Inflammatory bowel disease:Pathogenesis

Inflammatory bowel disease(IBD),including Crohn’s disease and ulcerative colitis,is characterized by chronic relapsing intestinal inflammation.It has been a worldwide health-care problem with a continually increasing incidence.It is thought that IBD results from an aberrant and continuing immune res...

Full description

Saved in:

Bibliographic Details
Published in	World journal of gastroenterology : WJG Vol. 20; no. 1; pp. 91 - 99
Main Author	Zhang, Yi-Zhen
Format	Journal Article
Language	English
Published	United States Baishideng Publishing Group Co., Limited 07.01.2014
Subjects	Adaptive Immunity Animals bowel colitis Croh disease Environment Genetic Predisposition to Disease Humans Immunity, Innate Inflammatory Inflammatory Bowel Diseases - etiology Inflammatory Bowel Diseases - genetics Inflammatory Bowel Diseases - immunology Inflammatory Bowel Diseases - microbiology Intestines - immunology Intestines - microbiology Prognosis Risk Factors Topic Highlight Ulcerative Inflammatory bowel disease Microbial factors Pathogenesis Genetics Immune responses Crohn’s disease Ulcerative colitis
Online Access	Get full text

Cover

Loading…

Abstract	Inflammatory bowel disease(IBD),including Crohn’s disease and ulcerative colitis,is characterized by chronic relapsing intestinal inflammation.It has been a worldwide health-care problem with a continually increasing incidence.It is thought that IBD results from an aberrant and continuing immune response to the microbes in the gut,catalyzed by the genetic susceptibility of the individual.Although the etiology of IBD remains largely unknown,it involves a complex interaction between the genetic,environmental or microbial factors and the immune responses.Of the four components of IBD pathogenesis,most rapid progress has been made in the genetic study of gut inflammation.The latest internationally collaborative studies have ascertained 163susceptibility gene loci for IBD.The genes implicated in childhood-onset and adult-onset IBD overlap,suggesting similar genetic predispositions.However,the fact that genetic factors account for only a portion of overall disease variance indicates that microbial and environmental factors may interact with genetic elements in the pathogenesis of IBD.Meanwhile,the adaptive immune response has been classically considered to play a major role in the pathogenesis of IBD,as new studies in immunology and genetics have clarified that the innate immune response maintains the same importance in inducing gut inflammation.Recent progress in understanding IBD pathogenesis sheds lights on relevant disease mechanisms,including the innate and adaptive immunity,and the interactions between genetic factors and microbial and environmental cues.In this review,we provide an update on the major advances that have occurred in above areas.
AbstractList	Inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, is characterized by chronic relapsing intestinal inflammation. It has been a worldwide health-care problem with a continually increasing incidence. It is thought that IBD results from an aberrant and continuing immune response to the microbes in the gut, catalyzed by the genetic susceptibility of the individual. Although the etiology of IBD remains largely unknown, it involves a complex interaction between the genetic, environmental or microbial factors and the immune responses. Of the four components of IBD pathogenesis, most rapid progress has been made in the genetic study of gut inflammation. The latest internationally collaborative studies have ascertained 163 susceptibility gene loci for IBD. The genes implicated in childhood-onset and adult-onset IBD overlap, suggesting similar genetic predispositions. However, the fact that genetic factors account for only a portion of overall disease variance indicates that microbial and environmental factors may interact with genetic elements in the pathogenesis of IBD. Meanwhile, the adaptive immune response has been classically considered to play a major role in the pathogenesis of IBD, as new studies in immunology and genetics have clarified that the innate immune response maintains the same importance in inducing gut inflammation. Recent progress in understanding IBD pathogenesis sheds lights on relevant disease mechanisms, including the innate and adaptive immunity, and the interactions between genetic factors and microbial and environmental cues. In this review, we provide an update on the major advances that have occurred in above areas. Inflammatory bowel disease(IBD),including Crohn’s disease and ulcerative colitis,is characterized by chronic relapsing intestinal inflammation.It has been a worldwide health-care problem with a continually increasing incidence.It is thought that IBD results from an aberrant and continuing immune response to the microbes in the gut,catalyzed by the genetic susceptibility of the individual.Although the etiology of IBD remains largely unknown,it involves a complex interaction between the genetic,environmental or microbial factors and the immune responses.Of the four components of IBD pathogenesis,most rapid progress has been made in the genetic study of gut inflammation.The latest internationally collaborative studies have ascertained 163susceptibility gene loci for IBD.The genes implicated in childhood-onset and adult-onset IBD overlap,suggesting similar genetic predispositions.However,the fact that genetic factors account for only a portion of overall disease variance indicates that microbial and environmental factors may interact with genetic elements in the pathogenesis of IBD.Meanwhile,the adaptive immune response has been classically considered to play a major role in the pathogenesis of IBD,as new studies in immunology and genetics have clarified that the innate immune response maintains the same importance in inducing gut inflammation.Recent progress in understanding IBD pathogenesis sheds lights on relevant disease mechanisms,including the innate and adaptive immunity,and the interactions between genetic factors and microbial and environmental cues.In this review,we provide an update on the major advances that have occurred in above areas. Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is characterized by chronic relapsing intestinal inflammation. It has been a worldwide health-care problem with a continually increasing incidence. It is thought that IBD results from an aberrant and continuing immune response to the microbes in the gut, catalyzed by the genetic susceptibility of the individual. Although the etiology of IBD remains largely unknown, it involves a complex interaction between the genetic, environmental or microbial factors and the immune responses. Of the four components of IBD pathogenesis, most rapid progress has been made in the genetic study of gut inflammation. The latest internationally collaborative studies have ascertained 163 susceptibility gene loci for IBD. The genes implicated in childhood-onset and adult-onset IBD overlap, suggesting similar genetic predispositions. However, the fact that genetic factors account for only a portion of overall disease variance indicates that microbial and environmental factors may interact with genetic elements in the pathogenesis of IBD. Meanwhile, the adaptive immune response has been classically considered to play a major role in the pathogenesis of IBD, as new studies in immunology and genetics have clarified that the innate immune response maintains the same importance in inducing gut inflammation. Recent progress in understanding IBD pathogenesis sheds lights on relevant disease mechanisms, including the innate and adaptive immunity, and the interactions between genetic factors and microbial and environmental cues. In this review, we provide an update on the major advances that have occurred in above areas.Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is characterized by chronic relapsing intestinal inflammation. It has been a worldwide health-care problem with a continually increasing incidence. It is thought that IBD results from an aberrant and continuing immune response to the microbes in the gut, catalyzed by the genetic susceptibility of the individual. Although the etiology of IBD remains largely unknown, it involves a complex interaction between the genetic, environmental or microbial factors and the immune responses. Of the four components of IBD pathogenesis, most rapid progress has been made in the genetic study of gut inflammation. The latest internationally collaborative studies have ascertained 163 susceptibility gene loci for IBD. The genes implicated in childhood-onset and adult-onset IBD overlap, suggesting similar genetic predispositions. However, the fact that genetic factors account for only a portion of overall disease variance indicates that microbial and environmental factors may interact with genetic elements in the pathogenesis of IBD. Meanwhile, the adaptive immune response has been classically considered to play a major role in the pathogenesis of IBD, as new studies in immunology and genetics have clarified that the innate immune response maintains the same importance in inducing gut inflammation. Recent progress in understanding IBD pathogenesis sheds lights on relevant disease mechanisms, including the innate and adaptive immunity, and the interactions between genetic factors and microbial and environmental cues. In this review, we provide an update on the major advances that have occurred in above areas.
