MINIATURIZED HPLC-UV METHOD FOR ANALYSIS OF COENZYME Q10 IN HUMAN PLASMA

• Published in: Journal of liquid chromatography & related technologies Vol. 34; no. 20; pp. 2485 - 2494
• Main Authors: Contin, Mario, Lucangioli, Silvia, Martinefski, Manuela, Flor, Sabrina, Tripodi, Valeria
• Format: Journal Article
• Language: English
• Published: Colchester Taylor & Francis Group 01.12.2011; Taylor & Francis; Taylor & Francis Ltd
• Subjects: Biological and medical sciences; coenzyme Q10; CoQ10, coenzyme Q10; EC, electrochemical detection; Evaporation; HPLC, high performance liquid chromatography; Investigative techniques, diagnostic techniques (general aspects); Liquid chromatography; LOD, limit of detection; LOQ, limit of quantitation; Medical sciences; micro fast HPLC; microcolumn; Miscellaneous. Technology; mitochondrial disease; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; plasma; UV, ultraviolet; Biological fluid; coenzyme Q10; Chemical analysis; HPLC chromatography; Enzymopathy; Mitochondrial disorder; Blood; mitochondrial disease; Blood plasma; Ubiquinone; Fast HPLC chromatography; microcolumn; Clinical biology; Quantitative analysis; Human; Validation; UV; Healthy subject; Quinone; Metabolic diseases; Routine analysis; Patient; Genetic disease; Coenzyme; Microbore column; Ultraviolet detector; Treatment; Miniaturization; micro fast HPLC; plasma

Coenzyme Q10 (CoQ10) is a cofactor in the respiratory chain and a potent endogenous antioxidant. Abnormally low levels of CoQ10 in the circulatory system are often involved with pathological states such as heart failure, mitochondrial and muscular diseases, and cancer. The development of simple, rap...