Determination of lead in bone tissues by axially viewed inductively coupled plasma multichannel-based emission spectrometry
A new procedure for determining low levels of lead in bone tissues has been developed. After wet acid digestion in a pressurized microwave-heated system, the solution was analyzed by inductively coupled plasma multichannel-based emission spectrometry. Internal standardization using the Co 228.615 nm...
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Published in | Analytical and bioanalytical chemistry Vol. 381; no. 7; pp. 1395 - 1400 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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01.04.2005
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Abstract | A new procedure for determining low levels of lead in bone tissues has been developed. After wet acid digestion in a pressurized microwave-heated system, the solution was analyzed by inductively coupled plasma multichannel-based emission spectrometry. Internal standardization using the Co 228.615 nm reference line was chosen as the optimal method to compensate for the matrix effects from the presence of calcium and nitric acid at high concentration levels. The detection limit of the procedure was 0.11 microg Pb g(-1) dry mass. Instrumental precision at the analytical concentration of approximately 10 microg l(-1) ranged from 6.1 to 9.4%. Precision of the sample preparation step was 5.4%. The concentration of lead in SRM 1486 (1.32+/-0.04 microg g(-1)) found using the new procedure was in excellent agreement with the certified level (1.335+/-0.014 microg g(-1)). Finally, the method was applied to determine the lead in various fish bone tissues, and the analytical results were found to be in good agreement with those obtained through differential pulse anodic stripping voltammetry. The method is therefore suitable for the reliable determination of lead at concentration levels of below 1 microg g(-1) in bone samples. Moreover, the multi-element capability of the technique allows us to simultaneously determine other major or trace elements in order to investigate inter-element correlation and to compute enrichment factors, making the proposed procedure particularly useful for investigating lead occurrence and pathways in fish bone tissues in order to find suitable biomarkers for the Antarctic marine environment. |
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AbstractList | A new procedure for determining low levels of lead in bone tissues has been developed. After wet acid digestion in a pressurized microwave-heated system, the solution was analyzed by inductively coupled plasma multichannel-based emission spectrometry. Internal standardization using the Co 228.615 nm reference line was chosen as the optimal method to compensate for the matrix effects from the presence of calcium and nitric acid at high concentration levels. The detection limit of the procedure was 0.11 mu g Pb g super(-1) dry mass. Instrumental precision at the analytical concentration of similar to 10 mu g l super(-1) ranged from 6.1 to 9.4%. Precision of the sample preparation step was 5.4%. The concentration of lead in SRM 1486 (1.32 plus or minus 0.04 mu g g super(-1)) found using the new procedure was in excellent agreement with the certified level (1.335 plus or minus 0.014 mu g g super(-1)). Finally, the method was applied to determine the lead in various fish bone tissues, and the analytical results were found to be in good agreement with those obtained through differential pulse anodic stripping voltammetry. The method is therefore suitable for the reliable determination of lead at concentration levels of below 1 mu g g super(-1) in bone samples. Moreover, the multi-element capability of the technique allows us to simultaneously determine other major or trace elements in order to investigate inter-element correlation and to compute enrichment factors, making the proposed procedure particularly useful for investigating lead occurrence and pathways in fish bone tissues in order to find suitable biomarkers for the Antarctic marine environment. A new procedure for determining low levels of lead in bone tissues has been developed. After wet acid digestion in a pressurized microwave-heated system, the solution was analyzed by inductively coupled plasma multichannel-based emission spectrometry. Internal standardization using the Co 228.615 nm reference line was chosen as the optimal method to compensate for the matrix effects from the presence of calcium and nitric acid at high concentration levels. The detection limit of the procedure was 0.11 microg Pb g(-1) dry mass. Instrumental precision at the analytical concentration of approximately 10 microg l(-1) ranged from 6.1 to 9.4%. Precision of the sample preparation step was 5.4%. The concentration of lead in SRM 1486 (1.32+/-0.04 microg g(-1)) found using the new procedure was in excellent agreement with the certified level (1.335+/-0.014 microg g(-1)). Finally, the method was applied to determine the lead in various fish bone tissues, and