Zebrafish sex differentiation and gonad development: A review on the impact of environmental factors

• Published in: Aquatic toxicology Vol. 191; pp. 141 - 163
• Main Authors: Santos, Dércia, Luzio, Ana, Coimbra, Ana M.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2017
• Subjects: 17α-ethinylestradiol; Animals; EDCs; Endocrine Disruptors - toxicity; Environmental sex determination; Genetic sex determination; Gonads - drug effects; Gonads - growth & development; Hypoxia; Sex Characteristics; Sex Ratio; Temperature; Water Pollutants, Chemical - chemistry; Water Pollutants, Chemical - toxicity; Zebrafish - growth & development; Temperature; Environmental sex determination; 17α-ethinylestradiol; Genetic sex determination; EDCs

Zebrafish (Danio rerio) is extensively used in research; however the mechanisms that control this species sex determination are still poorly understood. In the latest decades, it has been established that zebrafish sex is determined by genetic factors on a polygenic basis, as various candidate genes...