Changing epidemiology and etiology of upper and lower gastrointestinal bleeding
Upper gastrointestinal bleeding (UGIB) develops in the oesophagus, stomach or duodenum and has an incidence of 47/100,000. Lower GIB (LGIB) develops in the small bowel, colon or anorectum and has an incidence of 33/100,000. Where the incidence of UGIB has fallen, driven by helicobacter pylori eradic...
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| Published in | Baillière's best practice & research. Clinical gastroenterology Vol. 42-43; p. 101610 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier Ltd
01.10.2019
Elsevier Limited |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Upper gastrointestinal bleeding (UGIB) develops in the oesophagus, stomach or duodenum and has an incidence of 47/100,000. Lower GIB (LGIB) develops in the small bowel, colon or anorectum and has an incidence of 33/100,000. Where the incidence of UGIB has fallen, driven by helicobacter pylori eradication and the use of proton pump inhibitors, the incidence of LGIB may be increasing. Interventions such as early endoscopy, risk assessment and national guidelines have improved clinical outcomes but have had limited impact on the economic burden of GIB. Previously LGIB was thought to be less severe than UGIB, but contemporary data suggest that patients with LGIB tend to have a longer length of hospital stay and may be at higher risk of death or re-bleeding. |
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| AbstractList | Upper gastrointestinal bleeding (UGIB) develops in the oesophagus, stomach or duodenum and has an incidence of 47/100,000. Lower GIB (LGIB) develops in the small bowel, colon or anorectum and has an incidence of 33/100,000. Where the incidence of UGIB has fallen, driven by helicobacter pylori eradication and the use of proton pump inhibitors, the incidence of LGIB may be increasing. Interventions such as early endoscopy, risk assessment and national guidelines have improved clinical outcomes but have had limited impact on the economic burden of GIB. Previously LGIB was thought to be less severe than UGIB, but contemporary data suggest that patients with LGIB tend to have a longer length of hospital stay and may be at higher risk of death or re-bleeding. Upper gastrointestinal bleeding (UGIB) develops in the oesophagus, stomach or duodenum and has an incidence of 47/100,000. Lower GIB (LGIB) develops in the small bowel, colon or anorectum and has an incidence of 33/100,000. Where the incidence of UGIB has fallen, driven by helicobacter pylori eradication and the use of proton pump inhibitors, the incidence of LGIB may be increasing. Interventions such as early endoscopy, risk assessment and national guidelines have improved clinical outcomes but have had limited impact on the economic burden of GIB. Previously LGIB was thought to be less severe than UGIB, but contemporary data suggest that patients with LGIB tend to have a longer length of hospital stay and may be at higher risk of death or re-bleeding.Upper gastrointestinal bleeding (UGIB) develops in the oesophagus, stomach or duodenum and has an incidence of 47/100,000. Lower GIB (LGIB) develops in the small bowel, colon or anorectum and has an incidence of 33/100,000. Where the incidence of UGIB has fallen, driven by helicobacter pylori eradication and the use of proton pump inhibitors, the incidence of LGIB may be increasing. Interventions such as early endoscopy, risk assessment and national guidelines have improved clinical outcomes but have had limited impact on the economic burden of GIB. Previously LGIB was thought to be less severe than UGIB, but contemporary data suggest that patients with LGIB tend to have a longer length of hospital stay and may be at higher risk of death or re-bleeding. |
| ArticleNumber | 101610 |
| Author | Oakland, Kathryn |
| Author_xml | – sequence: 1 givenname: Kathryn orcidid: 0000-0003-0280-1138 surname: Oakland fullname: Oakland, Kathryn email: kathryn.oakland@hcahealthcare.co.uk organization: Digestive Diseases and Renal Department, HCA Healthcare UK, 242 Marylebone Road, London, NW16JL, United Kingdom |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31785737$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.cgh.2008.02.049 10.1016/j.cgh.2017.04.031 10.1046/j.1365-2036.2000.00723.x 10.1186/1471-230X-13-104 10.1111/j.1365-2036.2006.02918.x 10.1016/j.cgh.2015.03.030 10.1111/j.1572-0241.2003.07517.x 10.1016/j.gie.2014.09.027 10.1038/ajg.2012.168 10.1159/000308361 10.1007/s00198-014-2647-z 10.1371/journal.pone.0187033 10.1111/j.1365-2036.2007.03340.x 10.1016/j.gie.2013.08.001 10.1001/jama.2018.17242 10.1371/journal.pone.0165278 10.1055/s-0032-1309736 10.1097/MCG.0000000000000393 10.1097/01.mcg.0000248004.73075.ad 10.3748/wjg.v20.i32.11326 10.1016/j.gie.2008.10.051 10.1016/S2468-1253(17)30150-4 10.1016/j.cgh.2014.11.007 10.1016/j.gie.2007.09.024 10.1016/j.cgh.2014.07.023 10.1038/ajg.2009.164 10.3748/wjg.v20.i46.17568 10.1136/gut.2010.228437 10.1136/bmjopen-2014-007230 10.1053/j.gastro.2016.04.013 10.4321/S1130-01082008000400002 10.1016/j.gie.2013.09.004 10.1161/CIRCOUTCOMES.114.001177 10.1001/archinte.163.7.838 10.1097/MEG.0b013e32835948e3 10.3346/jkms.2016.31.10.1611 10.1016/j.jbspin.2009.11.008 10.1007/s10620-017-4882-6 10.1136/annrheumdis-2013-204155 10.1016/S0889-8553(05)70130-8 10.1097/MD.0000000000002022 10.1053/j.gastro.2011.06.075 10.1016/j.cgh.2014.06.021 10.1007/s00535-014-1028-x 10.1002/jhm.606 10.1007/s00535-010-0299-0 10.1186/s40064-016-3185-2 10.1111/jgh.12595 10.1053/j.gastro.2007.06.007 10.3748/wjg.v21.i38.10890 10.1038/ajg.2014.82 10.7326/0003-4819-152-6-201003160-00003 10.1002/jhm.2360 10.1016/j.cgh.2008.03.021 10.1016/S0016-5085(89)80056-3 10.1111/j.1365-2036.2010.04563.x 10.1053/j.gastro.2011.03.048 10.1080/09537100500237004 10.15403/jgld.2014.1121.232.iiv1 10.1053/j.gastro.2017.04.022 10.1124/jpet.300.3.754 10.1038/ajg.2012.467 10.1371/journal.pone.0166166 |
