Cordycepin inhibits pancreatic cancer cell growth in vitro and in vivo via targeting FGFR2 and blocking ERK signaling - LI, Xue-Ying; TAO, Homng; JIN, Can; DU, Zhen-Yun; LIAO, Wen-Feng; TANG, Qing-Jiu; DING, Kan (Chinese journal of natural medicines, 2020)
Keywords: Animals; antineoplastic activity; Apoptosis; Apoptosis - drug effects; caspase-3; caspase-9; cell cycle checkpoints; Cell Cycle Checkpoints - drug effects; cell growth; Cell Line, Tumor; Cell Proliferation - drug effects; Cordycepin; Cordyceps - chemistry; Cordyceps militaris; cyclin-dependent kinase; cyclins; Deoxyadenosines - administration & dosage; DNA damage; drug development; Drugs, Chinese Herbal - administration & dosage; Female; FGFR2; fibroblast growth factor receptor 2; Humans; MAP Kinase Signaling System - drug effects; Mice; Mice, Inbred BALB C; neoplasm cells; Pancreatic cancer; pancreatic neoplasms; Pancreatic Neoplasms - drug therapy; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - metabolism; Pancreatic Neoplasms - physiopathology; phosphorylation; Ras/Erk; Receptor, Fibroblast Growth Factor, Type 2 - genetics; Receptor, Fibroblast Growth Factor, Type 2 - metabolism; Ras/Erk; Pancreatic cancer; Cordycepin; FGFR2; Apoptosis