Rational ligand choice extends the SABRE substrate scope

• Published in: Chemical communications (Cambridge, England) Vol. 56; no. 65; pp. 9336 - 9339
• Main Authors: Colell, Johannes F. P, Logan, Angus W. J, Zhou, Zijian, Lindale, Jacob R, Laasner, Raul, Shchepin, Roman V, Chekmenev, Eduard Y, Blum, Volker, Warren, Warren S, Malcolmson, Steven J, Theis, Thomas
• Format: Journal Article
• Language: English
• Published: Cambridge Royal Society of Chemistry 21.08.2020
• Subjects: Caffeine; Catalysts; Chelation; Chemical synthesis; Ligands; Pyridines; Substrates

Here we report on chelating ligands for Signal Amplification By Reversible Exchange (SABRE) catalysts that permit hyperpolarisation on otherwise sterically hindered substrates. We demonstrate 1 H enhancements of ∼100-fold over 8.5 T thermal for 2-substituted pyridines, and smaller, yet significant e...