Nuclear angiotensin-(1-7) receptor is functionally coupled to the formation of nitric oxide

• Published in: American Journal of Physiology - Renal Physiology Vol. 299; no. 5; pp. F983 - F990
• Main Authors: Gwathmey, Tanya M, Westwood, Brian M, Pirro, Nancy T, Tang, Lijun, Rose, James C, Diz, Debra I, Chappell, Mark C
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.11.2010
• Subjects: ACE inhibitors; Angiotensin II - analogs & derivatives; Angiotensin II - metabolism; Angiotensin-Converting Enzyme Inhibitors - pharmacology; Animals; Blotting, Western; Cell Nucleus - metabolism; Cells; Enzyme Inhibitors - pharmacology; Female; Fluorescent Antibody Technique; Gene expression; Immunohistochemistry; Kidney - metabolism; Kidney Cortex - metabolism; Kidney Tubules, Proximal - metabolism; Kidneys; Male; NG-Nitroarginine Methyl Ester - pharmacology; Nitric oxide; Nitric Oxide - biosynthesis; Nitric Oxide - physiology; Nitric Oxide Synthase Type III - antagonists & inhibitors; Nitric Oxide Synthase Type III - biosynthesis; Peptide Hydrolases - metabolism; Peptidyl-Dipeptidase A - metabolism; Proteins; Proto-Oncogene Mas; Proto-Oncogene Proteins - metabolism; Radioligand Assay; Receptors, Angiotensin - metabolism; Receptors, G-Protein-Coupled - metabolism; Renin-Angiotensin System - physiology; Sheep; Studies; T cell receptors

The kidney is an important target for the actions of the renin-angiotensin system (RAS) and this tissue contains a complete local RAS that expresses the bioactive peptides angiotensin II (ANG II) and Ang-(1-7). We find both angiotensin type 1 (AT(1)R) and type 2 (AT(2)R) receptors expressed on renal...