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| References | Visovan, Tantau, Ciobanu, Pascu, Tantau (bib59) 2014; 23 Lorenzo, Gallois, Lahmek, Lesgourgues, Champion, Charpignon (bib64) 2017; 5 Redondo-Cerezo, Gomez-Ruiz, Sanchez-Manjavacas, Vinuelas, Jimeno, Perez-Vigara (bib65) 2008; 100 Kwak, Cha, Han, Yoon, Jeon, Shin (bib67) 2016; 31 Abougergi, Travis, Saltzman (bib3) 2015; 81 Lanas, Boers, Nuevo (bib32) 2015; 74 Miller, Dorreen, Martel, Huynh, Barkun (bib51) 2017; 15 Ron-Tal Fisher, Gralnek, Eisen, Williams, Holub (bib66) 2014; 79 Anglin, Yuan, Moayyedi, Tse, Armstrong, Leontiadis (bib53) 2014; 109 Jiang, Chen, Hu, Yu, Yang, Deng (bib52) 2015; 13 Theocharis, Thomopoulos, Sakellaropoulos, Katsakoulis, Nikolopoulou (bib5) 2008; 42 Post, Kuipers, Meijer (bib6) 2006; 23 Whelan, Chen, Kaboli, Siddique, Prochaska, Meltzer (bib68) 2010; 5 Lim, Kwon, Kim, Kim, Kang, Park (bib27) 2013; 13 Kauffman (bib40) 1989; 96 Targownik, Nabalamba (bib62) 2006; 4 Liberopoulos, Elisaf, Tselepis, Archimandritis, Kiskinis, Cokkinos (bib46) 2006; 17 Melloni, Washam, Jones, Halim, Hasselblad, Mayer (bib47) 2015; 8 Lorenzo, Fernandez-de-Larrea, Michel, Romero, Lope, Bessa (bib24) 2018 Tanaka, Hase, Miyazawa, Takeuchi (bib29) 2002; 300 Lanas, Garcia-Rodriguez, Polo-Tomas, Ponce, Quintero, Perez-Aisa (bib7) 2011; 33 Bardou, Barkun (bib34) 2010; 77 Ahmed, Armstrong, Robertson, Morris, Blatchford, Stanley (bib10) 2015; 21 Ray, Murray, Griffin, Chung, Smalley, Hall (bib44) 2010; 152 Oakland, Desborough, Murphy, Schachter, Jairath (bib42) 2017 Hreinsson, Gumundsson, Kalaitzakis, Bjornsson (bib14) 2013; 25 Oakland, Isherwood, Lahiff, Goldsmith, Desborough, Colman (bib76) 2017; 5 Ray, Chung, Murray, Smalley, Daugherty, Dupont (bib48) 2018; 320 Mukherjee, Vishnubhatla, Amarapurkar, Das, Sood, Chawla (bib17) 2017; 12 Lanas, Garcia-Rodriguez, Polo-Tomas, Ponce, Alonso-Abreu, Perez-Aisa (bib2) 2009; 104 Cryer, Wilcox, Henk, Zlateva, Chen, Zarotsky (bib72) 2010; 13 Oakland, Guy, Uberoi, Hogg, Mortensen, Murphy (bib18) 2018; 67 Endo, Sakai, Kato, Umezawa, Higurashi, Ohkubo (bib41) 2015; 50 Longstreth (bib15) 1997; 92 Strate, Singh, Boylan, Piawah, Cao, Chan (bib33) 2016; 11 Newman, Fitzgerald, Gupta, von Roon, Sigurdsson, Allen-Mersh (bib19) 2012; 14 Jiang, Liu, Mao, Zhang, Zhang, Xu (bib26) 2016; 5 Loperfido, Baldo, Piovesana, Bellina, Rossi, Groppo (bib4) 2009; 70 Manuel, Cutler, Goldstein, Fennerty, Brown (bib28) 2007; 25 Lim, Desarno, Lidofsky, Ganguly (bib11) 2014; 20 Strate, Ayanian, Kotler, Syngal (bib20) 2008; 6 Tsai, Wen, Huang, Chen, Kuo, Hsiao (bib45) 2011; 46 Cea Soriano, Lanas, Soriano-Gabarro, Garcia Rodriguez (bib38) 2018 Oakland, Jairath, Uberoi, Guy, Ayaru, Mortensen (bib74) 2017; 2 Laine, Yang, Chang, Datto (bib58) 2012; 107 Peng, Hu, Luo, Hou, Lin, Lee (bib55) 2014; 25 Adam, Barkun (bib70) 2008; 11 Laursen, Dalton, Murray, Michell, Johnston, Schultz (bib75) 2015; 13 Quan, Frolkis, Milne, Molodecky, Yang, Dixon (bib9) 2014; 20 Fujimori, Takahashi, Seo, Gudis, Ehara, Kobayashi (bib35) 2010; 82 Strate, Orav, Syngal (bib21) 2003; 163 Cheng, Hu, Lin, Luo, Peng, Hou (bib54) 2015; 94 Navaneethan, Njei, Venkatesh, Sanaka (bib71) 2014; 79 Washio, Esaki, Maehata, Miyazaki, Kobayashi, Ishikawa (bib36) 2016; 14 van Leerdam, Vreeburg, Rauws, Geraedts, Tijssen, Reitsma (bib61) 2003; 98 Cryer, Li, Simon, Singh, Stillman, Berger, GI-REASONS (bib31) 2013; 108 Raju, Gerson, Das, Lewis (bib1) 2007; 133 Chan, Leung, Wong, Ching, Tse, Au (bib43) 2016; 151 Nagata, Niikura, Aoki, Shimbo, Kishida, Sekine (bib22) 2014; 29 Everhart (bib25) 2000; 29 Hreinsson, Palsdottir, Bjornsson (bib49) 2016; 50 Brenner, Schrotz-King, Holleczek, Katalinic, Hoffmeister (bib60) 2016; 113 Wallace, Syer, Denou, de Palma, Vong, McKnight (bib37) 2011; 141 Hearnshaw, Logan, Lowe, Travis, Murphy, Palmer (bib16) 2011; 60 Pant, Desai, Deshpande, Taylor, Olyaee, Gilroy (bib13) 2015; 10 Jairath, Kahan, Logan, Hearnshaw, Dore, Travis (bib73) 2012; 44 Lanas, Carrera-Lasfuentes, Arguedas, Garcia, Bujanda, Calvet (bib50) 2015; 13 Crooks, Card, West (bib63) 2011; 141 Enestvedt, Gralnek, Mattek, Lieberman, Eisen (bib56) 2008; 67 Campbell, Stokes, Bargo, Logan, Mora, Hodge (bib69) 2015; 5 Wuerth, Rockey (bib8) 2018; 63 Somasundaram, Sigthorsson, Simpson, Watts, Jacob, Tavares (bib30) 2000; 14 Elwood, Morgan, Galante, Chia, Dolwani, Graziano (bib39) 2016; 11 Wheat, Strate (bib57) 2016; 14 Jamal, Samarasena, Hashemzadeh, Vega (bib12) 2008; 6 Hooi, Lai, Ng, Suen, Underwood, Tanyingoh (bib23) 2017; 153 Hooi (10.1016/j.bpg.2019.04.003_bib23) 2017; 153 Mukherjee (10.1016/j.bpg.2019.04.003_bib17) 2017; 12 Manuel (10.1016/j.bpg.2019.04.003_bib28) 2007; 25 Quan (10.1016/j.bpg.2019.04.003_bib9) 2014; 20 Kauffman (10.1016/j.bpg.2019.04.003_bib40) 1989; 96 Somasundaram (10.1016/j.bpg.2019.04.003_bib30) 2000; 14 Strate (10.1016/j.bpg.2019.04.003_bib33) 2016; 11 Chan (10.1016/j.bpg.2019.04.003_bib43) 2016; 151 Ahmed (10.1016/j.bpg.2019.04.003_bib10) 2015; 21 Strate (10.1016/j.bpg.2019.04.003_bib20) 2008; 6 Liberopoulos (10.1016/j.bpg.2019.04.003_bib46) 2006; 17 Adam (10.1016/j.bpg.2019.04.003_bib70) 2008; 11 Lanas (10.1016/j.bpg.2019.04.003_bib7) 2011; 33 Nagata (10.1016/j.bpg.2019.04.003_bib22) 2014; 29 Cryer (10.1016/j.bpg.2019.04.003_bib72) 2010; 13 Jamal (10.1016/j.bpg.2019.04.003_bib12) 2008; 6 Loperfido (10.1016/j.bpg.2019.04.003_bib4) 2009; 70 Navaneethan (10.1016/j.bpg.2019.04.003_bib71) 2014; 79 Lorenzo (10.1016/j.bpg.2019.04.003_bib64) 2017; 5 Lanas (10.1016/j.bpg.2019.04.003_bib50) 2015; 13 Laursen (10.1016/j.bpg.2019.04.003_bib75) 2015; 13 Lorenzo (10.1016/j.bpg.2019.04.003_bib24) 2018 Abougergi (10.1016/j.bpg.2019.04.003_bib3) 2015; 81 Hearnshaw (10.1016/j.bpg.2019.04.003_bib16) 2011; 60 Cheng (10.1016/j.bpg.2019.04.003_bib54) 2015; 94 Enestvedt (10.1016/j.bpg.2019.04.003_bib56) 2008; 67 Lanas (10.1016/j.bpg.2019.04.003_bib2) 2009; 104 Jiang (10.1016/j.bpg.2019.04.003_bib26) 2016; 5 Newman (10.1016/j.bpg.2019.04.003_bib19) 2012; 14 Brenner (10.1016/j.bpg.2019.04.003_bib60) 2016; 113 Theocharis (10.1016/j.bpg.2019.04.003_bib5) 2008; 42 Campbell (10.1016/j.bpg.2019.04.003_bib69) 2015; 5 Anglin (10.1016/j.bpg.2019.04.003_bib53) 2014; 109 Wallace (10.1016/j.bpg.2019.04.003_bib37) 2011; 141 Melloni (10.1016/j.bpg.2019.04.003_bib47) 2015; 8 Targownik (10.1016/j.bpg.2019.04.003_bib62) 2006; 4 Cea Soriano (10.1016/j.bpg.2019.04.003_bib38) 2018 Crooks (10.1016/j.bpg.2019.04.003_bib63) 2011; 141 Bardou (10.1016/j.bpg.2019.04.003_bib34) 2010; 77 Peng (10.1016/j.bpg.2019.04.003_bib55) 2014; 25 van Leerdam (10.1016/j.bpg.2019.04.003_bib61) 2003; 98 Raju (10.1016/j.bpg.2019.04.003_bib1) 2007; 133 Jairath (10.1016/j.bpg.2019.04.003_bib73) 2012; 44 Oakland (10.1016/j.bpg.2019.04.003_bib76) 2017; 5 Elwood (10.1016/j.bpg.2019.04.003_bib39) 2016; 11 Wuerth (10.1016/j.bpg.2019.04.003_bib8) 2018; 63 Tsai (10.1016/j.bpg.2019.04.003_bib45) 2011; 46 Tanaka (10.1016/j.bpg.2019.04.003_bib29) 2002; 300 Lim (10.1016/j.bpg.2019.04.003_bib27) 2013; 13 Laine (10.1016/j.bpg.2019.04.003_bib58) 2012; 107 Whelan (10.1016/j.bpg.2019.04.003_bib68) 2010; 5 Redondo-Cerezo (10.1016/j.bpg.2019.04.003_bib65) 2008; 100 Miller (10.1016/j.bpg.2019.04.003_bib51) 2017; 15 Longstreth (10.1016/j.bpg.2019.04.003_bib15) 1997; 92 Pant (10.1016/j.bpg.2019.04.003_bib13) 2015; 10 Oakland (10.1016/j.bpg.2019.04.003_bib42) 2017 Wheat (10.1016/j.bpg.2019.04.003_bib57) 2016; 14 Strate (10.1016/j.bpg.2019.04.003_bib21) 2003; 163 Everhart (10.1016/j.bpg.2019.04.003_bib25) 2000; 29 Lim (10.1016/j.bpg.2019.04.003_bib11) 2014; 20 Visovan (10.1016/j.bpg.2019.04.003_bib59) 2014; 23 Cryer (10.1016/j.bpg.2019.04.003_bib31) 2013; 108 Endo (10.1016/j.bpg.2019.04.003_bib41) 2015; 50 Post (10.1016/j.bpg.2019.04.003_bib6) 2006; 23 Fujimori (10.1016/j.bpg.2019.04.003_bib35) 2010; 82 Oakland (10.1016/j.bpg.2019.04.003_bib74) 2017; 2 Hreinsson (10.1016/j.bpg.2019.04.003_bib49) 2016; 50 Washio (10.1016/j.bpg.2019.04.003_bib36) 2016; 14 Jiang (10.1016/j.bpg.2019.04.003_bib52) 2015; 13 Ray (10.1016/j.bpg.2019.04.003_bib48) 2018; 320 Ron-Tal Fisher (10.1016/j.bpg.2019.04.003_bib66) 2014; 79 Lanas (10.1016/j.bpg.2019.04.003_bib32) 2015; 74 Hreinsson (10.1016/j.bpg.2019.04.003_bib14) 2013; 25 Oakland (10.1016/j.bpg.2019.04.003_bib18) 2018; 67 Ray (10.1016/j.bpg.2019.04.003_bib44) 2010; 152 Kwak (10.1016/j.bpg.2019.04.003_bib67) 2016; 31 |
