Targeted siRNA delivery to lung epithelia reduces airway inflammation in a mouse model of allergic asthma

• Published in: Biotechnology and bioprocess engineering Vol. 29; no. 1; pp. 97 - 108
• Main Authors: Ullah, Irfan, Choi, Hyo Sung, Choi, Changseon, Chung, Kunho, Jung, Jae Wook, Yun, Gyeongju, Heo, Seoyoun, Yi, Yujong, Kang, Eunhwa, Kim, Sang-Heon, Yoon, Ho Joo, Rhim, Taiyoun, Lee, Sang-Kyung
• Format: Journal Article
• Language: English
• Published: Seoul The Korean Society for Biotechnology and Bioengineering 01.02.2024; Springer Nature B.V; 한국생물공학회
• Subjects: Allergic reactions; Allergies; Asthma; Biotechnology; Bronchoconstriction; Chemistry; Chemistry and Materials Science; cysteine; Epithelial cells; Epithelium; gene targeting; Glycoproteins; hypersecretion; Industrial and Production Engineering; Inflammation; Inflammatory diseases; Interleukin 13; Interleukin 4; Lungs; Lymphocytes T; Lyssavirus; mice; Mucus; Ovalbumin; Peptides; Rabies; Rabies lyssavirus; Receptors; Research Paper; Respiratory tract diseases; siRNA; therapeutics; 생물공학; siRNA delivery; Lung epithelial cells; Rabies virus glycoprotein; Airway inflammation; Interleukin-4 receptor alpha; Asthma

Asthma is a chronic inflammatory disease triggered by allergic reactions in the bronchia. These reactions lead to swelling of mucous membranes, hypersecretion of mucus, and bronchoconstriction, resulting in a restricted opening of the lung airway. Allergic pulmonary inflammation and airway hyperresp...