Network-based drug repurposing for schizophrenia

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 49; no. 6; pp. 983 - 992
• Main Authors: Truong, Trang T. T., Liu, Zoe S. J., Panizzutti, Bruna, Kim, Jee Hyun, Dean, Olivia M., Berk, Michael, Walder, Ken
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.05.2024; Springer International Publishing
• Subjects: Algorithms; Antipsychotic Agents - pharmacology; Antipsychotic Agents - therapeutic use; Cell adhesion; Computational neuroscience; Computer programs; Drug Repositioning - methods; Energy metabolism; Gene Regulatory Networks - drug effects; Genes; Humans; Immune response; Immunosuppressive agents; Kaempferol; Mental disorders; Protein interaction; Schizophrenia; Schizophrenia - drug therapy; Schizophrenia - genetics; Schizophrenia - metabolism; Signal transduction; Transcription Factors - genetics; Transcription Factors - metabolism

Despite recent progress, the challenges in drug discovery for schizophrenia persist. However, computational drug repurposing has gained popularity as it leverages the wealth of expanding biomedical databases. Network analyses provide a comprehensive understanding of transcription factor (TF) regulat...