Classification of IDH wild-type glioblastoma tumorspheres into low- and high-invasion groups based on their transcriptional program

• Published in: British journal of cancer Vol. 129; no. 7; pp. 1061 - 1070
• Main Authors: Park, Junseong, Shim, Jin-Kyoung, Lee, Mirae, Kim, Dokyeong, Yoon, Seon-Jin, Moon, Ju Hyung, Kim, Eui Hyun, Park, Jeong-Yoon, Chang, Jong Hee, Kang, Seok-Gu
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 19.10.2023; Nature Publishing Group UK
• Subjects: Brain cancer; Genotype & phenotype; Glioblastoma; Invasiveness; Medical prognosis; Metastases; Phenotypes; Prognosis; Proteomes; siRNA; Stat3 protein; Transcription factors; Transcriptomes; Tumors

Glioblastoma (GBM), one of the most lethal tumors, exhibits a highly infiltrative phenotype. Here, we identified transcription factors (TFs) that collectively modulate invasion-related genes in GBM. The invasiveness of tumorspheres (TSs) were quantified using collagen-based 3D invasion assays. TF ac...