| References_xml | – volume: 113 start-page: 101 year: 2016 end-page: 106 ident: bib60 article-title: Declining bowel cancer incidence and mortality in Germany publication-title: Deutsches Arzteblatt international – volume: 29 start-page: 559 year: 2000 end-page: 578 ident: bib25 article-title: Recent developments in the epidemiology of Helicobacter pylori publication-title: Gastroenterol Clin N Am – volume: 94 year: 2015 ident: bib54 article-title: Use of SSRI, but not SNRI, increased upper and lower gastrointestinal bleeding: a nationwide population-based cohort study in Taiwan publication-title: Medicine – volume: 152 start-page: 337 year: 2010 end-page: 345 ident: bib44 article-title: Outcomes with concurrent use of clopidogrel and proton-pump inhibitors: a cohort study publication-title: Ann Intern Med – volume: 13 year: 2015 ident: bib52 article-title: Use of selective serotonin reuptake inhibitors and risk of upper gastrointestinal bleeding: a systematic review and meta-analysis publication-title: Clin Gastroenterol Hepatol : Off Clin Pract J Am Gastroenterol Assoc – volume: 60 start-page: 1327 year: 2011 end-page: 1335 ident: bib16 article-title: Acute upper gastrointestinal bleeding in the UK: patient characteristics, diagnoses and outcomes in the 2007 UK audit publication-title: Gut – volume: 21 start-page: 10890 year: 2015 end-page: 10897 ident: bib10 article-title: Upper gastrointestinal bleeding in Scotland 2000-2010: improved outcomes but a significant weekend effect publication-title: World J Gastroenterol – volume: 14 start-page: 1020 year: 2012 end-page: 1026 ident: bib19 article-title: Outcome predictors in acute surgical admissions for lower gastrointestinal bleeding. Colorectal disease publication-title: Off. J. Assoc. Coloproctol. G. B. Irel. – volume: 13 year: 2015 ident: bib75 article-title: Performance of new thresholds of the Glasgow Blatchford score in managing patients with upper gastrointestinal bleeding publication-title: Clin Gastroenterol Hepatol : Off. Clin. Pract. J. Am. Gastroenterol. Assoc. – volume: 151 start-page: 271 year: 2016 end-page: 277 ident: bib43 article-title: Risks of bleeding recurrence and cardiovascular events with continued aspirin use after lower gastrointestinal hemorrhage publication-title: Gastroenterology – volume: 109 start-page: 811 year: 2014 end-page: 819 ident: bib53 article-title: Risk of upper gastrointestinal bleeding with selective serotonin reuptake inhibitors with or without concurrent nonsteroidal anti-inflammatory use: a systematic review and meta-analysis publication-title: Am J Gastroenterol – volume: 20 start-page: 11326 year: 2014 end-page: 11332 ident: bib11 article-title: Hospitalization for variceal hemorrhage in an era with more prevalent cirrhosis publication-title: World J Gastroenterol – volume: 17 start-page: 1 year: 2006 end-page: 6 ident: bib46 article-title: Upper gastrointestinal haemorrhage complicating antiplatelet treatment with aspirin and/or clopidogrel: where we are now? publication-title: Platelets – volume: 11 year: 2016 ident: bib33 article-title: A prospective study of alcohol consumption and smoking and the risk of major gastrointestinal bleeding in men publication-title: PLoS One – volume: 46 start-page: 39 year: 2011 end-page: 45 ident: bib45 article-title: Cardiovascular and gastrointestinal events of three antiplatelet therapies: clopidogrel, clopidogrel plus proton-pump inhibitors, and aspirin plus proton-pump inhibitors in patients with previous gastrointestinal bleeding publication-title: J Gastroenterol – volume: 153 start-page: 420 year: 2017 end-page: 429 ident: bib23 article-title: Global prevalence of Helicobacter pylori infection: systematic review and meta-analysis publication-title: Gastroenterology – volume: 5 year: 2015 ident: bib69 article-title: Costs and quality of life associated with acute upper gastrointestinal bleeding in the UK: cohort analysis of patients in a cluster randomised trial publication-title: BMJ open – volume: 163 start-page: 838 year: 2003 end-page: 843 ident: bib21 article-title: Early predictors of severity in acute lower intestinal tract bleeding publication-title: Arch Intern Med – volume: 100 start-page: 202 year: 2008 end-page: 207 ident: bib65 article-title: Long-term follow-up of patients with small-bowel angiodysplasia on capsule endoscopy. Determinants of a higher clinical impact and rebleeding rate publication-title: Rev Esp Enferm Dig : Organo Of de la Soc Esp de Patol Dig – volume: 79 start-page: 317 year: 2014 end-page: 325 ident: bib66 article-title: Endoscopic hemostasis is rarely used for hematochezia: a population-based study from the clinical outcomes research initiative national endoscopic database publication-title: Gastrointest Endosc – volume: 25 start-page: 1423 year: 2007 end-page: 1427 ident: bib28 article-title: Decreasing prevalence combined with increasing eradication of Helicobacter pylori infection in the United States has not resulted in fewer hospital admissions for peptic ulcer disease-related complications publication-title: Aliment Pharmacol Ther – volume: 67 start-page: 422 year: 2008 end-page: 429 ident: bib56 article-title: An evaluation of endoscopic indications and findings related to nonvariceal upper-GI hemorrhage in a large multicenter consortium publication-title: Gastrointest Endosc – volume: 25 start-page: 1617 year: 2014 end-page: 1623 ident: bib55 article-title: Alendronate, a bisphosphonate, increased upper and lower gastrointestinal bleeding: risk factor analysis from a nationwide population-based study publication-title: Osteoporos Int : J Estable Result Coop Between Eur Found Osteoporos Nat Osteoporos Found USA – volume: 5 start-page: 119 year: 2017 end-page: 127 ident: bib64 article-title: Middle-term mortality and re-bleeding after initial diverticular bleeding: a nationwide study of 365 mostly elderly French patients publication-title: U Eur Gastroenterol J – volume: 141 start-page: 1314 year: 2011 end-page: 1322 ident: bib37 article-title: Proton pump inhibitors exacerbate NSAID-induced small intestinal injury by inducing