Airway “Resistotypes” and Clinical Outcomes in Bronchiectasis

• Published in: American journal of respiratory and critical care medicine Vol. 210; no. 1; pp. 47 - 62
• Main Authors: Mac Aogáin, Micheál, Xaverius Ivan, Fransiskus, Jaggi, Tavleen Kaur, Richardson, Hollian, Shoemark, Amelia, Narayana, Jayanth Kumar, Dicker, Alison J., Koh, Mariko Siyue, Lee, Ken Cheah Hooi, Thun How, Ong, Poh, Mau Ern, Chin, Ka Kiat, Hou, Albert Lim Yick, Ser Hon, Puah, Low, Teck Boon, Abisheganaden, John Arputhan, Dimakou, Katerina, Digalaki, Antonia, Kosti, Chrysavgi, Gkousiou, Anna, Hansbro, Philip M., Blasi, Francesco, Aliberti, Stefano, Chalmers, James D., Chotirmall, Sanjay H.
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 01.07.2024
• Subjects: Adult; Aged; Airway management; Anti-Bacterial Agents - therapeutic use; Antibiotics; Antimicrobial agents; Bronchiectasis - drug therapy; Bronchiectasis - microbiology; Bronchiectasis - physiopathology; Clinical outcomes; Cross-Sectional Studies; Female; Humans; Longitudinal Studies; Male; Metagenomics - methods; Microbiota; Microbiota - genetics; Middle Aged; Multidrug resistant organisms; Original; Prospective Studies; Pseudomonas aeruginosa - genetics; Pseudomonas Infections - complications; Pseudomonas Infections - drug therapy; Sputum - microbiology; resistome; resistotype; bronchiectasis; microbiome; metagenomics

Chronic infection and inflammation shapes the airway microbiome in bronchiectasis. Utilizing whole-genome shotgun metagenomics to analyze the airway resistome provides insight into interplay between microbes, resistance genes, and clinical outcomes. To apply whole-genome shotgun metagenomics to the...