Zika Virus Induced Mortality and Microcephaly in Chicken Embryos

• Published in: Stem cells and development Vol. 25; no. 22; p. 1691
• Main Authors: Goodfellow, Forrest T, Tesla, Blanka, Simchick, Gregory, Zhao, Qun, Hodge, Thomas, Brindley, Melinda A, Stice, Steven L
• Format: Journal Article
• Language: English
• Published: United States 15.11.2016
• Subjects: Animals; Brain - embryology; Brain - pathology; Brain - virology; Chick Embryo; Magnetic Resonance Imaging; Microcephaly - pathology; Microcephaly - virology; Zika Virus - physiology; Zika Virus Infection - pathology; microcephaly; embryo; Zika

The explosive spread of the Zika virus (ZIKV) through South and Central America has been linked to an increase in congenital birth defects, specifically microcephaly. Representative rodent models for investigating infections include direct central nervous system (CNS) injections late in pregnancy an...