New benzoate derivatives and hirsutane type sesquiterpenoids with antimicrobial activity and cytotoxicity from the solid-state fermented rice by the medicinal mushroom Stereum hirsutum

• Published in: Food chemistry Vol. 143; pp. 239 - 245
• Main Authors: Ma, Ke, Bao, Li, Han, Junjie, Jin, Tao, Yang, Xiaoli, Zhao, Feng, Li, Shaifei, Song, Fuhang, Liu, Miaomiao, Liu, Hongwei
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 15.01.2014; Elsevier
• Subjects: Agaricales - chemistry; Agaricales - metabolism; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - metabolism; Anti-Bacterial Agents - pharmacology; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Benzoate esters; Benzoates - chemistry; Benzoates - metabolism; Benzoates - pharmacology; Biological and medical sciences; Cell Line; Cytotoxicity; Cytotoxins - chemistry; Cytotoxins - metabolism; Cytotoxins - pharmacology; Fermentation; Functional Food - analysis; Hirsutane sesquiterpenoids; Humans; Medical sciences; Molecular Structure; NO inhibition; Oryza - metabolism; Oryza - microbiology; Oryza sativa; Pharmacology. Drug treatments; Sesquiterpenes - chemistry; Sesquiterpenes - metabolism; Sesquiterpenes - pharmacology; Staphylococcus - drug effects; Stereum hirsutum; Hirsutane sesquiterpenoids; Cytotoxicity; NO inhibition; Stereum hirsutum; Benzoate esters; Antimicrobial agent; Basidiomycota; Fungi; Ester; Cereal; Inhibition; Antibacterial agent; Food; Rice

•The edible and medicinal mushroom Stereum hirsutum was fermented on rice.•Two new benzoate esters and three new sesquiterpenes were purified and identified.•The absolute configuration of compound 3 was assigned by X-ray.•New benzoate esters (1 and 2) showed moderate antimicrobial activity.•New sesq...