Rapamycin Increases the Development Competence of Yak (Bos grunniens) Oocytes by Promoting Autophagy via Upregulating 17β-Estradiol and HIF-1α During In Vitro Maturation

• Published in: Animals (Basel) Vol. 15; no. 3; p. 365
• Main Authors: Wang, Meng, Ma, Xin, Zhang, Qian, Zhang, Hui, Qiu, Shantong, Xu, Ruihua, Pan, Yangyang
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 27.01.2025; MDPI
• Subjects: Analysis; Apoptosis; Autophagy; Cytochrome; DNA damage; E2 synthesis; Embryonic development; Embryos; Enzyme-linked immunosorbent assay; Enzymes; Estradiol; Estrogens; HIF-1α; Hormones; Hydroxylases; Hypoxia; In vitro fertilization; oocyte maturation; Phenols; Physiology; Pulmonary arteries; Rapamycin; Reactive oxygen species; yak; United States; China; United States > US; yak; HIF-1α; autophagy; oocyte maturation; E2 synthesis; rapamycin
• ISSN: 2076-2615; 2076-2615
• DOI: 10.3390/ani15030365

High-quality oocyte production strategies play an important role in animal-assisted reproductive biotechnologies, and rapamycin (Rap) has been commonly used to increase the development potential of mammalian oocytes. The purpose of this study is to evaluate the effects and possible molecular mechani...