dysbiosis publication-title: Gastroenterology – volume: 63 start-page: 1286 year: 2018 end-page: 1293 ident: bib8 article-title: Changing epidemiology of upper gastrointestinal hemorrhage in the last decade: a nationwide analysis publication-title: Dig Dis Sci – year: 2017 ident: bib42 article-title: Re-bleeding and mortality after lower gastrointestinal bleeding in patients taking anti-platelets or anti-coagulants publication-title: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association – volume: 6 start-page: 689 year: 2008 end-page: 695 ident: bib12 article-title: Declining hospitalization rate of esophageal variceal bleeding in the United States publication-title: Clin Gastroenterol Hepatol : Off Clin Pract J Am Gastroenterol Assoc – volume: 42 start-page: 128 year: 2008 end-page: 133 ident: bib5 article-title: Changing trends in the epidemiology and clinical outcome of acute upper gastrointestinal bleeding in a defined geographical area in Greece publication-title: J Clin Gastroenterol – volume: 320 start-page: 2221 year: 2018 end-page: 2230 ident: bib48 article-title: Association of oral anticoagulants and proton pump inhibitor cotherapy with hospitalization for upper gastrointestinal tract bleeding publication-title: Jama – volume: 82 start-page: 167 year: 2010 end-page: 172 ident: bib35 article-title: Prevention of traditional NSAID-induced small intestinal injury: recent preliminary studies using capsule endoscopy publication-title: Digestion – volume: 11 start-page: 1 year: 2008 end-page: 3 ident: bib70 article-title: Estimates of costs of hospital stay for variceal and nonvariceal upper gastrointestinal bleeding in the United States. Value in health publication-title: J Int Soc Pharmacoecon Outcomes Res – volume: 15 year: 2017 ident: bib51 article-title: Risk of gastrointestinal bleeding in patients taking non-vitamin K antagonist oral anticoagulants: a systematic review and meta-analysis publication-title: Clin Gastroenterol Hepatol : Off Clin Pract J Am Gastroenterol Assoc – volume: 98 start-page: 1494 year: 2003 end-page: 1499 ident: bib61 article-title: Acute upper GI bleeding: did anything change? Time trend analysis of incidence and outcome of acute upper GI bleeding between 1993/1994 and 2000 publication-title: Am J Gastroenterol – year: 2018 ident: bib24 article-title: Helicobacter pylori seroprevalence in Spain: influence of adult and childhood sociodemographic factors publication-title: Eur J Cancer Prev : Off J Eur Cancer Prev Organ (ECP) – volume: 79 year: 2014 ident: bib71 article-title: Timing of colonoscopy and outcomes in patients with lower GI bleeding: a nationwide population-based study publication-title: Gastrointest Endosc – volume: 44 start-page: 723 year: 2012 end-page: 730 ident: bib73 article-title: Outcomes following acute nonvariceal upper gastrointestinal bleeding in relation to time to endoscopy: results from a nationwide study publication-title: Endoscopy – volume: 70 start-page: 212 year: 2009 end-page: 224 ident: bib4 article-title: Changing trends in acute upper-GI bleeding: a population-based study publication-title: Gastrointest Endosc – volume: 14 start-page: 639 year: 2000 end-page: 650 ident: bib30 article-title: Uncoupling of intestinal mitochondrial oxidative phosphorylation and inhibition of cyclooxygenase are required for the development of NSAID-enteropathy in the rat publication-title: Aliment Pharmacol Ther – volume: 5 year: 2017 ident: bib76 article-title: Diagnostic and therapeutic treatment modalities for acute lower gastrointestinal bleeding: a systematic review publication-title: Endosc Int Open – volume: 11 year: 2016 ident: bib39 article-title: Systematic review and meta-analysis of randomised trials to ascertain fatal gastrointestinal bleeding events attributable to preventive low-dose aspirin: No evidence of increased risk publication-title: PLoS One – volume: 5 start-page: 141 year: 2010 end-page: 147 ident: bib68 article-title: Upper versus lower gastrointestinal bleeding: a direct comparison of clinical presentation, outcomes, and resource utilization publication-title: J Hosp Med – volume: 108 start-page: 392 year: 2013 end-page: 400 ident: bib31 article-title: A novel 6-month, prospective, randomized, open-label, blinded endpoint (PROBE) trial publication-title: Am J Gastroenterol – volume: 96 start-page: 606 year: 1989 end-page: 614 ident: bib40 article-title: Aspirin-induced gastric mucosal injury: lessons learned from animal models publication-title: Gastroenterology – volume: 8 start-page: 47 year: 2015 end-page: 55 ident: bib47 article-title: Conflicting results between randomized trials and observational studies on the impact of proton pump inhibitors on cardiovascular events when coadministered with dual antiplatelet therapy: systematic review publication-title: Circ. Cardiovasc. Qual. Outcomes – volume: 77 start-page: 6 year: 2010 end-page: 12 ident: bib34 article-title: Preventing the gastrointestinal adverse effects of nonsteroidal anti-inflammatory drugs: from risk factor identification to risk factor intervention publication-title: Joint Bone Spine : Rev. Rhum. – volume: 14 year: 2016 ident: bib36 article-title: Proton pump inhibitors increase incidence of nonsteroidal anti-inflammatory drug-induced small bowel injury: a randomized, placebo-controlled trial. Clinical gastroenterology and hepatology : the official clinical practice publication-title: J Am Gastroenterol Assoc – volume: 33 start-page: 585 year: 2011 end-page: 591 ident: bib7 article-title: The changing face of hospitalisation due to gastrointestinal bleeding and perforation publication-title: Aliment Pharmacol Ther – volume: 50 start-page: 378 year: 2015 end-page: 386 ident: bib41 article-title: Small bowel injury in low-dose aspirin users publication-title: J Gastroenterol – volume: 133 start-page: 1697 year: 2007 end-page: 1717 ident: bib1 article-title: American Gastroenterological Association (AGA) Institute technical review on obscure gastrointestinal bleeding publication-title: Gastroenterology – volume: 20 start-page: 17568 year: 2014 end-page: 17577 ident: bib9 article-title: Upper-gastrointestinal bleeding secondary to peptic ulcer disease: incidence and outcomes publication-title: World J Gastroenterol – volume: 104 start-page: 1633 year: 2009 end-page: 1641 ident: bib2 article-title: Time trends and impact of upper and lower gastrointestinal bleeding and perforation in clinical practice publication-title: Am J Gastroenterol – volume: 6 start-page: 1004 year: 2008 end-page: 1010 ident: bib20 article-title: Risk factors for mortality in lower intestinal bleeding publication-title: Clin Gastroenterol Hepatol : Off Clin Pract J Am Gastroenterol Assoc – volume: 2 start-page: 635 year: 2017 end-page: 643 ident: bib74 article-title: