High plasma apolipoprotein B identifies obese subjects who best ameliorate white adipose tissue dysfunction and glucose-induced hyperinsulinemia after a hypocaloric diet

• Published in: The American journal of clinical nutrition Vol. 108; no. 1; pp. 62 - 76
• Main Authors: Bissonnette, Simon, Saint -Pierre, Nathalie, Lamantia, Valerie, Leroux, Catherine, Provost, Viviane, Cyr, Yannick, Rabasa -Lhoret, Remi, Faraj, May
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2018; Oxford University Press; American Society for Clinical Nutrition, Inc
• Subjects: Adipose tissue; Adipose Tissue, White - metabolism; Apolipoprotein B; Apolipoproteins B - blood; Body composition; Body mass; Body mass index; Body size; Botnia clamp; Cholesterol; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diet; Energy intake; Energy Intake - physiology; Female; Gender aspects; Glucose; Glucose - pharmacology; Glucose tolerance; Health risks; High density lipoprotein; Humans; Hyper-apoB; Hyperinsulinemia; Hyperinsulinism - blood; Hypertriglyceridemia; Hypocaloric diet; Insulin; Insulin - metabolism; Insulin resistance; insulin sensitivity and secretion; Intravenous administration; Lipoproteins; Low density lipoprotein; Male; Middle Aged; Obesity; Obesity - metabolism; Optimization; overweight and obese subjects; plasma apoB lipoproteins; Post-menopause; postprandial fat clearance; Postprandial Period; Prevention; Risk analysis; Risk Factors; risk factors for type 2 diabetes; Secretion; Sex; Sex differences; Triolein; weight loss; white adipose tissue function; M/I; LPL; Hyper-apoB; WAT; plasma apoB lipoproteins; TRL; iAUC6h; overweight and obese subjects; IVGTT; NEFA; postprandial fat clearance; hypocaloric diet; apo; Botnia clamp; T2D; weight loss; IR; IS; GIIS; risk factors for type 2 diabetes; GIR; IRCM; TG; insulin sensitivity and secretion; white adipose tissue function

To optimize the prevention of type 2 diabetes (T2D), high-risk obese subjects with the best metabolic recovery after a hypocaloric diet should be targeted. Apolipoprotein B lipoproteins (apoB lipoproteins) induce white adipose tissue (WAT) dysfunction, which in turn promotes postprandial hypertrigly...