Refinement of the modified-relative-dose-response test as a method for assessing vitamin A status in a field setting: experience with Indonesian children
The modified-relative-dose-response (MRDR) test, which has been used extensively throughout the world for assessing vitamin A status, has been simplified. The major methodologic change resulting from the current studies in Indonesia is the use of graded standard doses of 3,4-didehydroretinyl acetate...
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Published in | The American journal of clinical nutrition Vol. 64; no. 6; pp. 966 - 971 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Bethesda, MD
Elsevier Inc
01.12.1996
American Society for Clinical Nutrition American Society for Clinical Nutrition, Inc |
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Abstract | The modified-relative-dose-response (MRDR) test, which has been used extensively throughout the world for assessing vitamin A status, has been simplified. The major methodologic change resulting from the current studies in Indonesia is the use of graded standard doses of 3,4-didehydroretinyl acetate (DRA) based on the age range of the population of interest. Instead of a dose of 0.35 mumol/kg body wt, standard doses of 5.3 mumol for children younger than 6 y, 7.0 mumol for children between 6 and 12 y of age, and 8.8 mumol for adults and children > 12 y of age are suggested for field use. The acceptable time between administering the oral dose and obtaining a blood sample was validated as being 4–7 h in a group of children (n = 84) by taking two blood samples per child between 3 and 7 h after dosing with DRA. Furthermore, DRA in vitamin E-containing corn oil, with or without the addition of 4.6 mmol all-rac-alpha-tocopheryl acetate/L, was found to be stable for > or = 18 mo at 2 degrees C and at -20 degrees C, but not at 22 degrees C or at 37 degrees C. When DRA was stored in amber glass vials, stability was affected more by temperature than by exposure to room light. In keeping with earlier studies in adults, the ratio of 3,4-didehydro-retinol to retino tends to be independent of body weight. Indeed, slower growing children (ie, those with lower weight-for-age) may have a somewhat better vitamin A status than their heavier counterparts. |
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AbstractList | The modified-relative-dose-response (MRDR) test, which has been used extensively throughout the world for assessing vitamin A status, has been simplified. The major methodologic change resulting from the current studies in Indonesia is the use of graded standard doses of 3,4-didehydroretinyl acetate (DRA) based on the age range of the population of interest. Instead of a dose of 0.35 mumol/kg body wt, standard doses of 5.3 mumol for children younger than 6 y, 7.0 mumol for children between 6 and 12 y of age, and 8.8 mumol for adults and children > 12 y of age are suggested for field use. The acceptable time between administering the oral dose and obtaining a blood sample was validated as being 4-7 h in a group of children (n = 84) by taking two blood samples per child between 3 and 7 h after dosing with DRA. Furthermore, DRA in vitamin E-containing corn oil, with or without the addition of 4.6 mmol all-rac-alpha-tocopheryl acetate/L, was found to be stable for > or = 18 mo at 2 degrees C and at -20 degrees C, but not at 22 degrees C or at 37 degrees C. When DRA was stored in amber glass vials, stability was affected more by temperature than by exposure to room light. In keeping with earlier studies in adults, the ratio of 3,4-didehydro-retinol to retino tends to be independent of body weight. Indeed, slower growing children (ie, those with lower weight-for-age) may have a somewhat better vitamin A status than their heavier counterparts. The modified-relative-dose-response (MRDR) test, which has been used extensively throughout the world for assessing vitamin A status, has been simplified. The major methodologic change resulting from the current studies in Indonesia is the use of graded standard doses of 3,4-didehydroretinyl acetate (DRA) based on the age range of the population of interest. Instead of a dose of 0.35 mumol/kg body wt, standard doses of 5.3 mumol for children younger than 6 y, 7.0 mumol for children between 6 and 12 y of age, and 8.8 mumol for adults and children > 12 y of age are suggested for field use. The acceptable time between administering the oral dose and obtaining a blood sample was validated as being 4-7 h in a group of children (n = 84) by taking two blood samples per child between 3 and 7 h after dosing with DRA. Furthermore, DRA in vitamin E-containing corn oil, with or without the addition of 4.6 mmol all-rac-alpha-tocopheryl acetate/L, was found to be stable for > or = 18 mo at 2 degrees C and at -20 degrees C, but not at 22 degrees C or at 37 degrees C. When DRA was stored in amber glass vials, stability was affected more by temperature than by exposure to room light. In keeping with earlier studies in adults, the ratio of 3,4-didehydro-retinol to retino tends to be independent of body weight. Indeed, slower growing children (ie, those with lower weight-for-age) may have a somewhat better vitamin A status than their heavier counterparts. The modified-relative-dose-response (MRDR) test, which has been used extensively throughout the world for assessing vitamin A status, has been simplified. The major methodologic change resulting from the current studies in Indonesia is the use of graded standard doses of 3,4-didehydroretinyl acetate (DRA) based on the age range of the population of interest. |
Author | Permaesih, D Muherdiyantiningsih Karyadi, D Olson, JA Tanumihardjo, SA Cheng, JC Rustan, E Muhilal |
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Cites_doi | 10.1093/ajcn/60.1.136 10.1016/S0040-4039(01)85279-5 10.1093/ajcn/63.1.32 10.1093/ajcn/60.1.142 10.1093/jn/126.2.451 10.1093/ajcn/61.6.1253 |
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publication-title: Int J Vitam Nutr Res contributor: fullname: Tanumihardjo – volume: 60 start-page: 142 year: 1994 ident: 10.1093/ajcn/64.6.966_bib2 article-title: Assessment of the vitamin A status in lactating and nonlactating, nonpregnant Indonesian women by use of the modified-relative-dose-response (MRDR) test. publication-title: Am J Clin Nutr doi: 10.1093/ajcn/60.1.142 contributor: fullname: Tanumihardjo – volume: 49 start-page: 897 year: 1995 ident: 10.1093/ajcn/64.6.966_bib3 article-title: Application of the modified relative dose response (MRDR) test to pregnant Indonesian women for assessing vitamin A status. publication-title: Eur J Clin Nutr contributor: fullname: Tanumihardjo – volume: 126 start-page: 451 year: 1996 ident: 10.1093/ajcn/64.6.966_bib5 article-title: Vitamin A status of Indonesian children infected with Ascaris lumbricoides after dosing with vitamin A supplements and albendazole. publication-title: J Nutr doi: 10.1093/jn/126.2.451 contributor: fullname: Tanumihardjo – year: 1995 ident: 10.1093/ajcn/64.6.966_bib9 article-title: Survey of vitamin A deficiency in preschool children of 5 lower Southern Provinces. contributor: fullname: Sinawat – volume: 61 start-page: 1253 year: 1995 ident: 10.1093/ajcn/64.6.966_bib10 article-title: Comparison of the modified relative dose response (MRDR) and the relative dose response (RDR) in the assessment of vitamin A status in malnourished children. publication-title: Am J Clin Nutr doi: 10.1093/ajcn/61.6.1253 contributor: fullname: Wahed |
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SubjectTerms | Adult Analytical, structural and metabolic biochemistry Biological and medical sciences Body Weight - physiology Child Child, Preschool Coenzymes, vitamins Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Humans Indonesia - epidemiology Investigative techniques, diagnostic techniques (general aspects) Malnutrition Medical sciences Metabolic diseases Other biological molecules Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Tests Vitamin A Vitamin A - analogs & derivatives Vitamin A - blood Vitamin A Deficiency - blood Vitamin A Deficiency - diagnosis Vitamin A Deficiency - epidemiology |
Title | Refinement of the modified-relative-dose-response test as a method for assessing vitamin A status in a field setting: experience with Indonesian children |
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