Induction of Anti-Aquaporin 5 Autoantibody Production by Immunization with a Peptide Derived from the Aquaporin of Prevotella melaninogenica Leads to Reduced Salivary Flow in Mice

• Published in: Immune network Vol. 21; no. 5; pp. 34 - 49
• Main Authors: Lee, Ahreum, Yoo, Duck Kyun, Lee, Yonghee, Jeon, Sumin, Jung, Suhan, Noh, Jinsung, Ju, Soyeon, Hwang, Siwon, Kim, Hong Hee, Kwon, Sunghoon, Chung, Junho, Choi, Youngnim
• Format: Journal Article
• Language: English
• Published: 대한면역학회 01.10.2021; The Korean Association of Immunologists
• Subjects: Original; 면역학; Molecular mimicry; Mice; Autoantibodies; Aquaporin-5; Sjogren"s syndrome

Sjögren's syndrome (SS) is an autoimmune disease characterized by dryness of the mouth and eyes. The glandular dysfunction in SS involves not only T cell-mediated destruction of the glands but also autoantibodies against the type 3 muscarinic acetylcholine receptor or aquaporin 5 (AQP5) that in...