Overexpression of the nucleocapsid protein of Middle East respiratory syndrome coronavirus up-regulates CXCL10

• Published in: Bioscience reports Vol. 38; no. 5
• Main Authors: Aboagye, James Odame, Yew, Chow Wenn, Ng, Oi-Wing, Monteil, Vanessa M, Mirazimi, Ali, Tan, Yee-Joo
• Format: Journal Article
• Language: English
• Published: England Portland Press Ltd 31.10.2018
• Subjects: A549 Cells; Chemokine CXCL10 - genetics; Coronavirus Infections - genetics; Coronavirus Infections - pathology; Coronavirus Infections - virology; Gene Expression Regulation, Viral - genetics; Host-Pathogen Interactions - genetics; Humans; Medicin och hälsovetenskap; Middle East Respiratory Syndrome Coronavirus - genetics; Middle East Respiratory Syndrome Coronavirus - pathogenicity; Nucleocapsid Proteins - genetics; Protein Domains - genetics; Transcriptional Activation - genetics; nucleocapsid; CXCL10; Middle East Respiratory Syndrome coronavirus

Middle East respiratory syndrome coronavirus (MERS-CoV) causes respiratory diseases in humans and has a high mortality rate. During infection, MERS-CoV regulates several host cellular processes including antiviral response genes. In order to determine if the nucleocapsid protein of MERS-CoV (MERS-N)...