Hyperactive CREB signaling pathway involved in the pathogenesis of polycystic ovarian syndrome revealed by patient-specific induced pluripotent stem cell modeling

• Published in: Fertility and sterility Vol. 112; no. 3; pp. 594 - 607.e12
• Main Authors: Huang, Chu-Chun, Chen, Mei-Jou, Lan, Chen-Wei, Wu, Chia-Eng, Huang, Mei-Chi, Kuo, Hung-Chih, Ho, Hong-Nerng
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2019
• Subjects: Animals; Case-Control Studies; Cells, Cultured; CREB; Cyclic AMP Response Element-Binding Protein - genetics; Cyclic AMP Response Element-Binding Protein - metabolism; DNA methylation; Female; granulosa cells; Humans; Induced Pluripotent Stem Cells - metabolism; iPSC; Mice; Mice, Inbred NOD; Mice, SCID; Microarray Analysis - methods; Oocyte Retrieval - methods; PCOS; Polycystic Ovary Syndrome - genetics; Polycystic Ovary Syndrome - metabolism; Polycystic Ovary Syndrome - pathology; Signal Transduction - physiology; DNA methylation; PCOS; CREB; granulosa cells; iPSC

To study whether and how the pathogenesis of polycystic ovarian syndrome (PCOS) is related to epigenetic aberrations. A case-control experimental study. Tertiary university hospital. Eighteen patients with PCOS and ten non-PCOS control subjects. Patient-specific induced pluripotent stem cells (iPSCs...