Targeting sialic acid–Siglec interactions to reverse immune suppression in cancer

Abstract Changes in sialic acids in cancer have been observed for many years. In particular, the increase of sialoglycan density or hypersialylation in tumors has been described. Recent studies have identified mechanisms for immune evasion based on sialoglycan interactions with immunoregulatory Sigl...

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Published inGlycobiology (Oxford) Vol. 28; no. 9; pp. 640 - 647
Main Authors Adams, Olivia Joan, Stanczak, Michal A, von Gunten, Stephan, Läubli, Heinz
Format Journal Article
LanguageEnglish
Published England Oxford University Press 01.09.2018
Subjects
Humans
Immune Tolerance - immunology
Immunity, Innate
Immunotherapy
N-Acetylneuraminic Acid - immunology
Neoplasms - immunology
Neoplasms - therapy
Sialic Acid Binding Immunoglobulin-like Lectins - immunology
blocking antibodies
acetyl-neuraminic acid
immune evasion
glycolyl-neuraminic acid
hypersialylation
cancer immunotherapy
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Abstract Abstract Changes in sialic acids in cancer have been observed for many years. In particular, the increase of sialoglycan density or hypersialylation in tumors has been described. Recent studies have identified mechanisms for immune evasion based on sialoglycan interactions with immunoregulatory Siglec receptors that are exploited by tumor cells and microorganisms alike. Siglecs are mostly inhibitory receptors similar to known immune checkpoints including PD-1 or CTLA-4 that are successfully targeted with blocking antibodies for cancer immunotherapy. Here, we summarize the known changes of sialic acids in cancer and the role Siglec receptors play in cancer immunity. We also focus on potential ways to target these Siglec receptors or sialoglycans in order to improve anti-cancer immunity.
AbstractList Changes in sialic acids in cancer have been observed for many years. In particular, the increase of sialoglycan density or hypersialylation in tumors has been described. Recent studies have identified mechanisms for immune evasion based on sialoglycan interactions with immunoregulatory Siglec receptors that are exploited by tumor cells and microorganisms alike. Siglecs are mostly inhibitory receptors similar to known immune checkpoints including PD-1 or CTLA-4 that are successfully targeted with blocking antibodies for cancer immunotherapy. Here, we summarize the known changes of sialic acids in cancer and the role Siglec receptors play in cancer immunity. We also focus on potential ways to target these Siglec receptors or sialoglycans in order to improve anti-cancer immunity.
Abstract Changes in sialic acids in cancer have been observed for many years. In particular, the increase of sialoglycan density or hypersialylation in tumors has been described. Recent studies have identified mechanisms for immune evasion based on sialoglycan interactions with immunoregulatory Siglec receptors that are exploited by tumor cells and microorganisms alike. Siglecs are mostly inhibitory receptors similar to known immune checkpoints including PD-1 or CTLA-4 that are successfully targeted with blocking antibodies for cancer immunotherapy. Here, we summarize the known changes of sialic acids in cancer and the role Siglec receptors play in cancer immunity. We also focus on potential ways to target these Siglec receptors or sialoglycans in order to improve anti-cancer immunity.
Author Stanczak, Michal A
von Gunten, Stephan
Adams, Olivia Joan
Läubli, Heinz
Author_xml – sequence: 1
  givenname: Olivia Joan
  surname: Adams
  fullname: Adams, Olivia Joan
  organization: Institute of Pharmacology, University of Bern, Inselspital INO-F, Bern, Switzerland
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  givenname: Michal A
  surname: Stanczak
  fullname: Stanczak, Michal A
  organization: Laboratory of Cancer Immunology, Department of Biomedicine
– sequence: 3
  givenname: Stephan
  surname: von Gunten
  fullname: von Gunten, Stephan
  email: stephan.vongunten@pki.unibe.ch
  organization: Institute of Pharmacology, University of Bern, Inselspital INO-F, Bern, Switzerland
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  givenname: Heinz
  surname: Läubli
  fullname: Läubli, Heinz
  email: heinz.laeubli@unibas.ch
  organization: Laboratory of Cancer Immunology, Department of Biomedicine
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Cites_doi 10.1016/j.immuni.2011.10.014
10.1074/jbc.M114.574624
10.1182/blood-2014-08-596403
10.1073/pnas.1608069113
10.1074/jbc.M113.523753
10.1038/bjc.1968.99
10.4049/jimmunol.181.9.6625
