Prevalence and genetic basis of Mycobacterium tuberculosis resistance to pretomanid in China

• Published in: Annals of clinical microbiology and antimicrobials Vol. 23; no. 1; p. 40
• Main Authors: Zhao, Bing, Zheng, Huiwen, Timm, Juliano, Song, Zexuan, Pei, Shaojun, Xing, Ruida, Guo, Yajie, Ma, Ling, Li, Feina, Li, Qing, Li, Yan, Huang, Lin, Teng, Chong, Wang, Ni, Gupta, Aastha, Juneja, Sandeep, Huang, Fei, Zhao, Yanlin, Ou, Xichao
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 03.05.2024; BMC
• Subjects: Antitubercular Agents - pharmacology; Breakpoint; Care and treatment; China - epidemiology; Drug resistance; Drug resistance in microorganisms; Epidemiology; Forecasts and trends; Genetic aspects; Genotype; Humans; Microbial Sensitivity Tests; Mutation; Mycobacterium tuberculosis; Mycobacterium tuberculosis - drug effects; Mycobacterium tuberculosis - genetics; Mycobacterium tuberculosis - isolation & purification; Nitroimidazoles - pharmacology; Patient outcomes; Pretomanid; Prevalence; Resistance; Rifabutin; Tuberculosis; Tuberculosis, Multidrug-Resistant - epidemiology; Tuberculosis, Multidrug-Resistant - microbiology; Whole Genome Sequencing; China; Resistance; Breakpoint; Pretomanid; Mutation

Pretomanid is a key component of new regimens for the treatment of drug-resistant tuberculosis (TB) which are being rolled out globally. However, there is limited information on the prevalence of pre-existing resistance to the drug. To investigate pretomanid resistance rates in China and its underly...