Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in the Subretinal Space of the Cat Eye

• Published in: Stem cells and development Vol. 28; no. 17; pp. 1151 - 1166
• Main Authors: Singh, Ratnesh K., Occelli, Laurence M., Binette, Francois, Petersen-Jones, Simon M., Nasonkin, Igor O.
• Format: Journal Article
• Language: English
• Published: United States Mary Ann Liebert, Inc., publishers 01.09.2019
• Subjects: Original Research Reports; large-eye animal models; synaptic connectivity; vision restoration; retinal organoids; human embryonic stem cells; subretinal transplantation

To develop biological approaches to restore vision, we developed a method of transplanting stem cell-derived retinal tissue into the subretinal space of a large-eye animal model (cat). Human embryonic stem cells (hESC) were differentiated to retinal organoids in a dish. hESC-derived retinal tissue w...