Pyridinyl Imidazole Inhibitors of p38 Mitogen-activated Protein Kinase Bind in the ATP Site

The site of action of a series of pyridinyl imidazole compounds that are selective inhibitors of p38 mitogen-activated protein kinase in vitro and block proinflammatory cytokine production in vivo has been determined. Using Edman sequencing, 125 I-SB206718 was shown to cross-link to the nonphosphory...

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Bibliographic Details
Published inThe Journal of biological chemistry Vol. 272; no. 18; pp. 12116 - 12121
Main Authors Young, P R, McLaughlin, M M, Kumar, S, Kassis, S, Doyle, M L, McNulty, D, Gallagher, T F, Fisher, S, McDonnell, P C, Carr, S A, Huddleston, M J, Seibel, G, Porter, T G, Livi, G P, Adams, J L, Lee, J C
Format Journal Article
LanguageEnglish
Published United States American Society for Biochemistry and Molecular Biology 02.05.1997
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