Derivation and validation of a novel risk score for safe discharge after acute lower gastrointestinal bleeding: a modelling study publication-title: Lancet Gastroenterol Hepatology – volume: 10 start-page: 453 year: 2015 end-page: 456 ident: bib13 article-title: Esophageal variceal bleeding in hospitalized patients with cirrhosis publication-title: J Hosp Med – volume: 31 start-page: 1611 year: 2016 end-page: 1616 ident: bib67 article-title: The clinical outcomes of lower gastrointestinal bleeding are not better than those of upper gastrointestinal bleeding publication-title: J Korean Med Sci – volume: 92 start-page: 419 year: 1997 end-page: 424 ident: bib15 article-title: Epidemiology and outcome of patients hospitalized with acute lower gastrointestinal hemorrhage: a population-based study publication-title: Am J Gastroenterol – volume: 81 start-page: 882 year: 2015 end-page: 888 ident: bib3 article-title: The in-hospital mortality rate for upper GI hemorrhage has decreased over 2 decades in the United States: a nationwide analysis publication-title: Gastrointest Endosc – volume: 14 year: 2016 ident: bib57 article-title: Trends in hospitalization for diverticulitis and diverticular bleeding in the United States from 2000 to 2010 publication-title: Clin Gastroenterol Hepatol : Off Clin Pract J Am Gastroenterol Assoc – volume: 13 start-page: 70 year: 2010 end-page: 77 ident: bib72 article-title: The economics of upper gastrointestinal bleeding in a US managed-care setting: a retrospective, claims-based analysis publication-title: J Med Econ – volume: 25 start-page: 37 year: 2013 end-page: 43 ident: bib14 article-title: Lower gastrointestinal bleeding: incidence, etiology, and outcomes in a population-based setting publication-title: Eur J Gastroenterol Hepatol – volume: 13 start-page: 104 year: 2013 ident: bib27 article-title: Prevalence and risk factors of Helicobacter pylori infection in Korea: nationwide multicenter study over 13 years publication-title: BMC Gastroenterol – volume: 23 start-page: 1587 year: 2006 end-page: 1593 ident: bib6 article-title: Declining incidence of peptic ulcer but not of its complications: a nation-wide study in The Netherlands publication-title: Aliment Pharmacol Ther – volume: 13 year: 2015 ident: bib50 article-title: Risk of upper and lower gastrointestinal bleeding in patients taking nonsteroidal anti-inflammatory drugs, antiplatelet agents, or anticoagulants publication-title: Clin Gastroenterol Hepatol : Off Clin Pract J Am Gastroenterol Assoc – volume: 4 start-page: 1459 year: 2006 end-page: 1466 ident: bib62 article-title: Trends in management and outcomes of acute nonvariceal upper gastrointestinal bleeding: 1993-2003. Clinical gastroenterology and hepatology : the official clinical practice publication-title: J Am Gastroenterol Assoc – volume: 300 start-page: 754 year: 2002 end-page: 761 ident: bib29 article-title: Up-regulation of cyclooxygenase-2 by inhibition of cyclooxygenase-1: a key to nonsteroidal anti-inflammatory drug-induced intestinal damage publication-title: J Pharmacol Exp Ther – volume: 67 start-page: 654 year: 2018 end-page: 662 ident: bib18 article-title: Acute lower GI bleeding in the UK: patient characteristics, interventions and outcomes in the first nationwide audit publication-title: Gut – volume: 23 start-page: 147 year: 2014 end-page: 151 ident: bib59 article-title: Increasing prevalence of right-sided colonic adenomas in a high-volume endoscopy department in Romania: implications for colorectal cancer screening publication-title: J Gastrointest Liver Dis : JGLD – volume: 5 start-page: 1601 year: 2016 ident: bib26 article-title: Downward trend in the prevalence of Helicobacter pylori infections and corresponding frequent upper gastrointestinal diseases profile changes in Southeastern China between 2003 and 2012 publication-title: SpringerPlus – volume: 12 year: 2017 ident: bib17 article-title: Etiology and mode of presentation of chronic liver diseases in India: a multi centric study publication-title: PLoS One – year: 2018 ident: bib38 article-title: Incidence of upper and lower gastrointestinal bleeding in new users of low-dose aspirin publication-title: Clin Gastroenterol Hepatol : Off Clin Pract J Am Gastroenterol Assoc – volume: 50 start-page: 408 year: 2016 end-page: 413 ident: bib49 article-title: The association of drugs with severity and specific causes of acute lower gastrointestinal bleeding: a prospective study publication-title: J Clin Gastroenterol – volume: 107 start-page: 1190 year: 2012 end-page: 1195 ident: bib58 article-title: Trends for incidence of hospitalization and death due to GI complications in the United States from 2001 to 2009 publication-title: Am J Gastroenterol – volume: 141 start-page: 62 year: 2011 end-page: 70 ident: bib63 article-title: Reductions in 28-day mortality following hospital admission for upper gastrointestinal hemorrhage publication-title: Gastroenterology – volume: 29 start-page: 1786 year: 2014 end-page: 1793 ident: bib22 article-title: Colonic diverticular hemorrhage associated with the use of nonsteroidal anti-inflammatory drugs, low-dose aspirin, antiplatelet drugs, and dual therapy publication-title: J Gastroenterol Hepatol – volume: 74 start-page: 675 year: 2015 end-page: 681 ident: bib32 article-title: Gastrointestinal events in at-risk patients starting non-steroidal anti-inflammatory drugs (NSAIDs) for rheumatic diseases: the EVIDENCE study of European routine practice publication-title: Ann Rheum Dis – volume: 6 start-page: 689 year: 2008 ident: 10.1016/j.bpg.2019.04.003_bib12 article-title: Declining hospitalization rate of esophageal variceal bleeding in the United States publication-title: Clin Gastroenterol Hepatol : Off Clin Pract J Am Gastroenterol Assoc doi: 10.1016/j.cgh.2008.02.049 – volume: 15 year: 2017 ident: 10.1016/j.bpg.2019.04.003_bib51 article-title: Risk of gastrointestinal bleeding in patients taking non-vitamin K antagonist oral anticoagulants: a systematic review and meta-analysis publication-title: Clin Gastroenterol Hepatol : Off Clin Pract J Am Gastroenterol Assoc doi: 10.1016/j.cgh.2017.04.031 – volume: 14 start-page: 639 year: 2000 ident: 10.1016/j.bpg.2019.04.003_bib30 article-title: Uncoupling of intestinal mitochondrial oxidative phosphorylation and inhibition of cyclooxygenase are required for the development of NSAID-enteropathy in the rat publication-title: Aliment Pharmacol Ther doi: 10.1046/j.1365-2036.2000.00723.x – year: 2018 ident: 10.1016/j.bpg.2019.04.003_bib38 article-title: Incidence of upper and lower gastrointestinal bleeding in new users of low-dose aspirin publication-title: Clin Gastroenterol Hepatol : Off Clin Pract J Am Gastroenterol Assoc – volume: 13 start-page: 104 year: 2013 ident: 10.1016/j.bpg.2019.04.003_bib27 