High polygenic burden is associated with blood DNA methylation changes in individuals with suicidal behavior

• Published in: Journal of psychiatric research Vol. 123; pp. 62 - 71
• Main Authors: Cabrera-Mendoza, Brenda, Martínez-Magaña, José Jaime, Genis-Mendoza, Alma Delia, Sarmiento, Emmanuel, Ruíz-Ramos, David, Tovilla-Zárate, Carlos Alfonso, González-Castro, Thelma Beatriz, Juárez-Rojop, Isela Esther, García-de la Cruz, Dulce Dajheanne, López-Armenta, Mauro, Real, Fernanda, García-Dolores, Fernando, Flores, Gonzalo, Vázquez-Roque, Rubén Antonio, Lanzagorta, Nuria, Escamilla, Michael, Saucedo‐Uribe, Erasmo, Rodríguez-Mayoral, Oscar, Jiménez-Genchi, Janet, Castañeda-González, Carlos, Roche-Bergua, Andrés, Nicolini, Humberto
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2020
• Subjects: DNA Methylation; Epigenesis, Genetic; Epigenomics; Genetics; Humans; Multifactorial Inheritance; Polygenic risk score (PRS); Suicidal Ideation; Suicide; Suicide, Attempted; DNA methylation; Genetics; Polygenic risk score (PRS); Epigenomics; Suicide; Multifactorial inheritance

Suicidal behavior is result of the interaction of several contributors, including genetic and environmental factors. The integration of approaches considering the polygenic component of suicidal behavior, such as polygenic risk scores (PRS) and DNA methylation is promising for improving our understa...