SPE–UPLC–MS/MS method for sensitive and rapid determination of aripiprazole in human plasma to support a bioequivalence study

• Published in: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Vol. 925; pp. 20 - 25
• Main Authors: Patel, Daxesh P., Sharma, Primal, Sanyal, Mallika, Shrivastav, Pranav S.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.04.2013
• Subjects: Aripiprazole; Aripiprazole-d8; Bioequivalence; Chromatography; Chromatography, High Pressure Liquid - methods; Extraction; Formates; Human; Human plasma; Humans; Ionization; Linear Models; Linearity; Mathematical analysis; methanol; Methyl alcohol; monitoring; pharmacokinetics; Piperazines - blood; Piperazines - chemistry; Piperazines - pharmacokinetics; Quinolones - blood; Quinolones - chemistry; Quinolones - pharmacokinetics; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction - methods; Solid-phase extraction; storage conditions; Tandem Mass Spectrometry - methods; Therapeutic Equivalency; UPLC–MS/MS; Aripiprazole-d8; Human plasma; Bioequivalence; Aripiprazole; UPLC–MS/MS; Solid-phase extraction

► An improved UPLC–MS/MS method for determination of aripiprazole in human plasma. ► Highly sensitive and rapid compared to all existing methods in biological matrices. ► Practically free from endogenous matrix interference. ► Successful bioequivalence study in healthy Indian subjects. ► Reproducibi...