article-title: Prevalence and risk factors of Helicobacter pylori infection in Korea: nationwide multicenter study over 13 years publication-title: BMC Gastroenterol doi: 10.1186/1471-230X-13-104 – volume: 23 start-page: 1587 year: 2006 ident: 10.1016/j.bpg.2019.04.003_bib6 article-title: Declining incidence of peptic ulcer but not of its complications: a nation-wide study in The Netherlands publication-title: Aliment Pharmacol Ther doi: 10.1111/j.1365-2036.2006.02918.x – volume: 14 year: 2016 ident: 10.1016/j.bpg.2019.04.003_bib57 article-title: Trends in hospitalization for diverticulitis and diverticular bleeding in the United States from 2000 to 2010 publication-title: Clin Gastroenterol Hepatol : Off Clin Pract J Am Gastroenterol Assoc doi: 10.1016/j.cgh.2015.03.030 – volume: 98 start-page: 1494 year: 2003 ident: 10.1016/j.bpg.2019.04.003_bib61 article-title: Acute upper GI bleeding: did anything change? Time trend analysis of incidence and outcome of acute upper GI bleeding between 1993/1994 and 2000 publication-title: Am J Gastroenterol doi: 10.1111/j.1572-0241.2003.07517.x – volume: 81 start-page: 882 year: 2015 ident: 10.1016/j.bpg.2019.04.003_bib3 article-title: The in-hospital mortality rate for upper GI hemorrhage has decreased over 2 decades in the United States: a nationwide analysis publication-title: Gastrointest Endosc doi: 10.1016/j.gie.2014.09.027 – volume: 107 start-page: 1190 year: 2012 ident: 10.1016/j.bpg.2019.04.003_bib58 article-title: Trends for incidence of hospitalization and death due to GI complications in the United States from 2001 to 2009 publication-title: Am J Gastroenterol doi: 10.1038/ajg.2012.168 – volume: 82 start-page: 167 year: 2010 ident: 10.1016/j.bpg.2019.04.003_bib35 article-title: Prevention of traditional NSAID-induced small intestinal injury: recent preliminary studies using capsule endoscopy publication-title: Digestion doi: 10.1159/000308361 – volume: 25 start-page: 1617 year: 2014 ident: 10.1016/j.bpg.2019.04.003_bib55 article-title: Alendronate, a bisphosphonate, increased upper and lower gastrointestinal bleeding: risk factor analysis from a nationwide population-based study publication-title: Osteoporos Int : J Estable Result Coop Between Eur Found Osteoporos Nat Osteoporos Found USA doi: 10.1007/s00198-014-2647-z – volume: 12 year: 2017 ident: 10.1016/j.bpg.2019.04.003_bib17 article-title: Etiology and mode of presentation of chronic liver diseases in India: a multi centric study publication-title: PLoS One doi: 10.1371/journal.pone.0187033 – volume: 25 start-page: 1423 year: 2007 ident: 10.1016/j.bpg.2019.04.003_bib28 article-title: Decreasing prevalence combined with increasing eradication of Helicobacter pylori infection in the United States has not resulted in fewer hospital admissions for peptic ulcer disease-related complications publication-title: Aliment Pharmacol Ther doi: 10.1111/j.1365-2036.2007.03340.x – volume: 79 year: 2014 ident: 10.1016/j.bpg.2019.04.003_bib71 article-title: Timing of colonoscopy and outcomes in patients with lower GI bleeding: a nationwide population-based study publication-title: Gastrointest Endosc doi: 10.1016/j.gie.2013.08.001 – volume: 320 start-page: 2221 year: 2018 ident: 10.1016/j.bpg.2019.04.003_bib48 article-title: Association of oral anticoagulants and proton pump inhibitor cotherapy with hospitalization for upper gastrointestinal tract bleeding publication-title: Jama doi: 10.1001/jama.2018.17242 – volume: 14 start-page: 1020 year: 2012 ident: 10.1016/j.bpg.2019.04.003_bib19 article-title: Outcome predictors in acute surgical admissions for lower gastrointestinal bleeding. Colorectal disease publication-title: Off. J. Assoc. Coloproctol. G. B. Irel. – volume: 11 year: 2016 ident: 10.1016/j.bpg.2019.04.003_bib33 article-title: A prospective study of alcohol consumption and smoking and the risk of major gastrointestinal bleeding in men publication-title: PLoS One doi: 10.1371/journal.pone.0165278 – volume: 44 start-page: 723 year: 2012 ident: 10.1016/j.bpg.2019.04.003_bib73 article-title: Outcomes following acute nonvariceal upper gastrointestinal bleeding in relation to time to endoscopy: results from a nationwide study publication-title: Endoscopy doi: 10.1055/s-0032-1309736 – volume: 50 start-page: 408 year: 2016 ident: 10.1016/j.bpg.2019.04.003_bib49 article-title: The association of drugs with severity and specific causes of acute lower gastrointestinal bleeding: a prospective study publication-title: J Clin Gastroenterol doi: 10.1097/MCG.0000000000000393 – volume: 5 start-page: 119 year: 2017 ident: 10.1016/j.bpg.2019.04.003_bib64 article-title: Middle-term mortality and re-bleeding after initial diverticular bleeding: a nationwide study of 365 mostly elderly French patients publication-title: U Eur Gastroenterol J – volume: 42 start-page: 128 year: 2008 ident: 10.1016/j.bpg.2019.04.003_bib5 article-title: Changing trends in the epidemiology and clinical outcome of acute upper gastrointestinal bleeding in a defined geographical area in Greece publication-title: J Clin Gastroenterol doi: 10.1097/01.mcg.0000248004.73075.ad – volume: 20 start-page: 11326 year: 2014 ident: 10.1016/j.bpg.2019.04.003_bib11 article-title: Hospitalization for variceal hemorrhage in an era with more prevalent cirrhosis publication-title: World J Gastroenterol doi: 10.3748/wjg.v20.i32.11326 – volume: 70 start-page: 212 year: 2009 ident: 10.1016/j.bpg.2019.04.003_bib4 article-title: Changing trends in acute upper-GI bleeding: a population-based study publication-title: Gastrointest Endosc doi: 10.1016/j.gie.2008.10.051 – volume: 92 start-page: 419 year: 1997 ident: 10.1016/j.bpg.2019.04.003_bib15 article-title: Epidemiology and outcome of patients hospitalized with acute lower gastrointestinal hemorrhage: a population-based study publication-title: Am J Gastroenterol – volume: 2 start-page: 635 year: 2017 ident: 10.1016/j.bpg.2019.04.003_bib74 article-title: Derivation and validation of a novel risk score for safe discharge after acute lower gastrointestinal bleeding: a modelling study publication-title: Lancet Gastroenterol Hepatology doi: 10.1016/S2468-1253(17)30150-4 – volume: 13 year: 2015 ident: 10.1016/j.bpg.2019.04.003_bib50 article-title: Risk of upper and lower gastrointestinal bleeding in patients taking nonsteroidal anti-inflammatory drugs, antiplatelet agents, or anticoagulants publication-title: Clin Gastroenterol Hepatol : Off Clin Pract J Am Gastroenterol Assoc doi: 10.1016/j.cgh.2014.11.007 – volume: 67 start-page: 422 year: 2008 ident: 10.1016/j.bpg.2019.04.003_bib56 article-title: An evaluation of endoscopic indications and findings related to nonvariceal upper-GI hemorrhage in a large multicenter consortium publication-title: Gastrointest Endosc doi: 10.1016/j.gie.2007.09.024 – volume: 13 year: 2015 