; MicroRNAs - metabolism; NF-kappa B; Orthomyxoviridae - immunology; Orthomyxoviridae Infections - immunology; Orthomyxoviridae Infections - virology; Tetraspanin 28 - genetics; Tetraspanin 28 - metabolism; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - metabolism; influenza virus; microRNA; innate immunity; exosome

Abstract Exosomes regulate cell–cell communication by transferring functional proteins and RNAs between cells. Here, to clarify the function of exosomes during influenza virus infection, we characterized lung-derived exosomal microRNAs (miRNAs). Among the detected miRNAs, miR-483-3p was present at h...