Global cellular responses to β-methyl-amino-l-alanine (BMAA) by olfactory ensheathing glial cells (OEC)

• Published in: Toxicon (Oxford) Vol. 99; pp. 136 - 145
• Main Authors: Chiu, Alexander S., Braidy, Nady, Marçal, Helder, Welch, Jeffrey H., Gehringer, Michelle M., Guillemin, Gilles J., Neilan, Brett A.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2015
• Subjects: Agglomeration; Amino Acids, Diamino - toxicity; Animals; Apoptosis - drug effects; Bacterial Toxins - toxicity; Biotechnology; Cell Line; Cells, Cultured; Channels; Excitatory Amino Acid Agonists - toxicity; G2 Phase - drug effects; Gene expression; Gene Expression Profiling; Gene Expression Regulation - drug effects; Genes; Genomics; Glial biology; Kinetics; Nerve Tissue Proteins - agonists; Nerve Tissue Proteins - antagonists & inhibitors; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Neurodegenerative diseases; Neuroglia - cytology; Neuroglia - drug effects; Neuroglia - metabolism; Neurotoxins - toxicity; Olfactory Bulb - cytology; Proteins; Proteomics; Rats; Rats, Wistar; Receptors; β-Methyl-amino-l-alanine; Glial biology; β-Methyl-amino-l-alanine; Neurodegenerative diseases; Genomics; Proteomics

This study utilised a proteomics approach to identify any differential protein expression in a glial cell line, rat olfactory ensheathing cells (OECs), treated with the cyanotoxin β-methylamino-l-alanine (BMAA). Five proteins of interest were identified, namely Rho GDP-dissociation inhibitor 1 (RhoG...