ident: 10.1016/j.bpg.2019.04.003_bib75 article-title: Performance of new thresholds of the Glasgow Blatchford score in managing patients with upper gastrointestinal bleeding publication-title: Clin Gastroenterol Hepatol : Off. Clin. Pract. J. Am. Gastroenterol. Assoc. doi: 10.1016/j.cgh.2014.07.023 – volume: 104 start-page: 1633 year: 2009 ident: 10.1016/j.bpg.2019.04.003_bib2 article-title: Time trends and impact of upper and lower gastrointestinal bleeding and perforation in clinical practice publication-title: Am J Gastroenterol doi: 10.1038/ajg.2009.164 – year: 2017 ident: 10.1016/j.bpg.2019.04.003_bib42 article-title: Re-bleeding and mortality after lower gastrointestinal bleeding in patients taking anti-platelets or anti-coagulants – volume: 20 start-page: 17568 year: 2014 ident: 10.1016/j.bpg.2019.04.003_bib9 article-title: Upper-gastrointestinal bleeding secondary to peptic ulcer disease: incidence and outcomes publication-title: World J Gastroenterol doi: 10.3748/wjg.v20.i46.17568 – volume: 13 start-page: 70 year: 2010 ident: 10.1016/j.bpg.2019.04.003_bib72 article-title: The economics of upper gastrointestinal bleeding in a US managed-care setting: a retrospective, claims-based analysis publication-title: J Med Econ – volume: 60 start-page: 1327 year: 2011 ident: 10.1016/j.bpg.2019.04.003_bib16 article-title: Acute upper gastrointestinal bleeding in the UK: patient characteristics, diagnoses and outcomes in the 2007 UK audit publication-title: Gut doi: 10.1136/gut.2010.228437 – volume: 5 year: 2015 ident: 10.1016/j.bpg.2019.04.003_bib69 article-title: Costs and quality of life associated with acute upper gastrointestinal bleeding in the UK: cohort analysis of patients in a cluster randomised trial publication-title: BMJ open doi: 10.1136/bmjopen-2014-007230 – volume: 113 start-page: 101 year: 2016 ident: 10.1016/j.bpg.2019.04.003_bib60 article-title: Declining bowel cancer incidence and mortality in Germany publication-title: Deutsches Arzteblatt international – volume: 151 start-page: 271 year: 2016 ident: 10.1016/j.bpg.2019.04.003_bib43 article-title: Risks of bleeding recurrence and cardiovascular events with continued aspirin use after lower gastrointestinal hemorrhage publication-title: Gastroenterology doi: 10.1053/j.gastro.2016.04.013 – volume: 100 start-page: 202 year: 2008 ident: 10.1016/j.bpg.2019.04.003_bib65 article-title: Long-term follow-up of patients with small-bowel angiodysplasia on capsule endoscopy. Determinants of a higher clinical impact and rebleeding rate publication-title: Rev Esp Enferm Dig : Organo Of de la Soc Esp de Patol Dig doi: 10.4321/S1130-01082008000400002 – volume: 79 start-page: 317 year: 2014 ident: 10.1016/j.bpg.2019.04.003_bib66 article-title: Endoscopic hemostasis is rarely used for hematochezia: a population-based study from the clinical outcomes research initiative national endoscopic database publication-title: Gastrointest Endosc doi: 10.1016/j.gie.2013.09.004 – volume: 8 start-page: 47 year: 2015 ident: 10.1016/j.bpg.2019.04.003_bib47 article-title: Conflicting results between randomized trials and observational studies on the impact of proton pump inhibitors on cardiovascular events when coadministered with dual antiplatelet therapy: systematic review publication-title: Circ. Cardiovasc. Qual. Outcomes doi: 10.1161/CIRCOUTCOMES.114.001177 – volume: 163 start-page: 838 year: 2003 ident: 10.1016/j.bpg.2019.04.003_bib21 article-title: Early predictors of severity in acute lower intestinal tract bleeding publication-title: Arch Intern Med doi: 10.1001/archinte.163.7.838 – volume: 25 start-page: 37 year: 2013 ident: 10.1016/j.bpg.2019.04.003_bib14 article-title: Lower gastrointestinal bleeding: incidence, etiology, and outcomes in a population-based setting publication-title: Eur J Gastroenterol Hepatol doi: 10.1097/MEG.0b013e32835948e3 – volume: 31 start-page: 1611 year: 2016 ident: 10.1016/j.bpg.2019.04.003_bib67 article-title: The clinical outcomes of lower gastrointestinal bleeding are not better than those of upper gastrointestinal bleeding publication-title: J Korean Med Sci doi: 10.3346/jkms.2016.31.10.1611 – volume: 77 start-page: 6 year: 2010 ident: 10.1016/j.bpg.2019.04.003_bib34 article-title: Preventing the gastrointestinal adverse effects of nonsteroidal anti-inflammatory drugs: from risk factor identification to risk factor intervention publication-title: Joint Bone Spine : Rev. Rhum. doi: 10.1016/j.jbspin.2009.11.008 – volume: 63 start-page: 1286 year: 2018 ident: 10.1016/j.bpg.2019.04.003_bib8 article-title: Changing epidemiology of upper gastrointestinal hemorrhage in the last decade: a nationwide analysis publication-title: Dig Dis Sci doi: 10.1007/s10620-017-4882-6 – volume: 74 start-page: 675 year: 2015 ident: 10.1016/j.bpg.2019.04.003_bib32 article-title: Gastrointestinal events in at-risk patients starting non-steroidal anti-inflammatory drugs (NSAIDs) for rheumatic diseases: the EVIDENCE study of European routine practice publication-title: Ann Rheum Dis doi: 10.1136/annrheumdis-2013-204155 – volume: 29 start-page: 559 year: 2000 ident: 10.1016/j.bpg.2019.04.003_bib25 article-title: Recent developments in the epidemiology of Helicobacter pylori publication-title: Gastroenterol Clin N Am doi: 10.1016/S0889-8553(05)70130-8 – volume: 94 year: 2015 ident: 10.1016/j.bpg.2019.04.003_bib54 article-title: Use of SSRI, but not SNRI, increased upper and lower gastrointestinal bleeding: a nationwide population-based cohort study in Taiwan publication-title: Medicine doi: 10.1097/MD.0000000000002022 – volume: 141 start-page: 1314 year: 2011 ident: 10.1016/j.bpg.2019.04.003_bib37 article-title: Proton pump inhibitors exacerbate NSAID-induced small intestinal injury by inducing dysbiosis publication-title: Gastroenterology doi: 10.1053/j.gastro.2011.06.075 – volume: 13 year: 2015 ident: 10.1016/j.bpg.2019.04.003_bib52 article-title: Use of selective serotonin reuptake inhibitors and risk of upper gastrointestinal bleeding: a systematic review and meta-analysis publication-title: Clin Gastroenterol Hepatol : Off Clin Pract J Am Gastroenterol Assoc doi: 10.1016/j.cgh.2014.06.021 – volume: 50 start-page: 378 year: 2015 ident: 10.1016/j.bpg.2019.04.003_bib41 article-title: Small bowel injury in low-dose aspirin users publication-title: J Gastroenterol doi: 10.1007/s00535-014-1028-x – volume: 5 start-page: 141 year: 2010 ident: 10.1016/j.bpg.2019.04.003_bib68 article-title: Upper versus lower gastrointestinal bleeding: a direct comparison of clinical presentation, outcomes, and resource utilization publication-title: J Hosp Med doi: 10.1002/jhm.606 – year: 2018 ident: 10.1016/j.bpg.2019.04.003_bib24 article-title: Helicobacter pylori seroprevalence in Spain: influence of adult and childhood sociodemographic factors publication-title: