Oxidative stress and mitochondrial dysfunction mediated Cd-induced hepatic lipid accumulation in zebrafish Danio rerio

• Published in: Aquatic toxicology Vol. 199; pp. 12 - 20
• Main Authors: Pan, Ya-Xiong, Luo, Zhi, Zhuo, Mei-Qing, Wei, Chuan-Chuan, Chen, Guang-Hui, Song, Yu-Feng
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2018
• Subjects: acetyl-CoA carboxylase; acetylcysteine; adenosine triphosphate; adults; Cadmium; cadmium chloride; carboxylic ester hydrolases; carnitine palmitoyltransferase; cyclosporine; cytochrome-c oxidase; Danio rerio; fatty-acid synthase; fish; gene expression; genes; glucose 6-phosphate; Lipid metabolism; liver; malic enzyme; membrane potential; messenger RNA; mitochondria; Mitochondrial dysfunction; mitochondrial membrane; mitophagy; NADP-glucose-6-phosphate dehydrogenase; Oxidative stress; permeability; peroxidase; phosphogluconate dehydrogenase; reactive oxygen species; superoxide dismutase; toxicology; triacylglycerol lipase; triacylglycerols; Cd; Oxidative stress; LAMP 2; ATGL; Danio rerio; MDA; MPT; ACOX; ME; acaca; MFN2; Lipid metabolism; LC3; HSL; Cadmium; G6PD; Mitochondrial dysfunction; parkin; SOD; COX; 6PGD; GPx; CsA; MMP; NAC; PINK1; TG; CAT; ROS; FAS; ICDH; NIX; CPTI
• ISSN: 0166-445X; 1879-1514; 1879-1514
• DOI: 10.1016/j.aquatox.2018.03.017

•Waterborne Cd exposure increased hepatic TG and Cd accumulation.•Increased TG content is attributable to increased lipogenesis and reduced lipolysis after Cd exposure.•The oxidative stress and mitochondrial dysfunction mediated Cd-induced disorder of lipid metabolism.•A novel mechanism was proposed...