Author	Yi-Zhen Zhang Yong-Yu Li
AuthorAffiliation	Department of Pathophysiology,Tongji University School of Medicine
Author_xml	– sequence: 1 givenname: Yi-Zhen surname: Zhang fullname: Zhang, Yi-Zhen
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/24415861$$D View this record in MEDLINE/PubMed
BookMark	eNp1kc1P3DAQxS1EBcu2R64VN3rJdvyV2D0gIUQLElJ74G5NkknWKLEhzoL475sAiwAJSx4f_N77WX4HbDfEQIwdcljJQpmfDzft6l7AyvOV5TtsIQS3mTAKdtmCAxSZlaLYZwcp3QAIKbXYY_tCKa5Nzhfs-DI0HfY9jnF4PCrjA3VHtU-EiX79w3EdWwqUfPrKvjTYJfr2ci7Z9e_z67OL7Orvn8uz06usUpKPWa1tQ4CVVWWuMVeybhBKKC1RLbWRDZZFo4DLIqciR441VJrrivJyehzKJTt5jr3dlD3VFYVxwM7dDr7H4dFF9O79TfBr18Z7J43JQeZTwI-XgCHebSiNrvepoq7DQHGTHNczHMw0l-z7W9YrZPs5k0A-C6ohpjRQ4yo_4ujjjPad4-DmCtxUgZsqcJ47O7uyD65t8Gf6LWUdQ3vnQ_tqsGDmZTUoo6wW83zaVv4H3ueZ3w
CitedBy_id	crossref_primary_10_3389_fimmu_2021_691480 crossref_primary_10_3389_fmicb_2017_01274 crossref_primary_10_1088_1755_1315_1305_1_012018 crossref_primary_10_1093_ecco_jcc_jjz200 crossref_primary_10_4103_ejpi_EJPI_D_24_00017 crossref_primary_10_3389_fimmu_2020_580467 crossref_primary_10_3390_ijms222111708 crossref_primary_10_1016_j_foodres_2024_114157 crossref_primary_10_1002_ange_202304815 crossref_primary_10_15406_ghoa_2019_10_00393 crossref_primary_10_31857_S0301179823020042 crossref_primary_10_1002_smll_202306169 crossref_primary_10_59058_jaimc_v20i4_59 crossref_primary_10_1007_s13206_023_00118_y crossref_primary_10_1080_08923973_2023_2298897 crossref_primary_10_1007_s10534_024_00604_2 crossref_primary_10_1111_apt_16549 crossref_primary_10_3390_jcm12247584 crossref_primary_10_3389_fmicb_2024_1393732 crossref_primary_10_1039_D0RA09117K crossref_primary_10_2147_IJGM_S324367 crossref_primary_10_1007_s11010_025_05243_w crossref_primary_10_1097_SGA_0000000000000418 crossref_primary_10_1016_j_csbj_2019_01_001 crossref_primary_10_1007_s43440_024_00616_2 crossref_primary_10_1002_mnfr_201700879 crossref_primary_10_3390_antiox10030412 crossref_primary_10_3923_ijp_2018_1160_1168 crossref_primary_10_1155_2019_3921315 crossref_primary_10_1159_000499157 crossref_primary_10_1016_j_phymed_2024_155474 crossref_primary_10_1111_apt_15485 crossref_primary_10_3390_jcm13061630 crossref_primary_10_1016_j_bj_2023_01_004 crossref_primary_10_1016_j_jhip_2023_09_004 crossref_primary_10_29001_2073_8552_2023_38_2_293_304 crossref_primary_10_11569_wcjd_v31_i17_711 crossref_primary_10_3390_diagnostics13111868 crossref_primary_10_1371_journal_pone_0264909 crossref_primary_10_7759_cureus_15016 crossref_primary_10_3748_wjg_v22_i43_9515 crossref_primary_10_1007_s00384_022_04176_w crossref_primary_10_1038_s41420_021_00444_w crossref_primary_10_3389_fphar_2022_954684 crossref_primary_10_3390_v15010173 crossref_primary_10_17816_brmma12241 crossref_primary_10_2174_0929867329666220428110427 crossref_primary_10_3390_antiox11112235 crossref_primary_10_2147_JIR_S351672 crossref_primary_10_1080_03007995_2020_1786681 crossref_primary_10_3390_cancers17050784 crossref_primary_10_3390_biom14040447 crossref_primary_10_1016_j_cca_2019_08_024 crossref_primary_10_1111_jan_16138 crossref_primary_10_1016_j_jff_2018_11_019 crossref_primary_10_1093_ibd_izab093 crossref_primary_10_4236_jbm_2024_121007 crossref_primary_10_1093_ecco_jcc_jjy100 crossref_primary_10_3389_fnut_2024_1462584 crossref_primary_10_24911_IJMDC_51_1612942108 crossref_primary_10_1016_j_bulcan_2018_02_005 crossref_primary_10_3389_fgene_2022_976578 crossref_primary_10_1002_fsn3_639 crossref_primary_10_1007_s00432_021_03909_8 crossref_primary_10_1177_00031348241256066 crossref_primary_10_1016_j_intimp_2024_112325 crossref_primary_10_1016_j_spinee_2024_03_005 crossref_primary_10_46889_JRMBR_2024_5102 crossref_primary_10_3389_fimmu_2024_1352946 crossref_primary_10_1002_imt2_136 crossref_primary_10_3389_fimmu_2024_1322054 crossref_primary_10_3390_ijms22105358 crossref_primary_10_1016_j_ijpharm_2021_120461 crossref_primary_10_23950_1812_2892_JCMK_00658 crossref_primary_10_7759_cureus_15078 crossref_primary_10_1016_j_celrep_2017_03_080 crossref_primary_10_3390_gidisord2020017 crossref_primary_10_3390_ijms232012445 crossref_primary_10_3389_phrs_2021_1603990 crossref_primary_10_1016_j_jff_2024_106167 crossref_primary_10_3389_fcimb_2024_1371543 crossref_primary_10_1080_00365521_2024_2353099 crossref_primary_10_4137_CGast_S20612 crossref_primary_10_1016_j_jep_2018_10_020 crossref_primary_10_3390_ijms20143394 crossref_primary_10_14309_ctg_0000000000000693 crossref_primary_10_1016_j_clim_2022_109100 crossref_primary_10_1021_acs_jmedchem_1c01007 crossref_primary_10_3389_fphar_2021_735194 crossref_primary_10_1016_j_biopha_2021_112148 crossref_primary_10_1097_MD_0000000000010658 crossref_primary_10_1093_rheumatology_keaa609 crossref_primary_10_1590_1414_431x20143774 crossref_primary_10_3390_ijms241210172 crossref_primary_10_1002_jpn3_12179 crossref_primary_10_1007_s40744_024_00728_4 crossref_primary_10_1093_ibd_izad247 crossref_primary_10_1242_bio_013540 crossref_primary_10_1017_S1352465819000444 crossref_primary_10_3390_diagnostics12010045 crossref_primary_10_1016_j_molimm_2017_11_020 crossref_primary_10_3389_fnut_2022_957391 crossref_primary_10_1093_advances_nmaa120 crossref_primary_10_1111_jphp_12811 crossref_primary_10_3390_ijms232415632 crossref_primary_10_3390_ijms23158751 crossref_primary_10_3390_microorganisms12101934 crossref_primary_10_1016_j_jff_2015_11_005 crossref_primary_10_1039_D2FO01512A crossref_primary_10_1002_ejp_1432 crossref_primary_10_1002_jpn3_12143 crossref_primary_10_3389_fimmu_2024_1505123 crossref_primary_10_3390_nu13072294 crossref_primary_10_3390_antiox12030769 crossref_primary_10_3390_cells13191618 crossref_primary_10_3390_nu15010031 crossref_primary_10_1016_j_biopha_2023_114950 crossref_primary_10_1002_ctm2_1345 crossref_primary_10_1109_TCBB_2022_3228617 crossref_primary_10_1093_ecco_jcc_jjad047 crossref_primary_10_1016_j_amolm_2024_100056 crossref_primary_10_1016_j_drudis_2021_02_018 crossref_primary_10_1089_jmf_2021_K_0173 crossref_primary_10_5937_Galmed2305041N crossref_primary_10_1080_19490976_2024_2416922 crossref_primary_10_1097_MD_0000000000022897 crossref_primary_10_1002_mog2_69 crossref_primary_10_3748_wjg_v28_i35_5230 crossref_primary_10_5009_gnl210488 crossref_primary_10_1093_rheumatology_keaf030 crossref_primary_10_5937_arhfarm1702124C crossref_primary_10_3233_JPD_191729 crossref_primary_10_1080_13543784_2016_1189900 crossref_primary_10_3904_kjim_2020_199 crossref_primary_10_3390_ijms21249564 crossref_primary_10_1007_s12274_023_5743_6 crossref_primary_10_5466_ijoms_21_60 crossref_primary_10_1007_s10330_018_0317_7 crossref_primary_10_7759_cureus_27656 crossref_primary_10_1080_00365521_2019_1665096 crossref_primary_10_3390_nu14122423 crossref_primary_10_1016_j_mayocp_2017_03_002 crossref_primary_10_1007_s11596_023_2741_6 crossref_primary_10_3390_ijms21217976 crossref_primary_10_3390_nu16244362 crossref_primary_10_2147_JIR_S402715 crossref_primary_10_1016_j_nut_2023_111980 crossref_primary_10_3389_fimmu_2022_912393 crossref_primary_10_1016_j_jddst_2024_106336 crossref_primary_10_1155_2017_5741948 crossref_primary_10_1038_s41430_019_0549_z crossref_primary_10_3390_pharmaceutics13040459 crossref_primary_10_1371_journal_pone_0305352 crossref_primary_10_7759_cureus_41962 crossref_primary_10_1016_j_csbj_2024_03_026 crossref_primary_10_1080_19490976_2023_2287073 crossref_primary_10_3390_ijms21165870 crossref_primary_10_1007_s40261_019_00879_1 crossref_primary_10_3389_fendo_2024_1387482 crossref_primary_10_1186_s12876_020_01447_0 crossref_primary_10_1016_j_biochi_2022_12_007 crossref_primary_10_1186_s12876_024_03480_9 crossref_primary_10_1038_s41598_020_80482_z crossref_primary_10_1111_hel_12741 crossref_primary_10_3390_biomedicines13010231 crossref_primary_10_1002_smll_201801674 crossref_primary_10_3389_fenvh_2024_1463016 crossref_primary_10_3390_nu14214622 crossref_primary_10_3390_nu16142353 crossref_primary_10_1080_08820139_2020_1787438 crossref_primary_10_1089_jmf_2017_0146 