Hyperactive CREB signaling pathway involved in the pathogenesis of polycystic ovarian syndrome revealed by patient-specific induced pluripotent stem cell modeling - Huang, Chu-Chun; Chen, Mei-Jou; Lan, Chen-Wei; Wu, Chia-Eng; Huang, Mei-Chi; Kuo, Hung-Chih; Ho, Hong-Nerng (Fertility and sterility, 2019)
Keywords: Animals; Case-Control Studies; Cells, Cultured; CREB; Cyclic AMP Response Element-Binding Protein - genetics; Cyclic AMP Response Element-Binding Protein - metabolism; DNA methylation; Female; granulosa cells; Humans; Induced Pluripotent Stem Cells - metabolism; iPSC; Mice; Mice, Inbred NOD; Mice, SCID; Microarray Analysis - methods; Oocyte Retrieval - methods; PCOS; Polycystic Ovary Syndrome - genetics; Polycystic Ovary Syndrome - metabolism; Polycystic Ovary Syndrome - pathology; Signal Transduction - physiology; DNA methylation; PCOS; CREB; granulosa cells; iPSC