Functional Epitopes for Anti–Aquaporin 5 Antibodies in Sjögren Syndrome

• Published in: Journal of dental research Vol. 96; no. 12; pp. 1414 - 1421
• Main Authors: Alam, J., Koh, J.H., Kwok, S.-K., Park, S.-H., Park, K., Choi, Y.
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.11.2017; SAGE PUBLICATIONS, INC
• Subjects: Amino Acid Sequence; Aquaporin 5; Aquaporin 5 - antagonists & inhibitors; Aquaporins; Autoantibodies; Autoantibodies - immunology; Data analysis; Epitopes; Epitopes - immunology; Fluorescent Antibody Technique, Indirect; Humans; Immunofluorescence; Immunoglobulin G; Immunoglobulin G - immunology; Immunoglobulins; Mimicry; Peptides; Peptides - immunology; Permeability; Sjogren's syndrome; Sjogren's Syndrome - immunology; Therapeutic applications; rheumatology; oral medicine; autoimmunity; MDCK cells; indirect immunofluorescence assay; salivary physiology

We recently reported the presence of anti–aquaporin 5 (AQP5) immunoglobulin G (IgG) in patients with primary Sjögren syndrome (SS) with a sensitivity of 0.73 and a specificity of 0.68. The aim of this study was to identify functional epitopes for the anti-AQP5 autoantibodies detected in control subj...