crossref_primary_10_37126_aige_v2_i3_63 crossref_primary_10_3390_microorganisms8030380 crossref_primary_10_3389_fmed_2021_716816 crossref_primary_10_1213_XAA_0000000000001804 crossref_primary_10_1080_10408398_2020_1836605 crossref_primary_10_1016_j_nut_2022_111686 crossref_primary_10_1111_idj_12542 crossref_primary_10_1007_s10787_021_00890_z crossref_primary_10_1038_s41598_019_41910_x crossref_primary_10_3748_wjg_v22_i42_9300 crossref_primary_10_3390_life14111511 crossref_primary_10_1096_fj_201900404RR crossref_primary_10_1111_php_13007 crossref_primary_10_1080_07853890_2023_2295979 crossref_primary_10_1016_j_jprot_2024_105360 crossref_primary_10_3389_fmicb_2017_00792 crossref_primary_10_15789_1563_0625_2018_5_721_730 crossref_primary_10_1097_MD_0000000000037537 crossref_primary_10_1093_ibd_izz179 crossref_primary_10_2174_1574885518666221129151025 crossref_primary_10_1128_ecosalplus_esp_0018_2022 crossref_primary_10_3389_frtra_2024_1483943 crossref_primary_10_3748_wjg_v22_i34_7718 crossref_primary_10_1080_00498254_2025_2465239 crossref_primary_10_3390_clockssleep5020021 crossref_primary_10_1007_s00384_025_04829_6 crossref_primary_10_1016_j_bj_2023_100616 crossref_primary_10_1021_acs_jmedchem_4c00222 crossref_primary_10_3389_fimmu_2017_01240 crossref_primary_10_3389_fped_2022_714054 crossref_primary_10_1007_s00535_019_01589_3 crossref_primary_10_1016_j_jff_2018_05_029 crossref_primary_10_1155_2018_9171905 crossref_primary_10_11648_j_bio_20241206_12 crossref_primary_10_1007_s10555_025_10258_2 crossref_primary_10_1016_j_jconrel_2023_08_007 crossref_primary_10_3389_fnut_2022_927363 crossref_primary_10_3390_microorganisms8101486 crossref_primary_10_14336_AD_2021_0601 crossref_primary_10_1590_s2175_97902022e201157 crossref_primary_10_3390_ijerph182312836 crossref_primary_10_1038_s41598_018_38322_8 crossref_primary_10_1016_j_phymed_2023_155178 crossref_primary_10_1007_s13770_020_00278_0 crossref_primary_10_3389_fcimb_2024_1389925 crossref_primary_10_3389_fmicb_2020_606605 crossref_primary_10_1080_14712598_2023_2279650 crossref_primary_10_7759_cureus_26121 crossref_primary_10_1002_msp2_50 crossref_primary_10_1109_TCBB_2020_2986459 crossref_primary_10_1016_j_autrev_2018_06_003 crossref_primary_10_23736_S2724_6612_24_02502_8 crossref_primary_10_3390_antiox12122071 crossref_primary_10_3390_ijms21165678 crossref_primary_10_1142_S0192415X24500745 crossref_primary_10_1016_j_autrev_2022_103260 crossref_primary_10_1155_2023_1073984 crossref_primary_10_1007_s13205_022_03349_2 crossref_primary_10_1038_s41598_019_50192_2 crossref_primary_10_1038_sj_bdj_2017_318 crossref_primary_10_1101_cshperspect_a041172 crossref_primary_10_1002_ptr_7246 crossref_primary_10_1016_j_intimp_2021_108235 crossref_primary_10_1016_j_ejmech_2020_113114 crossref_primary_10_3892_mmr_2022_12877 crossref_primary_10_1093_ilar_ilac004 crossref_primary_10_3390_ani12243456 crossref_primary_10_1142_S0192415X24500514 crossref_primary_10_3389_fmed_2022_788992 crossref_primary_10_1016_j_heliyon_2023_e22355 crossref_primary_10_1186_s12876_022_02559_5 crossref_primary_10_2174_2589977515666230502153206 crossref_primary_10_1016_j_biopha_2022_113944 crossref_primary_10_1039_D0BM01359E crossref_primary_10_1007_s12664_020_01122_y crossref_primary_10_1007_s10787_014_0207_y crossref_primary_10_1016_j_jchromb_2022_123246 crossref_primary_10_1016_j_jnutbio_2022_109238 crossref_primary_10_1002_kjm2_12397 crossref_primary_10_3389_fphar_2022_866228 crossref_primary_10_1089_ten_teb_2024_0212 crossref_primary_10_3390_molecules27196467 crossref_primary_10_1016_j_autrev_2024_103640 crossref_primary_10_1016_j_ijpharm_2018_12_074 crossref_primary_10_1159_000533525 crossref_primary_10_1186_s13287_023_03263_1 crossref_primary_10_1016_j_jbspin_2022_105367 crossref_primary_10_3389_fonc_2024_1374769 crossref_primary_10_14309_crj_0000000000000652 crossref_primary_10_3389_fnut_2022_846684 crossref_primary_10_3390_nu14163383 crossref_primary_10_4103_abr_abr_55_19 crossref_primary_10_1590_s0004_2803_24612023_155 crossref_primary_10_7759_cureus_25006 crossref_primary_10_1038_s41598_025_89252_1 crossref_primary_10_3390_nu16173031 crossref_primary_10_3390_pharmaceutics16121540 crossref_primary_10_4236_jbm_2015_38008 crossref_primary_10_3389_fimmu_2022_934695 crossref_primary_10_1111_1751_2980_13233 crossref_primary_10_1007_s10753_024_01990_y crossref_primary_10_1093_crocol_otac051 crossref_primary_10_3389_fimmu_2022_966067 crossref_primary_10_1016_j_biopha_2021_111427 crossref_primary_10_3389_fphar_2021_726707 crossref_primary_10_1186_s12903_020_1053_5 crossref_primary_10_1007_s12272_021_01318_6 crossref_primary_10_1016_j_exger_2023_112336 crossref_primary_10_5466_ijoms_18_303 crossref_primary_10_26599_FSHW_2022_9250229 crossref_primary_10_1007_s10067_022_06143_w crossref_primary_10_1007_s10096_020_04066_5 crossref_primary_10_1016_j_phymed_2023_155301 crossref_primary_10_1016_j_biopha_2023_114250 crossref_primary_10_3390_ijms24010623 crossref_primary_10_1038_s41430_023_01362_z crossref_primary_10_3390_jcm9051273 crossref_primary_10_1016_j_intimp_2024_113044 crossref_primary_10_1111_jcmm_18501 crossref_primary_10_1097_MIB_0000000000000694 crossref_primary_10_1038_s41598_024_75082_0 crossref_primary_10_1186_s12876_023_02971_5 crossref_primary_10_1038_s41423_021_00832_3 crossref_primary_10_1371_journal_pone_0183141 crossref_primary_10_3748_wjg_v30_i34_3868 crossref_primary_10_1556_650_2023_32917 crossref_primary_10_3390_jcm10245796 crossref_primary_10_1016_j_bcp_2023_115949 crossref_primary_10_3390_biom10071033 crossref_primary_10_1097_MIB_0000000000000490 crossref_primary_10_3390_nu12072032 crossref_primary_10_3390_medicina59071218 crossref_primary_10_1016_j_msard_2018_02_030 crossref_primary_10_3920_BM2020_0191 crossref_primary_10_1016_j_dld_2023_10_010 crossref_primary_10_1186_s12951_023_02176_8 crossref_primary_10_1016_j_gastre_2021_09_004 crossref_primary_10_3892_etm_2022_11488 crossref_primary_10_1080_03009742_2024_2337453 crossref_primary_10_1016_j_cellimm_2022_104532 crossref_primary_10_1016_j_trsl_2018_12_001 crossref_primary_10_1007_s11033_022_07397_y crossref_primary_10_1016_j_jep_2023_116430 crossref_primary_10_17235_reed_2019_6779_2019 crossref_primary_10_29252_koomesh_22_2_209 crossref_primary_10_1016_j_jtcme_2024_03_016 crossref_primary_10_1021_acsomega_2c01350 crossref_primary_10_3389_fimmu_2019_01177 crossref_primary_10_1186_s12906_024_04576_1 crossref_primary_10_23736_S2724_5985_21_02907_7 crossref_primary_10_3390_biomedicines10092245 crossref_primary_10_1016_j_biopha_2023_115568 crossref_primary_10_1021_acs_jmedchem_4c01838 crossref_primary_10_12968_hmed_2024_0722 crossref_primary_10_3389_fimmu_2020_00180 crossref_primary_10_1016_j_ijpharm_2019_05_025 crossref_primary_10_1039_D1FO04037E crossref_primary_10_3390_antibiotics12010154 crossref_primary_10_1016_j_heliyon_2024_e33903 crossref_primary_10_1038_s41423_021_00810_9 crossref_primary_10_5217_ir_2018_16_2_209 crossref_primary_10_1007_s00112_014_3280_9 crossref_primary_10_1016_j_phrs_2019_104603 crossref_primary_10_1021_acsabm_3c00940 crossref_primary_10_1016_j_foodres_2020_109162 crossref_primary_10_1016_j_lfs_2023_121915 crossref_primary_10_1152_ajpgi_00253_2013 crossref_primary_10_3748_wjg_v27_i36_6142 crossref_primary_10_1016_j_surge_2020_09_001 crossref_primary_10_1089_jmf_2020_0008 crossref_primary_10_1016_j_ecoenv_2021_112116 crossref_primary_10_2147_JIR_S449335 crossref_primary_10_52711_0974_360X_2024_00636 crossref_primary_10_3390_ijms24032233 crossref_primary_10_1016_j_phrs_2022_106511 crossref_primary_10_1016_j_ijbiomac_2023_123323 crossref_primary_10_1080_21655979_2021_1952368 crossref_primary_10_3389_fphar_2021_683818 crossref_primary_10_1038_ncomms10761 crossref_primary_10_3389_fneur_2024_1480681 crossref_primary_10_3389_fnagi_2023_1294879 crossref_primary_10_3390_biomedicines11072066 crossref_primary_10_3390_ijms24032238 crossref_primary_10_3390_jcm9020354 crossref_primary_10_1186_s12929_023_00983_7 crossref_primary_10_1097_MD_0000000000040401 crossref_primary_10_3390_ijms20236085 crossref_primary_10_1016_j_micpath_2019_103774 crossref_primary_10_5009_gnl230179 crossref_primary_10_1016_j_ejpb_2021_07_014 crossref_primary_10_1021_acs_jafc_4c07046 crossref_primary_10_1016_j_prenap_2024_100071 crossref_primary_10_1016_j_drudis_2016_03_007 crossref_primary_10_1186_s12974_021_02354_1 crossref_primary_10_3389_fimmu_2019_01386 crossref_primary_10_4166_kjg_2022_144 crossref_primary_10_3389_fbioe_2021_630352 crossref_primary_10_1093_crocol_otac036 crossref_primary_10_1016_j_arr_2024_102518 crossref_primary_10_3389_fendo_2024_1375896 crossref_primary_10_1002_jgh3_12836 crossref_primary_10_1089_jir_2021_0147 crossref_primary_10_1002_cmdc_202000996 crossref_primary_10_1016_j_thromres_2023_11_005 crossref_primary_10_1177_1755738019856030 