Eur J Cancer Prev : Off J Eur Cancer Prev Organ (ECP) – volume: 46 start-page: 39 year: 2011 ident: 10.1016/j.bpg.2019.04.003_bib45 article-title: Cardiovascular and gastrointestinal events of three antiplatelet therapies: clopidogrel, clopidogrel plus proton-pump inhibitors, and aspirin plus proton-pump inhibitors in patients with previous gastrointestinal bleeding publication-title: J Gastroenterol doi: 10.1007/s00535-010-0299-0 – volume: 5 start-page: 1601 year: 2016 ident: 10.1016/j.bpg.2019.04.003_bib26 article-title: Downward trend in the prevalence of Helicobacter pylori infections and corresponding frequent upper gastrointestinal diseases profile changes in Southeastern China between 2003 and 2012 publication-title: SpringerPlus doi: 10.1186/s40064-016-3185-2 – volume: 29 start-page: 1786 year: 2014 ident: 10.1016/j.bpg.2019.04.003_bib22 article-title: Colonic diverticular hemorrhage associated with the use of nonsteroidal anti-inflammatory drugs, low-dose aspirin, antiplatelet drugs, and dual therapy publication-title: J Gastroenterol Hepatol doi: 10.1111/jgh.12595 – volume: 4 start-page: 1459 year: 2006 ident: 10.1016/j.bpg.2019.04.003_bib62 article-title: Trends in management and outcomes of acute nonvariceal upper gastrointestinal bleeding: 1993-2003. Clinical gastroenterology and hepatology : the official clinical practice publication-title: J Am Gastroenterol Assoc – volume: 133 start-page: 1697 year: 2007 ident: 10.1016/j.bpg.2019.04.003_bib1 article-title: American Gastroenterological Association (AGA) Institute technical review on obscure gastrointestinal bleeding publication-title: Gastroenterology doi: 10.1053/j.gastro.2007.06.007 – volume: 21 start-page: 10890 year: 2015 ident: 10.1016/j.bpg.2019.04.003_bib10 article-title: Upper gastrointestinal bleeding in Scotland 2000-2010: improved outcomes but a significant weekend effect publication-title: World J Gastroenterol doi: 10.3748/wjg.v21.i38.10890 – volume: 109 start-page: 811 year: 2014 ident: 10.1016/j.bpg.2019.04.003_bib53 article-title: Risk of upper gastrointestinal bleeding with selective serotonin reuptake inhibitors with or without concurrent nonsteroidal anti-inflammatory use: a systematic review and meta-analysis publication-title: Am J Gastroenterol doi: 10.1038/ajg.2014.82 – volume: 152 start-page: 337 year: 2010 ident: 10.1016/j.bpg.2019.04.003_bib44 article-title: Outcomes with concurrent use of clopidogrel and proton-pump inhibitors: a cohort study publication-title: Ann Intern Med doi: 10.7326/0003-4819-152-6-201003160-00003 – volume: 5 year: 2017 ident: 10.1016/j.bpg.2019.04.003_bib76 article-title: Diagnostic and therapeutic treatment modalities for acute lower gastrointestinal bleeding: a systematic review publication-title: Endosc Int Open – volume: 10 start-page: 453 year: 2015 ident: 10.1016/j.bpg.2019.04.003_bib13 article-title: Esophageal variceal bleeding in hospitalized patients with cirrhosis publication-title: J Hosp Med doi: 10.1002/jhm.2360 – volume: 6 start-page: 1004 year: 2008 ident: 10.1016/j.bpg.2019.04.003_bib20 article-title: Risk factors for mortality in lower intestinal bleeding publication-title: Clin Gastroenterol Hepatol : Off Clin Pract J Am Gastroenterol Assoc doi: 10.1016/j.cgh.2008.03.021 – volume: 96 start-page: 606 year: 1989 ident: 10.1016/j.bpg.2019.04.003_bib40 article-title: Aspirin-induced gastric mucosal injury: lessons learned from animal models publication-title: Gastroenterology doi: 10.1016/S0016-5085(89)80056-3 – volume: 33 start-page: 585 year: 2011 ident: 10.1016/j.bpg.2019.04.003_bib7 article-title: The changing face of hospitalisation due to gastrointestinal bleeding and perforation publication-title: Aliment Pharmacol Ther doi: 10.1111/j.1365-2036.2010.04563.x – volume: 141 start-page: 62 year: 2011 ident: 10.1016/j.bpg.2019.04.003_bib63 article-title: Reductions in 28-day mortality following hospital admission for upper gastrointestinal hemorrhage publication-title: Gastroenterology doi: 10.1053/j.gastro.2011.03.048 – volume: 67 start-page: 654 year: 2018 ident: 10.1016/j.bpg.2019.04.003_bib18 article-title: Acute lower GI bleeding in the UK: patient characteristics, interventions and outcomes in the first nationwide audit publication-title: Gut – volume: 14 year: 2016 ident: 10.1016/j.bpg.2019.04.003_bib36 article-title: Proton pump inhibitors increase incidence of nonsteroidal anti-inflammatory drug-induced small bowel injury: a randomized, placebo-controlled trial. Clinical gastroenterology and hepatology : the official clinical practice publication-title: J Am Gastroenterol Assoc – volume: 17 start-page: 1 year: 2006 ident: 10.1016/j.bpg.2019.04.003_bib46 article-title: Upper gastrointestinal haemorrhage complicating antiplatelet treatment with aspirin and/or clopidogrel: where we are now? publication-title: Platelets doi: 10.1080/09537100500237004 – volume: 23 start-page: 147 year: 2014 ident: 10.1016/j.bpg.2019.04.003_bib59 article-title: Increasing prevalence of right-sided colonic adenomas in a high-volume endoscopy department in Romania: implications for colorectal cancer screening publication-title: J Gastrointest Liver Dis : JGLD doi: 10.15403/jgld.2014.1121.232.iiv1 – volume: 11 start-page: 1 year: 2008 ident: 10.1016/j.bpg.2019.04.003_bib70 article-title: Estimates of costs of hospital stay for variceal and nonvariceal upper gastrointestinal bleeding in the United States. Value in health publication-title: J Int Soc Pharmacoecon Outcomes Res – volume: 153 start-page: 420 year: 2017 ident: 10.1016/j.bpg.2019.04.003_bib23 article-title: Global prevalence of Helicobacter pylori infection: systematic review and meta-analysis publication-title: Gastroenterology doi: 10.1053/j.gastro.2017.04.022 – volume: 300 start-page: 754 year: 2002 ident: 10.1016/j.bpg.2019.04.003_bib29 article-title: Up-regulation of cyclooxygenase-2 by inhibition of cyclooxygenase-1: a key to nonsteroidal anti-inflammatory drug-induced intestinal damage publication-title: J Pharmacol Exp Ther doi: 10.1124/jpet.300.3.754 – volume: 108 start-page: 392 year: 2013 ident: 10.1016/j.bpg.2019.04.003_bib31 article-title: A novel 6-month, prospective, randomized, open-label, blinded endpoint (PROBE) trial publication-title: Am J Gastroenterol doi: 10.1038/ajg.2012.467 – volume: 11 year: 2016 ident: 10.1016/j.bpg.2019.04.003_bib39 article-title: Systematic review and meta-analysis of randomised trials to ascertain fatal gastrointestinal bleeding events attributable to preventive low-dose aspirin: No evidence of increased risk publication-title: PLoS One doi: 10.1371/journal.pone.0166166 |
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| Title | Changing epidemiology and etiology of upper and lower gastrointestinal bleeding |
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