Journey of siRNA: Clinical Developments and Targeted Delivery

• Published in: Nucleic acid therapeutics Vol. 28; no. 4; pp. 29 - 224
• Main Authors: Nikam, Rahul R., Gore, Kiran R.
• Format: Journal Article
• Language: English
• Published: United States Mary Ann Liebert, Inc 01.08.2018
• Subjects: Biological evolution; Cancer; Chemical compounds; Clinical trials; Conjugation; Drug development; Enzymes; Gene expression; Gene silencing; Glaucoma; Hypertension; Infections; Ligands; Macular degeneration; Medical research; Pain; Peptides; Pharmaceuticals; Pharmacology; Proteins; Review; Reviews; Ribonucleic acid; RNA; RNA-mediated interference; siRNA; Vascular endothelial growth factor; Mumbai India; India; clinical trial; gene silencing; targeted delivery; siRNA; RNA interference; GalNAc

Since the evolutionary discovery of RNA interference and its utilization for gene knockdown in mammalian cell, a remarkable progress has been achieved in small interfering RNA (siRNA) therapeutics. siRNA is a promising tool, utilized as therapeutic agent against various diseases. Despite its signifi...