crossref_primary_10_36290_ped_2018_038 crossref_primary_10_1016_j_gastrohep_2020_10_008 crossref_primary_10_1007_s12664_019_00976_1 crossref_primary_10_3390_nu16244305 crossref_primary_10_3748_wjg_v22_i3_895 crossref_primary_10_1016_j_jdrv_2024_07_001 crossref_primary_10_3390_ijms24010802 crossref_primary_10_1007_s00011_020_01339_9 crossref_primary_10_1016_j_jnutbio_2022_109183 crossref_primary_10_1007_s12325_021_01651_8 crossref_primary_10_1016_j_jcmgh_2016_10_004 crossref_primary_10_15252_embj_201592649 crossref_primary_10_1038_s42003_025_07917_z crossref_primary_10_1097_MD_0000000000028515 crossref_primary_10_3390_microorganisms8081165 crossref_primary_10_2174_1381612826666200211122633 crossref_primary_10_3389_fcell_2025_1563427 crossref_primary_10_1016_j_intimp_2016_07_034 crossref_primary_10_1007_s13167_024_00384_2 crossref_primary_10_3390_ijms25084241 crossref_primary_10_1016_j_jconrel_2024_11_064 crossref_primary_10_3390_molecules28217412 crossref_primary_10_1155_2021_8816041 crossref_primary_10_1002_psp4_12840 crossref_primary_10_30699_jambs_28_130_237 crossref_primary_10_3390_ijms25010202 crossref_primary_10_1016_j_medmic_2020_100026 crossref_primary_10_1093_nutrit_nuae107 crossref_primary_10_1186_s13020_019_0245_x crossref_primary_10_1111_jgh_13254 crossref_primary_10_3390_jcm9123941 crossref_primary_10_3390_biomedicines10082025 crossref_primary_10_3390_ijms222011155 crossref_primary_10_3389_fimmu_2024_1439371 crossref_primary_10_1080_27706710_2023_2181101 crossref_primary_10_1007_s12664_022_01257_0 crossref_primary_10_1155_2019_9406146 crossref_primary_10_1080_17425247_2023_2237408 crossref_primary_10_1093_ibd_izae064 crossref_primary_10_3390_ijms25169026 crossref_primary_10_3390_nu14061175 crossref_primary_10_1007_s00232_023_00277_x crossref_primary_10_3748_wjg_v30_i1_17 crossref_primary_10_1371_journal_pone_0170792 crossref_primary_10_7759_cureus_42020 crossref_primary_10_1053_j_jfas_2014_06_024 crossref_primary_10_3389_fmed_2021_770491 crossref_primary_10_1016_j_ctim_2019_01_015 crossref_primary_10_3389_fimmu_2022_969399 crossref_primary_10_3390_diagnostics14141530 crossref_primary_10_1016_j_inpm_2024_100524 crossref_primary_10_1038_s41598_022_13629_9 crossref_primary_10_3389_fcell_2023_1213383 crossref_primary_10_1007_s12098_023_04671_0 crossref_primary_10_1016_j_ajpath_2023_02_004 crossref_primary_10_3389_fimmu_2021_694217 crossref_primary_10_3390_nu14173543 crossref_primary_10_1016_j_jad_2019_01_014 crossref_primary_10_1515_pteridines_2018_0020 crossref_primary_10_71079_ASIDE_GI_03132515 crossref_primary_10_1080_08998280_2024_2303402 crossref_primary_10_1038_bdjteam_2017_83 crossref_primary_10_3390_genes12101465 crossref_primary_10_1016_j_ejmg_2017_08_016 crossref_primary_10_3389_fimmu_2023_1239732 crossref_primary_10_1016_j_intimp_2020_107304 crossref_primary_10_3390_ijms24065517 crossref_primary_10_1016_j_pscia_2023_100014 crossref_primary_10_1186_s12967_021_02732_6 crossref_primary_10_1016_j_molimm_2018_09_004 crossref_primary_10_1016_j_reth_2019_12_005 crossref_primary_10_1016_j_jep_2023_117578 crossref_primary_10_1016_j_jhazmat_2021_126676 crossref_primary_10_1038_s41598_021_00088_x crossref_primary_10_1016_j_cjac_2023_100354 crossref_primary_10_1016_j_jaut_2020_102453 crossref_primary_10_3390_ijms23158137 crossref_primary_10_7783_KJMCS_2024_32_6_393 crossref_primary_10_3389_fimmu_2023_1238457 crossref_primary_10_1093_toxsci_kfae004 crossref_primary_10_1007_s10620_024_08380_2 crossref_primary_10_1002_advs_202304044 crossref_primary_10_1002_jpn3_12329 crossref_primary_10_1097_ICU_0000000000000310 crossref_primary_10_1002_jcla_24455 crossref_primary_10_1155_2022_1283383 crossref_primary_10_1177_17562848231158235 crossref_primary_10_3390_antiox12040850 crossref_primary_10_3390_microorganisms11071858 crossref_primary_10_1007_s10151_020_02349_9 crossref_primary_10_1007_s11938_017_0129_z crossref_primary_10_3389_fimmu_2021_773070 crossref_primary_10_3109_21691401_2014_975239 crossref_primary_10_3389_fphar_2024_1491763 crossref_primary_10_3389_fimmu_2023_1215329 crossref_primary_10_11569_wcjd_v29_i24_1402 crossref_primary_10_3390_biomedicines11112985 crossref_primary_10_1002_btm2_10446 crossref_primary_10_1515_sosi_2019_0001 crossref_primary_10_3390_antiox12081570 crossref_primary_10_1016_j_scr_2019_101383 crossref_primary_10_2174_1381612825666191216154224 crossref_primary_10_3748_wjg_v31_i2_100589 crossref_primary_10_1016_j_biomaterials_2022_121707 crossref_primary_10_3390_cells12172184 crossref_primary_10_1016_j_dld_2024_05_021 crossref_primary_10_1016_j_lfs_2024_122700 crossref_primary_10_1007_s11033_021_06357_2 crossref_primary_10_3390_molecules26195812 crossref_primary_10_1155_2023_7915367 crossref_primary_10_3390_ph14080708 crossref_primary_10_1155_2022_3762591 crossref_primary_10_3390_antiox7030036 crossref_primary_10_3389_fimmu_2024_1405790 crossref_primary_10_7759_cureus_44895 crossref_primary_10_1097_MPG_0000000000001182 crossref_primary_10_1556_650_2021_32070 crossref_primary_10_1007_s10620_021_06947_x crossref_primary_10_1097_MEG_0000000000001816 crossref_primary_10_1038_s41598_017_11734_8 crossref_primary_10_1159_000507931 crossref_primary_10_2174_0113816128295753240129074035 crossref_primary_10_3390_pathogens11010084 crossref_primary_10_1111_apt_16365 crossref_primary_10_3748_wjg_v27_i19_2270 crossref_primary_10_1002_fsn3_3043 crossref_primary_10_1016_j_biopha_2023_115758 crossref_primary_10_1002_adfm_201909556 crossref_primary_10_1007_s12272_020_01296_1 crossref_primary_10_1093_ije_dyv088 crossref_primary_10_1007_s12272_021_01327_5 crossref_primary_10_1093_nutrit_nuab028 crossref_primary_10_1016_j_clnu_2025_02_019 crossref_primary_10_1016_j_ecoenv_2021_112161 crossref_primary_10_1590_s0004_2803_202203000_65 crossref_primary_10_5009_gnl18072 crossref_primary_10_1016_j_intimp_2024_112404 crossref_primary_10_1016_j_autrev_2024_103578 crossref_primary_10_1093_bioadv_vbab017 crossref_primary_10_1111_1747_0080_12715 crossref_primary_10_15171_mejdd_2019_149 crossref_primary_10_5144_0256_4947_2015_19 crossref_primary_10_3390_ijms23126626 crossref_primary_10_22627_2072_8107_2021_20_3_67_72 crossref_primary_10_1016_j_dld_2017_08_003 crossref_primary_10_3390_jcm13010140 crossref_primary_10_1111_jcpt_13662 crossref_primary_10_1002_ame2_12255 crossref_primary_10_3390_ijms232314841 crossref_primary_10_3389_fimmu_2023_1125224 crossref_primary_10_3390_ijms22168855 crossref_primary_10_1016_j_revmed_2019_07_016 crossref_primary_10_1159_000367821 crossref_primary_10_1080_08941939_2018_1469697 crossref_primary_10_7759_cureus_28697 crossref_primary_10_1053_j_gastro_2023_02_046 crossref_primary_10_1080_19490976_2023_2297831 crossref_primary_10_1016_j_intimp_2023_111042 crossref_primary_10_3390_jcm11185267 crossref_primary_10_12968_bjon_2021_30_14_840 crossref_primary_10_3390_ijms24119730 crossref_primary_10_3748_wjg_v26_i32_4866 crossref_primary_10_1159_000521259 crossref_primary_10_3390_nu16111780 crossref_primary_10_7759_cureus_51004 crossref_primary_10_1002_jsfa_14123 crossref_primary_10_1080_1744666X_2018_1532291 crossref_primary_10_1016_j_synres_2017_03_001 crossref_primary_10_1093_pcmedi_pbad031 crossref_primary_10_3390_ijms23169127 crossref_primary_10_3390_ijms25158534 crossref_primary_10_1016_j_imlet_2022_07_006 crossref_primary_10_1155_2017_8547257 crossref_primary_10_1371_journal_pone_0252805 crossref_primary_10_1016_j_autrev_2020_102584 crossref_primary_10_1016_j_phrs_2022_106056 crossref_primary_10_1080_15548627_2015_1017187 crossref_primary_10_1016_j_ijbiomac_2024_136392 crossref_primary_10_1093_ibd_izad161 crossref_primary_10_1111_jcmm_18175 crossref_primary_10_1016_j_nutres_2023_10_001 crossref_primary_10_1159_000500546 crossref_primary_10_1016_j_jcmgh_2018_10_012 crossref_primary_10_3390_ijms25063278 crossref_primary_10_1002_ctd2_249 crossref_primary_10_1016_j_clinre_2019_05_006 crossref_primary_10_1097_MCO_0000000000000829 crossref_primary_10_3389_fmed_2022_1058373 crossref_primary_10_1016_j_jss_2024_11_041 crossref_primary_10_1038_s41598_020_69567_x crossref_primary_10_1093_ecco_jcc_jjae050 crossref_primary_10_1007_s00705_017_3569_9 crossref_primary_10_3389_fimmu_2020_00852 crossref_primary_10_1556_650_2024_33053 crossref_primary_10_1016_j_jare_2024_03_026 crossref_primary_10_1002_eji_202048777 crossref_primary_10_3389_fimmu_2023_1168188 crossref_primary_10_1016_j_jff_2023_105912 crossref_primary_10_1038_s41537_022_00244_w crossref_primary_10_1590_fst_65721 crossref_primary_10_1016_j_gastre_2020_03_001 crossref_primary_10_1007_s10044_023_01206_3 crossref_primary_10_3389_fmed_2024_1307394 crossref_primary_10_3389_fmicb_2022_916824 crossref_primary_10_3389_fimmu_2020_00687 crossref_primary_10_1016_j_jgg_2019_03_007 crossref_primary_10_3390_biology13110916 