Global loss of myelin water over 5 years in multiple sclerosis normal-appearing white matter

• Published in: Multiple sclerosis Vol. 24; no. 12; p. 1557
• Main Authors: Vavasour, Irene M, Huijskens, Sophie C, Li, David Kb, Traboulsee, Anthony L, Mädler, Burkhard, Kolind, Shannon H, Rauscher, Alexander, Moore, Gr Wayne, MacKay, Alex L, Laule, Cornelia
• Format: Journal Article
• Language: English
• Published: England 01.10.2018
• Subjects: normal-appearing white matter; Multiple sclerosis; myelin water fraction; longitudinal

Reduced myelin water fraction (MWF, a marker for myelin), increased geometric mean T (ieGMT , reflecting intra/extracellular water properties), and increased T (related to total water content) have been observed in cross-sectional studies of multiple sclerosis (MS) normal-appearing white matter (NAW...