Combined cerebral atrophy score in Huntington's disease based on atlas-based MRI volumetry: Sample size calculations for clinical trials

• Published in: Parkinsonism & related disorders Vol. 63; pp. 179 - 184
• Main Authors: Müller, Hans-Peter, Huppertz, Hans-Jürgen, Dreyhaupt, Jens, Ludolph, Albert C., Tabrizi, Sarah J., Roos, Raymund A.C., Durr, Alexandra, Landwehrmeyer, G. Bernhard, Kassubek, Jan
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2019
• Subjects: Adult; Aged; Atlas-based volumetry; Atlases as Topic; Atrophy - pathology; Biomarkers; Clinical trial; Clinical Trials as Topic - methods; Effect size; Female; Humans; Huntington Disease - diagnostic imaging; Huntington Disease - pathology; Huntington's disease; Longitudinal Studies; Longitudinal study; Magnetic Resonance Imaging; Male; Middle Aged; Multicenter study; Neuroimaging - methods; Surrogate marker; Young Adult; Effect size; Multicenter study; Longitudinal study; Surrogate marker; Clinical trial; Atlas-based volumetry; Huntington's disease

A volumetric MRI analysis of longitudinal regional cerebral atrophy in Huntington's disease (HD) was performed as a read-out of disease progression to calculate sample sizes for future clinical trials. This study was based on MRI data of 59 patients with HD and 40 controls recruited within the...