crossref_primary_10_2147_CEG_S288688 crossref_primary_10_5217_ir_2021_00022 crossref_primary_10_1038_s41420_023_01455_5 crossref_primary_10_1111_hdi_13106 crossref_primary_10_3390_ijms222313038 crossref_primary_10_3390_md23010047 crossref_primary_10_3389_fimmu_2022_1067950 crossref_primary_10_3390_nu13030773 crossref_primary_10_3390_ijms25031858 crossref_primary_10_1093_gastro_goad004 crossref_primary_10_1002_anie_202304815 crossref_primary_10_1007_s00394_021_02489_0 crossref_primary_10_3390_ijms19072025 crossref_primary_10_2174_1381612825666190405141410 crossref_primary_10_3389_fimmu_2021_761981 crossref_primary_10_1016_j_arr_2024_102286 crossref_primary_10_3748_wjg_v27_i12_1149 crossref_primary_10_1038_srep45012 crossref_primary_10_3748_wjg_v29_i30_4604 crossref_primary_10_1007_s00204_020_02817_z crossref_primary_10_1007_s13679_019_00332_6 crossref_primary_10_3390_ijms241612767 crossref_primary_10_3390_ijms252111499 crossref_primary_10_1093_ibd_izab183 crossref_primary_10_1093_ibd_izab180 crossref_primary_10_1111_apt_16656 crossref_primary_10_3389_fnut_2022_1088693 crossref_primary_10_1016_j_cbi_2016_04_033 crossref_primary_10_1186_s12950_024_00393_y crossref_primary_10_1155_2016_5359768 crossref_primary_10_1007_s12011_024_04074_y crossref_primary_10_1111_apa_17574 crossref_primary_10_1097_DCR_0000000000002944 crossref_primary_10_1080_17425255_2020_1701653 crossref_primary_10_1016_j_isci_2023_108084 crossref_primary_10_1007_s00384_023_04575_7 crossref_primary_10_14309_ctg_0000000000000549 crossref_primary_10_3390_biomedicines12051000 crossref_primary_10_3748_wjg_v26_i24_3365 crossref_primary_10_1016_j_cca_2022_02_013 crossref_primary_10_1111_bcpt_13624 crossref_primary_10_3390_ijms25136935 crossref_primary_10_1016_j_cyto_2023_156292 crossref_primary_10_1155_2021_5583994 crossref_primary_10_2147_JIR_S478880 crossref_primary_10_1007_s11655_022_3543_6 crossref_primary_10_5937_arhfarm1702112N crossref_primary_10_1007_s00203_023_03570_4 crossref_primary_10_3390_nu16111562 crossref_primary_10_1093_ecco_jcc_jjad164 crossref_primary_10_3390_jcm13247710 crossref_primary_10_3390_jcm10112466 crossref_primary_10_1016_j_bbrc_2018_01_053 crossref_primary_10_1007_s00011_023_01835_8 crossref_primary_10_1038_s41598_025_85249_y crossref_primary_10_1186_s12985_022_01845_8 crossref_primary_10_1053_j_sempedsurg_2017_10_002 crossref_primary_10_12677_ACM_2022_12121582 crossref_primary_10_3390_jcm14061793 crossref_primary_10_1186_s12944_024_02203_z crossref_primary_10_3390_ijms24119581 crossref_primary_10_1016_j_nutres_2017_10_005 crossref_primary_10_3389_fimmu_2024_1434369 crossref_primary_10_4049_jimmunol_1800139 crossref_primary_10_1016_j_med_2020_05_010 crossref_primary_10_3390_jcm10225311 crossref_primary_10_1007_s10787_022_01085_w crossref_primary_10_1016_j_carbpol_2024_122832 crossref_primary_10_3390_pharmaceutics13040576 crossref_primary_10_3389_fimmu_2015_00551 crossref_primary_10_3389_fimmu_2019_01438 crossref_primary_10_3389_fmed_2024_1399658 crossref_primary_10_3389_fphar_2023_1045997 crossref_primary_10_7759_cureus_14216 crossref_primary_10_1002_mnfr_202000129 crossref_primary_10_1093_mrcr_rxad031 crossref_primary_10_3390_ijms23094529 crossref_primary_10_3390_biom9090398 crossref_primary_10_3390_molecules26010042 crossref_primary_10_1080_08820139_2024_2343889 crossref_primary_10_1152_ajpgi_00012_2023 crossref_primary_10_1177_1756283X15607414 crossref_primary_10_1111_ans_18827 crossref_primary_10_3390_foods12101928 crossref_primary_10_3233_MNM_190367 crossref_primary_10_1089_jmf_2021_K_0086 crossref_primary_10_1111_jvim_16141 crossref_primary_10_1371_journal_pone_0190074 crossref_primary_10_3389_fimmu_2019_01464 crossref_primary_10_1016_j_cellimm_2017_11_004 crossref_primary_10_1590_s0004_2803_246102023_95 crossref_primary_10_3347_kjp_2022_60_5_309 crossref_primary_10_3390_ijms25189886 crossref_primary_10_1016_j_carbpol_2020_117142 crossref_primary_10_2174_0122127968320045240927120032 crossref_primary_10_1590_s0004_2803_201800000_34 crossref_primary_10_1093_ibd_izab136 crossref_primary_10_1016_j_autrev_2024_103720 crossref_primary_10_3748_wjg_v26_i30_4378 crossref_primary_10_1186_s13098_023_01252_1 crossref_primary_10_3390_microorganisms10091833 crossref_primary_10_1007_s00384_023_04437_2 crossref_primary_10_1177_1756283X15576462 crossref_primary_10_1016_j_gastrohep_2020_03_007 crossref_primary_10_1016_j_phrs_2020_104921 crossref_primary_10_1016_j_jconrel_2017_06_013 crossref_primary_10_1177_17562848241290636 crossref_primary_10_3390_jcm11154374 crossref_primary_10_2174_0127724328245156231008154045 crossref_primary_10_2147_JIR_S320449 crossref_primary_10_7759_cureus_16859 crossref_primary_10_1007_s10238_024_01496_9 crossref_primary_10_1016_j_autrev_2022_103136 crossref_primary_10_1016_j_jnutbio_2014_12_001 crossref_primary_10_15171_ijer_2019_25 crossref_primary_10_1016_j_wneu_2025_123718 crossref_primary_10_1177_17562848221144349 crossref_primary_10_1021_acsptsci_4c00102 crossref_primary_10_1002_eji_201344403 crossref_primary_10_3390_nu14214562 crossref_primary_10_1371_journal_pone_0280850 crossref_primary_10_1007_s11136_019_02170_4 crossref_primary_10_3389_fnut_2023_1209613 crossref_primary_10_3390_cells13050373 crossref_primary_10_1016_j_molmed_2023_01_001 crossref_primary_10_3389_fmed_2022_1023896 crossref_primary_10_3389_fphar_2020_00153 crossref_primary_10_1159_000509110 crossref_primary_10_3389_fgene_2024_1383162 crossref_primary_10_1080_21691401_2016_1198363 crossref_primary_10_3389_fphar_2025_1543194 crossref_primary_10_1016_j_jare_2024_05_002 crossref_primary_10_3390_nu13030938 crossref_primary_10_1007_s12275_021_0305_7 crossref_primary_10_1016_j_intimp_2024_112271 crossref_primary_10_1128_AEM_02147_18 crossref_primary_10_1155_2022_8266793 crossref_primary_10_1007_s00394_020_02250_z crossref_primary_10_1016_j_nantod_2023_101876 crossref_primary_10_3390_foods12040897 crossref_primary_10_1016_j_jff_2023_105499 crossref_primary_10_2174_1573413715666190411141126 crossref_primary_10_31883_pjfns_2019_0013 crossref_primary_10_1016_j_celrep_2019_02_019 crossref_primary_10_1136_annrheumdis_2017_211555 crossref_primary_10_1002_bip_70012 crossref_primary_10_1016_j_intimp_2024_113358 crossref_primary_10_3390_pharmaceutics15112600 crossref_primary_10_3390_ph15121515 crossref_primary_10_3390_biomedicines12020345 crossref_primary_10_18632_aging_205728 crossref_primary_10_1021_acssynbio_4c00036 crossref_primary_10_17116_patol201678119_24 crossref_primary_10_3390_pharmaceutics13101644 crossref_primary_10_1016_j_crfs_2024_100955 crossref_primary_10_3390_medicina60071106 crossref_primary_10_3390_ijms22157931 crossref_primary_10_1152_ajpgi_00311_2015 crossref_primary_10_1111_bph_16059 crossref_primary_10_7759_cureus_48451 crossref_primary_10_3389_fmed_2022_1020126 crossref_primary_10_3390_biom14050577 crossref_primary_10_1016_j_xcrm_2023_101038 crossref_primary_10_1186_s13104_024_06999_y crossref_primary_10_3389_fphar_2023_1217306 crossref_primary_10_3389_fmed_2024_1485087 crossref_primary_10_3748_wjg_v26_i48_7593 crossref_primary_10_1016_j_intimp_2020_107183 crossref_primary_10_3389_fnins_2024_1458918 crossref_primary_10_5217_ir_2020_00079 crossref_primary_10_3389_fmicb_2020_00497 crossref_primary_10_3390_nu12082367 crossref_primary_10_3390_nu15132886 crossref_primary_10_1016_j_suc_2024_09_004 crossref_primary_10_1155_2016_4281865 crossref_primary_10_18632_aging_205734 crossref_primary_10_1016_j_jnutbio_2022_109101 crossref_primary_10_1124_dmd_115_065714 crossref_primary_10_1007_s11938_019_00255_0 crossref_primary_10_7759_cureus_15568 crossref_primary_10_5604_01_3001_0014_6581 crossref_primary_10_1016_j_pdpdt_2024_104220 crossref_primary_10_1007_s10620_018_5309_8 crossref_primary_10_3390_biom12081163 crossref_primary_10_31146_1682_8658_ecg_202_6_76_82 crossref_primary_10_5217_ir_2018_16_3_374 crossref_primary_10_1155_2022_7280977 crossref_primary_10_1186_s13036_021_00259_4 crossref_primary_10_2147_IJN_S355366 crossref_primary_10_1007_s10620_015_3997_x crossref_primary_10_12998_wjcc_v7_i15_1908 crossref_primary_10_1002_jcla_24130 crossref_primary_10_1016_j_cgh_2016_05_035 crossref_primary_10_3390_md17110622 crossref_primary_10_1016_j_clinbiomech_2021_105445 crossref_primary_10_1002_smll_202003158 crossref_primary_10_1016_j_chmed_2023_03_003 crossref_primary_10_1093_jscr_rjac586 crossref_primary_10_1186_s13020_021_00553_9 crossref_primary_10_1016_j_bbagen_2019_07_001 crossref_primary_10_1016_j_jconrel_2020_01_047 crossref_primary_10_1186_s12876_024_03571_7 crossref_primary_10_1186_s40001_024_01932_2 crossref_primary_10_3390_biomedicines10040919 crossref_primary_10_1016_j_phrs_2018_11_036 crossref_primary_10_1136_bmjopen_2018_026315 crossref_primary_10_1093_crocol_otab079 crossref_primary_10_1155_2020_4253174 