Global loss of myelin water over 5 years in multiple sclerosis normal-appearing white matter

Reduced myelin water fraction (MWF, a marker for myelin), increased geometric mean T (ieGMT , reflecting intra/extracellular water properties), and increased T (related to total water content) have been observed in cross-sectional studies of multiple sclerosis (MS) normal-appearing white matter (NAW...

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Published inMultiple sclerosis Vol. 24; no. 12; p. 1557
Main Authors Vavasour, Irene M, Huijskens, Sophie C, Li, David Kb, Traboulsee, Anthony L, Mädler, Burkhard, Kolind, Shannon H, Rauscher, Alexander, Moore, Gr Wayne, MacKay, Alex L, Laule, Cornelia
Format Journal Article
LanguageEnglish
Published England 01.10.2018
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Abstract Reduced myelin water fraction (MWF, a marker for myelin), increased geometric mean T (ieGMT , reflecting intra/extracellular water properties), and increased T (related to total water content) have been observed in cross-sectional studies of multiple sclerosis (MS) normal-appearing white matter (NAWM). To assess longitudinal changes of magnetic resonance (MR) measures in relapsing-remitting MS (RRMS) brain NAWM. A total of 11 subjects with RRMS and 4 controls were scanned on a 3T MRI at baseline and long-term follow-up (LTFU; 3.2-5.8 years) with a 32-echo T relaxation and an inversion recovery T sequence. For every voxel, MWF, ieGMT , and T were obtained. Mean, peak height, and peak location from NAWM mask-based histograms were determined. In MS subjects, NAWM MWF mean decreased by 8% ( p = 0.0016). No longitudinal changes were measured in T or ieGMT . There was no relationship between change in any MR metric and change in EDSS. Control white matter showed no differences over time in any metric. The decreases we observed in MWF suggest that changes in myelin integrity and loss of myelin may be occurring diffusely and over long time periods in the MS brain. The timescale of these changes indicates that chronic, progressive myelin damage is an evolving process occurring over many years.
AbstractList Reduced myelin water fraction (MWF, a marker for myelin), increased geometric mean T (ieGMT , reflecting intra/extracellular water properties), and increased T (related to total water content) have been observed in cross-sectional studies of multiple sclerosis (MS) normal-appearing white matter (NAWM). To assess longitudinal changes of magnetic resonance (MR) measures in relapsing-remitting MS (RRMS) brain NAWM. A total of 11 subjects with RRMS and 4 controls were scanned on a 3T MRI at baseline and long-term follow-up (LTFU; 3.2-5.8 years) with a 32-echo T relaxation and an inversion recovery T sequence. For every voxel, MWF, ieGMT , and T were obtained. Mean, peak height, and peak location from NAWM mask-based histograms were determined. In MS subjects, NAWM MWF mean decreased by 8% ( p = 0.0016). No longitudinal changes were measured in T or ieGMT . There was no relationship between change in any MR metric and change in EDSS. Control white matter showed no differences over time in any metric. The decreases we observed in MWF suggest that changes in myelin integrity and loss of myelin may be occurring diffusely and over long time periods in the MS brain. The timescale of these changes indicates that chronic, progressive myelin damage is an evolving process occurring over many years.
Author MacKay, Alex L
Li, David Kb
Vavasour, Irene M
Mädler, Burkhard
Laule, Cornelia
Rauscher, Alexander
Huijskens, Sophie C
Traboulsee, Anthony L
Moore, Gr Wayne
Kolind, Shannon H
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  givenname: Irene M
  surname: Vavasour
  fullname: Vavasour, Irene M
  organization: Department of Radiology, The University of British Columbia, Vancouver, BC, Canada
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  givenname: Sophie C
  surname: Huijskens
  fullname: Huijskens, Sophie C
  organization: Department of Physics and Astronomy, The University of British Columbia, Vancouver, BC, Canada
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  givenname: David Kb
  surname: Li
  fullname: Li, David Kb
  organization: Department of Radiology, The University of British Columbia, Vancouver, BC, Canada; Department of Medicine, The University of British Columbia, Vancouver, BC, Canada
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  givenname: Anthony L
  surname: Traboulsee
  fullname: Traboulsee, Anthony L
  organization: Department of Medicine, The University of British Columbia, Vancouver, BC, Canada
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  givenname: Burkhard
  surname: Mädler
  fullname: Mädler, Burkhard
  organization: Philips Healthcare, Hamburg, Germany
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  givenname: Shannon H
  surname: Kolind
  fullname: Kolind, Shannon H
  organization: Department of Radiology, The University of British Columbia, Vancouver, BC, Canada; Department of Medicine, The University of British Columbia, Vancouver, BC, Canada
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  surname: Rauscher
  fullname: Rauscher, Alexander
  organization: Paediatrics, Centre for Brain Health, Child and Family Research Institute, The University of British Columbia, Vancouver, BC, Canada
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  givenname: Gr Wayne
  surname: Moore
  fullname: Moore, Gr Wayne
  organization: Department of Medicine, The University of British Columbia, Vancouver, BC, Canada/Department of Pathology and Laboratory Medicine, The University of British Columbia, Vancouver, BC, Canada/International Collaboration on Repair Discoveries (ICORD), The University of British Columbia, Vancouver, BC, Canada
– sequence: 9
  givenname: Alex L
  surname: MacKay
  fullname: MacKay, Alex L
  organization: Department of Radiology, The University of British Columbia, Vancouver, BC, Canada; Department of Physics and Astronomy, The University of British Columbia, Vancouver, BC, Canada
– sequence: 10
  givenname: Cornelia
  surname: Laule
  fullname: Laule, Cornelia
  organization: Department of Radiology, The University of British Columbia, Vancouver, BC, Canada/Department of Pathology and Laboratory Medicine, The University of British Columbia, Vancouver, BC, Canada/International Collaboration on Repair Discoveries (ICORD), The University of British Columbia, Vancouver, BC, Canada
BackLink https://www.ncbi.nlm.nih.gov/pubmed/28782447$$D View this record in MEDLINE/PubMed
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Issue 12
Keywords normal-appearing white matter
Multiple sclerosis
myelin water fraction
longitudinal
Language English
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Snippet Reduced myelin water fraction (MWF, a marker for myelin), increased geometric mean T (ieGMT , reflecting intra/extracellular water properties), and increased T...
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Title Global loss of myelin water over 5 years in multiple sclerosis normal-appearing white matter
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