the analytical results were found to be in good agreement with those obtained through differential pulse anodic stripping voltammetry. The method is therefore suitable for the reliable determination of lead at concentration levels of below 1 microg g(-1) in bone samples. Moreover, the multi-element capability of the technique allows us to simultaneously determine other major or trace elements in order to investigate inter-element correlation and to compute enrichment factors, making the proposed procedure particularly useful for investigating lead occurrence and pathways in fish bone tissues in order to find suitable biomarkers for the Antarctic marine environment. A new procedure for determining low levels of lead in bone tissues has been developed. After wet acid digestion in a pressurized microwave-heated system, the solution was analyzed by inductively coupled plasma multichannel-based emission spectrometry. Internal standardization using the Co 228.615 nm reference line was chosen as the optimal method to compensate for the matrix effects from the presence of calcium and nitric acid at high concentration levels. The detection limit of the procedure was 0.11 g Pb g dry mass. Instrumental precision at the analytical concentration of ~10 g l ranged from 6.1 to 9.4%. Precision of the sample preparation step was 5.4%. The concentration of lead in SRM 1486 (1.32+/-0.04 g g) found using the new procedure was in excellent agreement with the certified level (1.335+/-0.014 g g). Finally, the method was applied to determine the lead in various fish bone tissues, and the analytical results were found to be in good agreement with those obtained through differential pulse anodic stripping voltammetry. The method is therefore suitable for the reliable determination of lead at concentration levels of below 1 g g in bone samples. Moreover, the multi-element capability of the technique allows us to simultaneously determine other major or trace elements in order to investigate inter-element correlation and to compute enrichment factors, making the proposed procedure particularly useful for investigating lead occurrence and pathways in fish bone tissues in order to find suitable biomarkers for the Antarctic marine environment. |
Author | Grotti, Marco Dalla Riva, Simona Abelmoschi, Maria Luisa Soggia, Francesco Frache, Roberto |
Author_xml | – sequence: 1 givenname: Marco surname: Grotti fullname: Grotti, Marco email: grotti@chimica.unige.it organization: Department of Chemistry and Industrial Chemistry, University of Genoa, Via Dodecaneso 31, 16146 Genoa, Italy. grotti@chimica.unige.it – sequence: 2 givenname: Maria Luisa surname: Abelmoschi fullname: Abelmoschi, Maria Luisa – sequence: 3 givenname: Simona surname: Dalla Riva fullname: Dalla Riva, Simona – sequence: 4 givenname: Francesco surname: Soggia fullname: Soggia, Francesco – sequence: 5 givenname: Roberto surname: Frache fullname: Frache, Roberto |
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CitedBy_id | crossref_primary_10_1007_s00216_008_2050_8 crossref_primary_10_1016_j_talanta_2012_11_043 crossref_primary_10_1002_mnfr_201600118 crossref_primary_10_1016_j_jhazmat_2010_06_057 crossref_primary_10_1039_b601116k crossref_primary_10_1039_C8AY02555J crossref_primary_10_1016_j_microc_2013_07_001 |
Cites_doi | 10.1016/S0048-9697(00)00448-4 10.1016/S0003-2670(00)85034-5 10.1016/0048-9697(95)04218-P 10.1289/ehp.94102172 10.1016/S0168-583X(03)01675-6 10.1039/b304215d 10.1016/0584-8547(94)80138-X 10.1007/BF02036476 10.1016/S0009-8981(99)00239-9 10.1039/b212653b 10.1016/S0013-9351(05)80248-8 10.1016/0048-9697(87)90252-X 10.1016/S0379-0738(01)00614-4 10.1016/S0584-8547(98)00161-X 10.1007/s002160100917 10.1016/S0584-8547(99)00041-5 10.1039/ja9961100025 10.1016/S0168-583X(03)01059-0 10.1016/S0584-8547(01)00171-9 10.1093/clinchem/45.9.1548 10.1016/S0168-583X(99)00305-5 10.4319/lo.1997.42.1.0102 |
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References | SR Thorrold (3057_CR13) 1997; 42 NW Barnett (3057_CR17) 1987; 198 Deibel (3057_CR18) 1995; 195 Todol (3057_CR23) 1999; 54 RE Thresher (3057_CR12) 1994; 92 ML Abelmoschi (3057_CR10) 2000; 90 Brenn (3057_CR4) 1999; 158 PC D’Haese (3057_CR7) 1999; 45 3057_CR5 MW Warren (3057_CR14) 2002; 125 3057_CR27 Stepan (3057_CR24) 2001; 56 J Scancar (3057_CR8) 2000; 293 Zong (3057_CR20) 1996; 11 Zong (3057_CR21) 1998; 53 Grotti (3057_CR25) 2003; 18 GA Drasch (3057_CR1) 1987; 64 HW Kuo (3057_CR6) 2000; 255 BE Saltzman (3057_CR2) 1990; 52 Zong (3057_CR19) 1994; 49 Iavicoli (3057_CR22) 2001; 370 I Baranowska (3057_CR3) 1995; 159 Todd (3057_CR15) 1994; 102 Grotti (3057_CR26) 2003; 18 Edmons (3057_CR11) 1991; 46 Nie (3057_CR16) 2004; 213 Orlic (3057_CR9) 2003; 210 |
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SubjectTerms | Animals Bone and Bones - chemistry Fishes Lead - analysis Spectrophotometry, Atomic - methods |
Title | Determination of lead in bone tissues by axially viewed inductively coupled plasma multichannel-based emission spectrometry |
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