crossref_primary_10_3389_fimmu_2023_1327879 crossref_primary_10_36106_ijsr_5410073 crossref_primary_10_1007_s40846_019_00494_7 crossref_primary_10_1007_s10620_015_3646_4 crossref_primary_10_1007_s11845_022_03097_5 crossref_primary_10_3389_fmicb_2024_1463005 crossref_primary_10_3390_biomedicines10092130 crossref_primary_10_3390_cells11244103 crossref_primary_10_1039_D1FO00659B crossref_primary_10_1186_s40942_019_0168_9 crossref_primary_10_3390_nu9101112 crossref_primary_10_3390_cells10123589 crossref_primary_10_3389_fimmu_2022_1028953 crossref_primary_10_1016_j_ijbiomac_2024_133794 crossref_primary_10_1080_07391102_2022_2050948 crossref_primary_10_1016_j_jff_2022_105181 crossref_primary_10_3390_biomedicines8080268 crossref_primary_10_1002_admt_202100903 crossref_primary_10_1007_s40200_021_00913_0 crossref_primary_10_3892_etm_2017_4577 crossref_primary_10_3390_nu16223956 crossref_primary_10_1155_2023_8815971 crossref_primary_10_1016_j_hermed_2017_05_002 crossref_primary_10_1159_000494026 crossref_primary_10_3389_fnut_2022_905162 crossref_primary_10_7759_cureus_14964 crossref_primary_10_1016_j_smim_2017_09_007 crossref_primary_10_3748_wjg_v23_i1_76 crossref_primary_10_1093_rheumatology_keaa064 crossref_primary_10_3390_polym15061414 crossref_primary_10_1159_000507851 crossref_primary_10_3390_ijms22010362 crossref_primary_10_1080_08820139_2020_1840582 crossref_primary_10_1080_20905068_2019_1592938 crossref_primary_10_3390_ijms25010165 crossref_primary_10_1097_MD_0000000000019729 crossref_primary_10_1055_a_1354_0630 crossref_primary_10_1080_08923973_2020_1790595 crossref_primary_10_1093_ibd_izz217 crossref_primary_10_1186_s12906_021_03337_8 crossref_primary_10_3389_fmed_2024_1449037 crossref_primary_10_3390_molecules28114392 crossref_primary_10_1007_s11684_023_0990_1 crossref_primary_10_1097_MIB_0000000000000117 crossref_primary_10_3748_wjg_v25_i33_4796 crossref_primary_10_1038_s41598_024_60959_x crossref_primary_10_3389_fnut_2022_988758 crossref_primary_10_4068_cmj_2023_59_1_13 crossref_primary_10_1039_D4FO00194J crossref_primary_10_3389_fphar_2019_00825 crossref_primary_10_1016_j_ejphar_2023_175994 crossref_primary_10_1016_j_heliyon_2022_e11007 crossref_primary_10_3390_nu15081991 crossref_primary_10_3390_biomedicines10102439 crossref_primary_10_3390_nu16121826 crossref_primary_10_1007_s12325_021_01661_6 crossref_primary_10_3390_children10101677 crossref_primary_10_1556_030_2021_01498 crossref_primary_10_1002_14651858_CD006790_pub3 crossref_primary_10_3390_ijms25115793 crossref_primary_10_1111_nyas_13426 crossref_primary_10_3390_pharmaceutics14112449 crossref_primary_10_1016_j_retram_2019_01_002 crossref_primary_10_1093_jcag_gwae027 crossref_primary_10_1007_s00436_024_08450_4 crossref_primary_10_1021_acs_jafc_3c08811 crossref_primary_10_1039_D3FO01226C crossref_primary_10_1038_s41598_023_46184_y crossref_primary_10_1186_s12950_021_00279_3 crossref_primary_10_4132_jptm_2022_11_02 crossref_primary_10_1038_s41598_019_55378_2 crossref_primary_10_1016_j_biopha_2022_114081 crossref_primary_10_1186_s43556_023_00135_1 crossref_primary_10_18632_oncotarget_22675 crossref_primary_10_1016_j_micpath_2022_105821 crossref_primary_10_1186_s12863_024_01274_2 crossref_primary_10_1016_j_fochx_2021_100190 crossref_primary_10_1039_D3NR05495K crossref_primary_10_1177_13558196241276979 crossref_primary_10_5812_jjcdc_42794 crossref_primary_10_3389_fgene_2024_1376123 crossref_primary_10_1007_s10620_020_06204_7 crossref_primary_10_1177_1756284819881304 crossref_primary_10_1007_s00441_023_03786_2 crossref_primary_10_1002_ptr_7874 crossref_primary_10_1093_crocol_otab065 crossref_primary_10_1177_17562848211004469 crossref_primary_10_1111_apt_18270 crossref_primary_10_1016_j_gene_2024_149125 crossref_primary_10_1097_MOG_0000000000000317 crossref_primary_10_1016_j_foodres_2021_110568 crossref_primary_10_7759_cureus_33266 crossref_primary_10_3390_nu13061956 crossref_primary_10_2147_CEG_S267172 crossref_primary_10_1097_CM9_0000000000000364 crossref_primary_10_3748_wjg_v29_i2_310 crossref_primary_10_1080_00365521_2020_1854847 crossref_primary_10_3389_fphys_2020_00589 crossref_primary_10_1007_s00535_022_01902_7 crossref_primary_10_1016_j_jfma_2024_06_004 crossref_primary_10_1177_2040622315586970 crossref_primary_10_1016_j_jddst_2023_104723 crossref_primary_10_3389_fimmu_2023_1221068 crossref_primary_10_26599_FSHW_2023_9250019 crossref_primary_10_1097_MEG_0000000000002614 crossref_primary_10_3748_wjg_v22_i28_6434 crossref_primary_10_1515_jbcpp_2019_0166 crossref_primary_10_1093_ibd_izae194 crossref_primary_10_1111_ejn_16442 crossref_primary_10_1080_87559129_2023_2273929 crossref_primary_10_1016_j_addr_2023_115119 crossref_primary_10_2174_1574893618666230316113621 crossref_primary_10_3892_ol_2024_14390 crossref_primary_10_1016_j_jaut_2023_103062 crossref_primary_10_3892_ijmm_2024_5370 crossref_primary_10_3390_nu11081743 crossref_primary_10_1016_j_pharep_2016_04_008 crossref_primary_10_1016_j_pharep_2016_04_007 crossref_primary_10_1007_s40257_023_00765_9 crossref_primary_10_7759_cureus_10544 crossref_primary_10_3390_antiox13070795 crossref_primary_10_1177_1756283X16644242 crossref_primary_10_1021_acsnano_3c11089 crossref_primary_10_1016_j_cbi_2021_109512 crossref_primary_10_1016_j_jnutbio_2018_07_010 crossref_primary_10_1248_bpb_b23_00406 crossref_primary_10_1016_j_lfs_2024_122638 crossref_primary_10_1016_j_jtauto_2025_100271 crossref_primary_10_1111_cge_14001 crossref_primary_10_1007_s13205_021_02755_2 crossref_primary_10_1136_bmjopen_2024_094280 crossref_primary_10_3390_ijms21114046 crossref_primary_10_1002_iid3_1144 crossref_primary_10_3892_etm_2022_11552 crossref_primary_10_1073_pnas_1720696115 crossref_primary_10_1155_2021_3334994 crossref_primary_10_1007_s40261_024_01364_0 crossref_primary_10_3390_gidisord1020024 crossref_primary_10_1038_s41467_024_53144_1 crossref_primary_10_1016_j_dld_2023_04_022 crossref_primary_10_3390_ijms222011255 crossref_primary_10_1038_s41401_024_01399_1 crossref_primary_10_1007_s00011_023_01840_x crossref_primary_10_1016_j_ejphar_2018_03_027 crossref_primary_10_1007_s00392_024_02476_5 crossref_primary_10_1007_s00394_023_03214_9 crossref_primary_10_3892_etm_2017_5251 crossref_primary_10_1002_ptr_7819 crossref_primary_10_1017_gmb_2023_17 crossref_primary_10_1016_j_eclinm_2022_101300 crossref_primary_10_1186_s13643_022_02064_6 crossref_primary_10_1093_ecco_jcc_jjz156 crossref_primary_10_1016_j_jep_2022_116095 crossref_primary_10_3389_fimmu_2022_872760 crossref_primary_10_1080_08820139_2025_2468959 crossref_primary_10_3390_ijms232314890 crossref_primary_10_1080_21645515_2023_2259418 crossref_primary_10_3390_nu13020323 crossref_primary_10_1002_JPER_22_0205 crossref_primary_10_1111_jam_15406 crossref_primary_10_1097_MEG_0000000000000877 crossref_primary_10_1080_01635581_2023_2223789 crossref_primary_10_1186_s12876_024_03128_8 crossref_primary_10_2147_JIR_S344031 crossref_primary_10_3389_fcimb_2022_940576 crossref_primary_10_1021_acs_jafc_2c05177 crossref_primary_10_1097_MD_0000000000019768 crossref_primary_10_1093_ibd_izy319 crossref_primary_10_3390_gidisord5020015 crossref_primary_10_1111_fcp_12894 crossref_primary_10_1111_cen_13332 crossref_primary_10_3390_biomedicines10061242 crossref_primary_10_5812_aapm_113027 crossref_primary_10_1016_j_pharmthera_2020_107687 crossref_primary_10_1007_s10787_022_01044_5 crossref_primary_10_1016_j_jconrel_2022_03_037 crossref_primary_10_4264_numa_77_3_197 crossref_primary_10_3389_fbioe_2021_675194 crossref_primary_10_3390_ijms20153816 crossref_primary_10_1016_j_intimp_2023_110434 crossref_primary_10_1039_D0FO00713G crossref_primary_10_1093_jcag_gwac009 crossref_primary_10_1021_acs_jafc_9b05829 crossref_primary_10_3390_jcm8081191 crossref_primary_10_3390_biology13090674 crossref_primary_10_3164_jcbn_15_56 crossref_primary_10_1016_j_jnutbio_2020_108438 crossref_primary_10_3389_fnut_2025_1494351 crossref_primary_10_2174_0113894501255960231101105113 crossref_primary_10_1007_s10620_024_08283_2 crossref_primary_10_3892_mmr_2024_13281 crossref_primary_10_1007_s00210_015_1110_9 crossref_primary_10_1007_s00431_021_03987_3 crossref_primary_10_1016_j_actbio_2024_06_021 crossref_primary_10_1016_j_jep_2024_117990 crossref_primary_10_1080_19490976_2022_2154092 crossref_primary_10_1038_gene_2015_52 crossref_primary_10_1007_s10787_021_00831_w crossref_primary_10_3389_fmicb_2021_623920 crossref_primary_10_1007_s00108_018_0473_7 crossref_primary_10_1136_annrheumdis_2018_213023 crossref_primary_10_1016_j_ijpharm_2021_120717 crossref_primary_10_58600_eurjther1883 crossref_primary_10_4014_jmb_2404_04020 crossref_primary_10_3748_wjg_v20_i36_12713 crossref_primary_10_1080_19490976_2023_2172671 crossref_primary_10_1007_s12041_023_01433_x crossref_primary_10_1080_17474124_2019_1685872 crossref_primary_10_2147_IJN_S264513 crossref_primary_10_3748_wjg_v29_i3_508 crossref_primary_10_3389_fphar_2021_632569 crossref_primary_10_7759_cureus_17187 crossref_primary_10_3390_ijerph17249365 crossref_primary_10_1007_s10068_023_01378_y crossref_primary_10_3390_ijms22020595 crossref_primary_10_17352_2455_2283_000066 crossref_primary_10_1007_s11101_023_09866_z crossref_primary_10_3177_jnsv_65_31 crossref_primary_10_3748_wjg_v28_i16_1705 crossref_primary_10_1111_1750_3841_16723 crossref_primary_10_1093_ecco_jcc_jjad204 crossref_primary_10_2139_ssrn_4016460 crossref_primary_10_1073_pnas_2024853118
