Genetic analysis of pancreatic phospholipase A2 (PLA2G1B) in patients with chronic pancreatitis

• Published in: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] Vol. 22; no. 2; pp. 244 - 247
• Main Authors: Ewers, Maren, Epple, Denise, Bugert, Peter, Rosendahl, Jonas, Witt, Heiko
• Format: Journal Article
• Language: English
• Published: Switzerland Elsevier B.V 01.03.2022; Elsevier Limited
• Subjects: Age; Blood & organ donations; Chronic pancreatitis; Digestive enzyme; DNA sequencing; Enzymes; Exons; Gene Frequency; Genes; Genetic analysis; Genetic Testing; Genetics; Genotypes; Group IB Phospholipases A2 - genetics; Humans; Lipase; Mutation; Pancreas; Pancreatitis; Pancreatitis, Alcoholic - genetics; Pancreatitis, Chronic - genetics; Patients; Pediatrics; Phospholipase A2; PLA2G1B; Sequence Analysis, DNA; Japan; India; Genetics; NACP; PLA2G1B; CP; Chronic pancreatitis; Digestive enzyme

Genetic mutations in various pancreatic enzymes or their counteracting proteins have been linked to chronic pancreatitis. In particular, variants in the genes encoding pancreatic lipase (PNLIP) and carboxyl ester lipase (CEL) have been associated with pancreatitis. Therefore, we investigated pancrea...