Distal Evaluation of Functional performance with Intravascular sensors to assess the Narrowing Effect—combined pressure and Doppler FLOW velocity measurements (DEFINE-FLOW) trial: Rationale and trial design

• Published in: The American heart journal Vol. 222; pp. 139 - 146
• Main Authors: Stegehuis, Valérie E., Wijntjens, Gilbert W.M., van de Hoef, Tim P., Casadonte, Lorena, Kirkeeide, Richard L., Siebes, Maria, Spaan, Jos A.E., Gould, K. Lance, Johnson, Nils P., Piek, Jan J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2020; Elsevier Limited
• Subjects: Adenosine; Aged; Angina; Angina pectoris; Blood Flow Velocity - physiology; Cardiac Catheterization - methods; Cardiovascular disease; Catheters; Clinical medicine; Coronary Stenosis - diagnosis; Coronary Stenosis - physiopathology; Coronary vessels; Coronary Vessels - diagnostic imaging; Coronary Vessels - physiopathology; Doppler effect; Echocardiography, Doppler; Enrollments; Female; Flow velocity; Follow-Up Studies; Fractional Flow Reserve, Myocardial - physiology; Health services; Heart attacks; Heart rate; Heart surgery; Humans; Intubation; Laboratories; Lesions; Male; Medical treatment; Monitoring, Physiologic - instrumentation; Myocardial infarction; Predictive Value of Tests; Pressure effects; Prospective Studies; Reproducibility of Results; Sensors; Severity of Illness Index; Volcanoes; Denmark; Netherlands; Japan; Aarhus Denmark

It remains uncertain if invasive coronary physiology beyond fractional flow reserve (FFR) can refine lesion selection for revascularization or provide additional prognostic value. Coronary flow reserve (CFR) equals the ratio of hyperemic to baseline flow velocity and has a wealth of invasive and non...