ContentType	Journal Article
Copyright	2014 Baishideng Publishing Group Co., Limited. All rights reserved. 2014
Copyright_xml	– notice: 2014 Baishideng Publishing Group Co., Limited. All rights reserved. 2014
DBID	2RA 92L CQIGP W91 ~WA AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM
DOI	10.3748/wjg.v20.i1.91
DatabaseName	维普_期刊中文科技期刊数据库-CALIS站点中文科技期刊数据库-7.0平台中文科技期刊数据库-医药卫生中文科技期刊数据库- 镜像站点 CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic PubMed Central (Full Participant titles)
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic MEDLINE
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database
DeliveryMethod	fulltext_linktorsrc
DocumentTitleAlternate	Inflammatory bowel disease:Pathogenesis
EISSN	2219-2840
EndPage	99
ExternalDocumentID	PMC3886036 24415861 10_3748_wjg_v20_i1_91 90888889504849524849484949
Genre	Research Support, Non-U.S. Gov't Journal Article Review
GroupedDBID	--- 123 29R 2B. 2C~ 2RA 2WC 36B 53G 5VR 8WL 92F 92I 92L 93N 93R AAKDD ACGFO AENEX AFUIB ALMA_UNASSIGNED_HOLDINGS CCEZO CHBEP CIEJG CQIGP CS3 CW9 DIK DU5 E3Z EBS EJD EMB F5P FA0 FRP GX1 HYE M~E OK1 P2P RNS RPM SV3 TCJ TGQ TR2 W91 WFFXF XSB ~WA AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM
ID	FETCH-LOGICAL-c431t-d59fe0ac94b65a643dfa0b0b9eed3583fab7f401376e76a1ad0c515ce6b023a3
ISSN	1007-9327 2219-2840
IngestDate	Thu Aug 21 14:03:20 EDT 2025 Fri Jul 11 00:47:45 EDT 2025 Thu Apr 03 06:59:52 EDT 2025 Tue Jul 01 01:53:29 EDT 2025 Thu Apr 24 23:02:53 EDT 2025 Wed Feb 14 10:28:36 EST 2024
IsDoiOpenAccess	false
IsOpenAccess	true
IsPeerReviewed	false
IsScholarly	true
Issue	1
Keywords	Inflammatory bowel disease Microbial factors Pathogenesis Genetics Immune responses Crohn’s disease Ulcerative colitis
Language	English
LinkModel	OpenURL
MergedId	FETCHMERGED-LOGICAL-c431t-d59fe0ac94b65a643dfa0b0b9eed3583fab7f401376e76a1ad0c515ce6b023a3
Notes	Yi-Zhen Zhang;Yong-Yu Li;Department of Pathophysiology,Tongji University School of Medicine ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 Correspondence to: Yong-Yu Li, MD, Department of Pathophysiology, Tongji University School of Medicine, Siping Road 1239, Shanghai 200092, China. liyongyu@tongji.edu.cn Author contributions: Zhang YZ and Li YY have substantial contributions to conception and design, and acquisition of data; Zhang YZ drafted the article; Li YY revised the manuscript critically for important intellectual content; Zhang YZ and Li YY worked together for the final approval of the version to be published. Telephone: +86-21-65981021 Fax: +86-21-65987071
OpenAccessLink	https://www.wjgnet.com/1007-9327/full/v20/i1/91.htm
PMID	24415861
PQID	1501370801
PQPubID	23479
PageCount	9
ParticipantIDs	pubmedcentral_primary_oai_pubmedcentral_nih_gov_3886036 proquest_miscellaneous_1501370801 pubmed_primary_24415861 crossref_citationtrail_10_3748_wjg_v20_i1_91 crossref_primary_10_3748_wjg_v20_i1_91 chongqing_primary_90888889504849524849484949
ProviderPackageCode	CITATION AAYXX
PublicationCentury	2000
PublicationDate	2014-01-07
PublicationDateYYYYMMDD	2014-01-07
PublicationDate_xml	– month: 01 year: 2014 text: 2014-01-07 day: 07
PublicationDecade	2010
PublicationPlace	United States
PublicationPlace_xml	– name: United States
PublicationTitle	World journal of gastroenterology : WJG
PublicationTitleAlternate	World Journal of Gastroenterology
PublicationYear	2014
Publisher	Baishideng Publishing Group Co., Limited
Publisher_xml	– name: Baishideng Publishing Group Co., Limited
References	15168363 - Gastroenterology. 2004 May;126(6):1504-17 17581537 - Nat Immunol. 2007 Sep;8(9):967-74 17119388 - Inflamm Bowel Dis. 2006 Dec;12(12):1136-45 21287671 - Inflamm Bowel Dis. 2011 Nov;17(11):2358-65 19701189 - Nat Immunol. 2009 Oct;10(10):1073-80 16937461 - World J Gastroenterol. 2006 Aug 14;12(30):4807-12 19740775 - Gut. 2009 Dec;58(12):1629-36 19114665 - J Exp Med. 2009 Jan 16;206(1):35-41 21209126 - Gut. 2011 May;60(5):631-7 15831718 - Science. 2005 Jun 10;308(5728):1635-8 16083712 - Gastroenterology. 2005 Aug;129(2):550-64 20186935 - Inflamm Bowel Dis. 2010 Aug;16(8):1332-9 15626903 - Inflamm Bowel Dis. 2004 Nov;10(6):848-59 19132915 - Annu Rev Immunol. 2009;27:485-517 21251876 - Trends Immunol. 2011 Feb;32(2):73-9 18653729 - Gut. 2008 Dec;57(12):1682-9 18816683 - Inflamm Bowel Dis. 2008 Oct;14 Suppl 2:S14-5 23128233 - Nature. 2012 Nov 1;491(7422):119-24 17068223 - Science. 2006 Dec 1;314(5804):1461-3 16831596 - Gastroenterology. 2006 Jul;131(1):117-29 22539302 - Eur J Immunol. 2012 May;42(5):1337-53 15307874 - Am J Gastroenterol. 2004 Aug;99(8):1539-43 15479689 - Gut. 2004 Nov;53(11):1658-64 16162953 - Gut. 2005 Oct;54(10):1481-91 15157822 - Best Pract Res Clin Gastroenterol. 2004 Jun;18(3):481-96 22375527 - Expert Rev Gastroenterol Hepatol. 2012 Apr;6(2):223-37 18852889 - PLoS One. 2008;3(10):e3391 19966812 - Nat Med. 2010 Jan;16(1):90-7 15146247 - J Clin Invest. 2004 May;113(10):1490-7 17223928 - Cell Microbiol. 2007 May;9(5):1252-61 22686333 - Aliment Pharmacol Ther. 2012 Aug;36(4):324-44 20089077 - Clin Exp Immunol. 2010 Jun;160(3):386-93 20940708 - Am J Gastroenterol. 2010 Dec;105(12):2687-92 18390994 - Gut. 2008 Oct;57(10):1386-92 19592695 - Gut. 2009 Aug;58(8):1152-67 18069751 - World J Gastroenterol. 2007 Dec 14;13(46):6134-9 21328288 - Cochrane Database Syst Rev. 2011;(2):CD006913 20203603 - Nature. 2010 Mar 4;464(7285):59-65 22393130 - Ann Intern Med. 2012 Mar 6;156(5):350-9 15905709 - Inflamm Bowel Dis. 2005 Jun;11(6):600-8 19349988 - Nat Immunol. 2009 May;10(5):471-9 17602969 - Semin Pediatr Surg. 2007 Aug;16(3):146-53 21102463 - Nat Genet. 2010 Dec;42(12):1118-25 21253779 - J Gastroenterol. 2011 Apr;46(4):479-86 12167685 - N Engl J Med. 2002 Aug 8;347(6):417-29 17653185 - Nature. 2007 Jul 26;448(7152):427-34 11385577 - Nature. 2001 May 31;411(6837):603-6 19086963 - Am J Gastroenterol. 2008 Dec;103(12):3167-82 16048556 - Immunol Rev. 2005 Aug;206:296-305 20588264 - Am J Gastroenterol. 2010 Nov;105(11):2412-9 17484863 - Gastroenterology. 2007 May;132(5):1657-64 17200669 - Nat Genet. 2007 Feb;39(2):207-11 11053501 - J Nutr. 2000 Nov;130(11):2648-52 16631883 - Lancet. 2006 Apr 15;367(9518):1271-84 15472520 - Inflamm Bowel Dis. 2004 Sep;10(5):593-8 22223662 - Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1193-8 10922424 - N Engl J Med. 2000 Aug 3;343(5):338-44 21530740 - Gastroenterology. 2011 May;140(6):1738-47 15220916 - Nat Immunol. 2004 Aug;5(8):800-8 19165925 - Nat Genet. 2008 Sep;40(9):1107-12 12514169 - J Biol Chem. 2003 Feb 21;278(8):5509-12 19898471 - Nat Immunol. 2010 Jan;11(1):55-62 11549540 - Am J Respir Crit Care Med. 2001 Sep 1;164(5):826-30 16804402 - Inflamm Bowel Dis. 2006 Jul;12(7):641-50 17484895 - Gastroenterology. 2007 May;132(5):2045-9 17699621 - Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13780-5 19923578 - N Engl J Med. 2009 Nov 19;361(21):2066-78 12512038 - Gastroenterology. 2003 Jan;124(1):140-6 20951137 - Gastroenterology. 2011 Jan;140(1):254-64 21297633 - Nat Genet. 2011 Mar;43(3):246-52 18422819 - Am J Gastroenterol. 2008 Jun;103(6):1451-9 17709955 - Neuroimmunomodulation. 2006;13(5-6):327-36 15765404 - Gastroenterology. 2005 Mar;128(3):687-94 16861666 - Infect Immun. 2006 Aug;74(8):4778-92 21983784 - Nat Genet. 2011 Nov;43(11):1066-73 22234954 - Inflamm Bowel Dis. 2012 Jul;18(7):1232-9 18806221 - Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):15064-9 20806342 - Inflamm Bowel Dis. 2011 May;17(5):1138-45 12902844 - Inflamm Bowel Dis. 2003 Jul;9(4):215-23 18395085 - Gastroenterology. 2008 Apr;134(4):1038-48 16048555 - Immunol Rev. 2005 Aug;206:277-95 10764314 - Am J Respir Crit Care Med. 2000 Apr;161(4 Pt 1):1213-7 15082587 - Gut. 2004 May;53(5):685-93 8436398 - Immunology. 1993 Jan;78(1):127-31 21151126 - Nat Genet. 2011 Jan;43(1):43-7 11023669 - Cytokine. 2000 Oct;12(10):1531-6 15814663 - J Immunol. 2005 Apr 15;174(8):4453-60 16503465 - Lancet. 2006 Feb 25;367(9511):668-78 18341488 - Am J Gastroenterol. 2008 Mar;103(3):643-8 21538717 - Inflamm Bowel Dis. 2012 Feb;18(2):368-71 17435756 - Nat Genet. 2007 May;39(5):596-604 21677747 - Nature. 2011 Jun 16;474(7351):307-17 20725949 - Inflamm Bowel Dis. 2011 Jan;17(1):362-81
