Intoxication due to Δ9-tetrahydrocannabinol is characterized by disrupted prefrontal cortex activity

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 49; no. 9; pp. 1481 - 1490
• Main Authors: Karunakaran, Keerthana Deepti, Pascale, Michael, Ozana, Nisan, Potter, Kevin, Pachas, Gladys N., Evins, A. Eden, Gilman, Jodi M.
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.08.2024; Springer International Publishing
• Subjects: Acute intoxication; Adolescent; Adult; Cannabinoid Receptor Agonists - administration & dosage; Cannabinoid Receptor Agonists - pharmacology; Cannabinoid receptors; Cannabinoids; Cannabis; Cross-Over Studies; Double-Blind Method; Dronabinol - administration & dosage; Dronabinol - pharmacology; Female; Heart rate; Heart Rate - drug effects; Humans; Infrared spectroscopy; Intoxication; Male; Marijuana; Middle Aged; Neural networks; Neuroimaging; Placebos; Prefrontal cortex; Prefrontal Cortex - drug effects; Spectroscopy, Near-Infrared; Tetrahydrocannabinol; THC; Young Adult

Neural states of impairment from intoxicating substances, including cannabis, are poorly understood. Cannabinoid 1 receptors, the main target of Δ9-tetrahydrocannabinol (THC), the primary intoxicating cannabinoid in cannabis, are densely localized within prefrontal cortex; therefore, prefrontal brai...