Association Between GSTP1 Ile105Val Genetic Polymorphism and Dependency to Heroin and Opium

• Published in: Biochemical genetics Vol. 57; no. 2; pp. 214 - 221
• Main Authors: Rezaei, Majede, Saadat, Mostafa
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.04.2019; Springer Nature B.V
• Subjects: Amino acids; Biochemistry; Biomedical and Life Sciences; Biomedicine; blood donors; case-control studies; Dependence; Detoxification; Drug abuse; Enzymatic activity; Enzyme activity; Gene polymorphism; genetic polymorphism; genotype; Genotypes; Genotyping; Glutathione; Glutathione transferase; Heroin; Human Genetics; Medical Microbiology; Narcotics; Original Article; Oxidative stress; polymerase chain reaction; Polymorphism; Risk; Zoology; Heroin dependency; Opium dependency; Polymorphism; GSTP1

Relationship between glutathione S-transferase P1 ( GSTP1 , OMIM: 134660) variants and the risk of drug dependency is unknown. Chronic use of illegal drugs leads to oxidative stress, which can be alleviated by cellular detoxification mechanisms. There are several polymorphisms in the GSTP1 , includi...