References_xml	– reference: 18069751 - World J Gastroenterol. 2007 Dec 14;13(46):6134-9 – reference: 21530740 - Gastroenterology. 2011 May;140(6):1738-47 – reference: 21287671 - Inflamm Bowel Dis. 2011 Nov;17(11):2358-65 – reference: 17435756 - Nat Genet. 2007 May;39(5):596-604 – reference: 18653729 - Gut. 2008 Dec;57(12):1682-9 – reference: 17699621 - Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13780-5 – reference: 11549540 - Am J Respir Crit Care Med. 2001 Sep 1;164(5):826-30 – reference: 17484895 - Gastroenterology. 2007 May;132(5):2045-9 – reference: 23128233 - Nature. 2012 Nov 1;491(7422):119-24 – reference: 15765404 - Gastroenterology. 2005 Mar;128(3):687-94 – reference: 15831718 - Science. 2005 Jun 10;308(5728):1635-8 – reference: 22234954 - Inflamm Bowel Dis. 2012 Jul;18(7):1232-9 – reference: 21253779 - J Gastroenterol. 2011 Apr;46(4):479-86 – reference: 22539302 - Eur J Immunol. 2012 May;42(5):1337-53 – reference: 12902844 - Inflamm Bowel Dis. 2003 Jul;9(4):215-23 – reference: 19114665 - J Exp Med. 2009 Jan 16;206(1):35-41 – reference: 21151126 - Nat Genet. 2011 Jan;43(1):43-7 – reference: 21251876 - Trends Immunol. 2011 Feb;32(2):73-9 – reference: 21328288 - Cochrane Database Syst Rev. 2011;(2):CD006913 – reference: 19592695 - Gut. 2009 Aug;58(8):1152-67 – reference: 21209126 - Gut. 2011 May;60(5):631-7 – reference: 22223662 - Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1193-8 – reference: 17484863 - Gastroenterology. 2007 May;132(5):1657-64 – reference: 19349988 - Nat Immunol. 2009 May;10(5):471-9 – reference: 12514169 - J Biol Chem. 2003 Feb 21;278(8):5509-12 – reference: 16631883 - Lancet. 2006 Apr 15;367(9518):1271-84 – reference: 11023669 - Cytokine. 2000 Oct;12(10):1531-6 – reference: 16162953 - Gut. 2005 Oct;54(10):1481-91 – reference: 16861666 - Infect Immun. 2006 Aug;74(8):4778-92 – reference: 17602969 - Semin Pediatr Surg. 2007 Aug;16(3):146-53 – reference: 12512038 - Gastroenterology. 2003 Jan;124(1):140-6 – reference: 18852889 - PLoS One. 2008;3(10):e3391 – reference: 20940708 - Am J Gastroenterol. 2010 Dec;105(12):2687-92 – reference: 20951137 - Gastroenterology. 2011 Jan;140(1):254-64 – reference: 19740775 - Gut. 2009 Dec;58(12):1629-36 – reference: 20588264 - Am J Gastroenterol. 2010 Nov;105(11):2412-9 – reference: 20089077 - Clin Exp Immunol. 2010 Jun;160(3):386-93 – reference: 15472520 - Inflamm Bowel Dis. 2004 Sep;10(5):593-8 – reference: 18422819 - Am J Gastroenterol. 2008 Jun;103(6):1451-9 – reference: 17200669 - Nat Genet. 2007 Feb;39(2):207-11 – reference: 19701189 - Nat Immunol. 2009 Oct;10(10):1073-80 – reference: 21102463 - Nat Genet. 2010 Dec;42(12):1118-25 – reference: 15220916 - Nat Immunol. 2004 Aug;5(8):800-8 – reference: 15168363 - Gastroenterology. 2004 May;126(6):1504-17 – reference: 17223928 - Cell Microbiol. 2007 May;9(5):1252-61 – reference: 20203603 - Nature. 2010 Mar 4;464(7285):59-65 – reference: 11385577 - Nature. 2001 May 31;411(6837):603-6 – reference: 16804402 - Inflamm Bowel Dis. 2006 Jul;12(7):641-50 – reference: 22686333 - Aliment Pharmacol Ther. 2012 Aug;36(4):324-44 – reference: 10922424 - N Engl J Med. 2000 Aug 3;343(5):338-44 – reference: 19923578 - N Engl J Med. 2009 Nov 19;361(21):2066-78 – reference: 20186935 - Inflamm Bowel Dis. 2010 Aug;16(8):1332-9 – reference: 22393130 - Ann Intern Med. 2012 Mar 6;156(5):350-9 – reference: 16083712 - Gastroenterology. 2005 Aug;129(2):550-64 – reference: 17119388 - Inflamm Bowel Dis. 2006 Dec;12(12):1136-45 – reference: 21677747 - Nature. 2011 Jun 16;474(7351):307-17 – reference: 15905709 - Inflamm Bowel Dis. 2005 Jun;11(6):600-8 – reference: 18390994 - Gut. 2008 Oct;57(10):1386-92 – reference: 20725949 - Inflamm Bowel Dis. 2011 Jan;17(1):362-81 – reference: 15626903 - Inflamm Bowel Dis. 2004 Nov;10(6):848-59 – reference: 17653185 - Nature. 2007 Jul 26;448(7152):427-34 – reference: 19966812 - Nat Med. 2010 Jan;16(1):90-7 – reference: 21983784 - Nat Genet. 2011 Nov;43(11):1066-73 – reference: 18806221 - Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):15064-9 – reference: 21538717 - Inflamm Bowel Dis. 2012 Feb;18(2):368-71 – reference: 16831596 - Gastroenterology. 2006 Jul;131(1):117-29 – reference: 18341488 - Am J Gastroenterol. 2008 Mar;103(3):643-8 – reference: 19086963 - Am J Gastroenterol. 2008 Dec;103(12):3167-82 – reference: 12167685 - N Engl J Med. 2002 Aug 8;347(6):417-29 – reference: 21297633 - Nat Genet. 2011 Mar;43(3):246-52 – reference: 18816683 - Inflamm Bowel Dis. 2008 Oct;14 Suppl 2:S14-5 – reference: 19898471 - Nat Immunol. 2010 Jan;11(1):55-62 – reference: 10764314 - Am J Respir Crit Care Med. 2000 Apr;161(4 Pt 1):1213-7 – reference: 16503465 - Lancet. 2006 Feb 25;367(9511):668-78 – reference: 17581537 - Nat Immunol. 2007 Sep;8(9):967-74 – reference: 15814663 - J Immunol. 2005 Apr 15;174(8):4453-60 – reference: 17068223 - Science. 2006 Dec 1;314(5804):1461-3 – reference: 19132915 - Annu Rev Immunol. 2009;27:485-517 – reference: 16048555 - Immunol Rev. 2005 Aug;206:277-95 – reference: 16937461 - World J Gastroenterol. 2006 Aug 14;12(30):4807-12 – reference: 15479689 - Gut. 2004 Nov;53(11):1658-64 – reference: 8436398 - Immunology. 1993 Jan;78(1):127-31 – reference: 16048556 - Immunol Rev. 2005 Aug;206:296-305 – reference: 18395085 - Gastroenterology. 2008 Apr;134(4):1038-48 – reference: 15146247 - J Clin Invest. 2004 May;113(10):1490-7 – reference: 19165925 - Nat Genet. 2008 Sep;40(9):1107-12 – reference: 15307874 - Am J Gastroenterol. 2004 Aug;99(8):1539-43 – reference: 17709955 - Neuroimmunomodulation. 2006;13(5-6):327-36 – reference: 20806342 - Inflamm Bowel Dis. 2011 May;17(5):1138-45 – reference: 15082587 - Gut. 2004 May;53(5):685-93 – reference: 15157822 - Best Pract Res Clin Gastroenterol. 2004 Jun;18(3):481-96 – reference: 11053501 - J Nutr. 2000 Nov;130(11):2648-52 – reference: 22375527 - Expert Rev Gastroenterol Hepatol. 2012 Apr;6(2):223-37
SSID	ssj0023352
Score	2.6197937
SecondaryResourceType	review_article
Snippet	Inflammatory bowel disease(IBD),including Crohn’s disease and ulcerative colitis,is characterized by chronic relapsing intestinal inflammation.It has been a... Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is characterized by chronic relapsing intestinal inflammation. It has been... Inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, is characterized by chronic relapsing intestinal inflammation. It has been...
SourceID	pubmedcentral proquest pubmed crossref chongqing
SourceType	Open Access Repository Aggregation Database Index Database Enrichment Source Publisher
StartPage	91
SubjectTerms	Adaptive Immunity Animals bowel colitis Croh disease Environment Genetic Predisposition to Disease Humans Immunity, Innate Inflammatory Inflammatory Bowel Diseases - etiology Inflammatory Bowel Diseases - genetics Inflammatory Bowel Diseases - immunology Inflammatory Bowel Diseases - microbiology Intestines - immunology Intestines - microbiology Prognosis Risk Factors Topic Highlight Ulcerative
Title	Inflammatory bowel disease:Pathogenesis
URI	http://lib.cqvip.com/qk/84123X/201401/90888889504849524849484949.html https://www.ncbi.nlm.nih.gov/pubmed/24415861 https://www.proquest.com/docview/1501370801 https://pubmed.ncbi.nlm.nih.gov/PMC3886036
Volume	20
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELdgvPCCQHyODxUJw0NJyUed2Ly1XauBAPFQpI2XyE6dNghSYC2T-Ov5nZNm6cokRtVakX0-N3eX8905PjP2LMOkn8yS2BM21x4UnvCM9JVHa0h6prWQLg75_kN8-Kn_9kgcnUWV3O6Slellv_-6r-R_uIo68JV2yV6Csw1SVOAa_EUJDqP8Jx6_KXMw9Fu1UG6Wp7ZZcAGGj7DtlnNSZcVJ2wTl4z4fSq5iPk64ElyO-FhyGdGXLkI-8F1TwqXgY8EHB3wA4JirA2pFzXBCreMJH464GrheQz4MHEzMZULdpeJS1jB0AYQYd4NQ-TswTUTiuPA-L2zZdbHs7vGynHvH6-67oh2gCPouQJG0dCpFQ2EmVlXW1YVQlB5mRn9HxCo9Wp3gVc_I1QlK53U95c0Bg06_zHu_Qr9XBL1Np6302fQeFz5KQFXBGQypdD91lV0L4VtEmxBP7aXTJjS3RF7_6yoxK432amssSsaxAAl-wMTYNmp2PJXzL9y2LJjpTXajdj06g0qObrErtrzNXrRlqONkqFPL0Ou2BN1h08l4Ojr06sMzvAw24cqbCZVbX2eqb2KhYXfOcu0b3ygYRZGQUa5NkpNzncQ2iXWgZ34G2zazsQENdHSX7ZXL0t5nHVDEgF9BZAx8-chCZUdwA4QK8zBLZPCAvWwIkX6vcqSkF5OdwGtapVmdh56OQ_mawh8lMqcgcwoyp0WQKmB_3oBvkF8A-HRD-BQqkta9dGmX65MUPg9uE64RYO5VjGhQhRRPkDFaki0WNQCUfn27pSwWLg17JGUM-2__crf_kF0_e0gesb3Vz7V9DLt2ZZ44OfwDg3yJGg
linkProvider	National Library of Medicine
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Inflammatory+bowel+disease%3APathogenesis&rft.jtitle=%E4%B8%96%E7%95%8C%E8%83%83%E8%82%A0%E7%97%85%E5%AD%A6%E6%9D%82%E5%BF%97%EF%BC%9A%E8%8B%B1%E6%96%87%E7%89%88%EF%BC%88%E7%94%B5%E5%AD%90%E7%89%88%EF%BC%89&rft.au=Yi-Zhen+Zhang+Yong-Yu+Li&rft.date=2014-01-07&rft.issn=1007-9327&rft.eissn=2219-2840&rft.issue=1&rft.spage=91&rft.epage=99&rft_id=info:doi/10.3748%2Fwjg.v20.i1.91&rft.externalDocID=90888889504849524849484949
thumbnail_s	http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fimage.cqvip.com%2Fvip1000%2Fqk%2F84123X%2F84123X.jpg