10.1016/j.cell.2015.03.030
10.1007/s00018-014-1799-5
10.1126/scitranslmed.3010524
10.1093/glycob/cwr087
10.1182/blood-2004-10-4112
10.1021/nn5061964
10.1007/s11030-006-9029-1
10.1016/j.bcp.2011.05.018
10.1007/s00109-015-1341-8
10.1182/blood-2009-12-257386
10.3389/fimmu.2017.00314
10.1016/j.immuni.2012.03.004
10.1111/j.1349-7006.2009.01455.x
10.1038/nri3737
10.1016/j.ccell.2015.03.001
10.1016/S1521-6616(03)00036-6
10.1074/jbc.273.42.27199
10.1158/0008-5472.CAN-14-0728
10.1038/ni.3535
10.1073/pnas.0404833101
10.1093/glycob/cwu044
10.1182/blood-2006-05-021568
10.4049/jimmunol.1700898
10.1126/science.1168988
10.1007/s10719-006-6734-z
10.1007/s10719-008-9183-z
10.1038/nchembio.1388
10.1016/j.mam.2016.07.002
10.1084/jem.20030635
10.1002/eji.200323693
10.1097/00007890-196709000-00005
10.1073/pnas.1409580111
10.1016/S0300-9084(01)01303-7
10.1038/nrc3982
10.7554/eLife.06184
10.1093/glycob/cwv051
10.1182/blood-2012-08-449983
10.1084/jem.20131853
10.1111/j.1749-6632.2011.06304.x
10.4049/jimmunol.168.5.2523
10.1038/s41467-017-00836-6
10.1073/pnas.1219888110
10.1016/j.bbagen.2014.06.006
10.1016/j.cell.2013.01.011
10.1016/j.carres.2014.02.004
10.1074/jbc.M111.243410
10.1007/s00253-012-4040-1
10.18632/oncotarget.9419
10.3389/fimmu.2014.00325
10.1074/jbc.M604221200
10.1096/fj.13-241497
10.15252/embj.201695581
10.1007/s10555-012-9359-7
10.1200/JCO.2012.43.0132
10.1007/BF00749902
10.1074/jbc.M114.593129
10.1046/j.1432-1033.2003.03927.x
10.1146/annurev.iy.02.040184.000535
10.18632/oncotarget.6822
10.3109/10428194.2011.604755
10.1073/pnas.2131556100
10.1097/ACI.0000000000000234
10.1002/ijc.2910150307
10.1073/pnas.1417508112
10.1023/A:1011062223612
10.1084/jem.20090691
10.1093/glycob/cwx026
10.1093/glycob/cwu067
10.1038/ni.3552
10.1038/ni.2610
10.1007/978-3-319-11280-0_1
10.1074/jbc.M115.691337
10.3389/fonc.2012.00170
10.1093/glycob/cwp063
10.1073/pnas.1507706113
10.1038/nrc1649
10.1172/JCI65899
10.1074/jbc.M116.738351
10.1196/annals.1443.011
10.1038/nri2056
10.1023/A:1007026314792
10.1093/glycob/cwv097
10.1182/blood-2008-11-187302
10.1111/j.1365-2567.2010.03368.x
10.1111/imr.12526
10.1146/annurev-immunol-020711-075018
10.1074/jbc.M001123200
10.1073/pnas.0803943105
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Issue 9
Keywords blocking antibodies
acetyl-neuraminic acid
immune evasion
glycolyl-neuraminic acid
hypersialylation
cancer immunotherapy
Language English
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References Chen ( key 20180328170405_cwx108C22) 2012; 53
Läubli ( key 20180328170405_cwx108C49) 2014; 111
Padler-Karavani ( key 20180328170405_cwx108C61) 2014; 28
Diaz ( key 20180328170405_cwx108C29) 2003; 107
Li ( key 20180328170405_cwx108C50) 2012; 94
Perdicchio ( key 20180328170405_cwx108C63) 2016; 7
Tachibana ( key 20180328170405_cwx108C86) 1994; 16
Pearce ( key 20180328170405_cwx108C62) 2016; 26
Läubli ( key 20180328170405_cwx108C48) 2014; 289
Schwarz ( key 20180328170405_cwx108C77) 2015; 842
Alfonso ( key 20180328170405_cwx108C1) 2002; 168
Naito-Matsui ( key 20180328170405_cwx108C59) 2014; 289
Amon ( key 20180328170405_cwx108C5) 2014; 389
Rabinovich ( key 20180328170405_cwx108C67) 2012; 36
Varki ( key 20180328170405_cwx108C93) 2011; 21
Sanford ( key 20180328170405_cwx108C72) 1967; 5
Boligan ( key 20180328170405_cwx108C12) 2015; 72
Fraschilla ( key 20180328170405_cwx108C33) 2017; 276
von Gunten ( key 20180328170405_cwx108C97) 2006; 108
Berger ( key 20180328170405_cwx108C11) 1969; 75
Schwarz ( key 20180328170405_cwx108C78) 2017; 36
Angata ( key 20180328170405_cwx108C6) 2006; 10
Sedlacek ( key 20180328170405_cwx108C81) 1975; 15
Carlin ( key 20180328170405_cwx108C17) 2009; 206
Clark ( key 20180328170405_cwx108C24) 2012; 1253
Schultz ( key 20180328170405_cwx108C76) 2012; 31
Beatson ( key 20180328170405_cwx108C9) 2016; 17
Silva ( key 20180328170405_cwx108C85) 2016; 7
Kawasaki ( key 20180328170405_cwx108C46) 2013; 110
Alisson-Silva ( key 20180328170405_cwx108C3) 2016; 51
Ereno-Orbea ( key 20180328170405_cwx108C31) 2017; 8
Secundino ( key 20180328170405_cwx108C80) 2015; 94
Jabbour ( key 20180328170405_cwx108C41) 2015; 125
Ding ( key 20180328170405_cwx108C30) 2016; 17
Büll ( key 20180328170405_cwx108C14) 2015; 9
Angata ( key 20180328170405_cwx108C7) 2004; 101
Chen ( key 20180328170405_cwx108C20) 2010; 115
Macauley ( key 20180328170405_cwx108C52) 2014; 14
Hedlund ( key 20180328170405_cwx108C37) 2008; 105
Crocker ( key 20180328170405_cwx108C26) 2007; 7
Schleimer ( key 20180328170405_cwx108C74) 2016; 16
Go ( key 20180328170405_cwx108C35) 2006; 23
Bandala-Sanchez ( key 20180328170405_cwx108C8) 2013; 14
Bednar ( key 20180328170405_cwx108C10) 2017; 199
Inoue ( key 20180328170405_cwx108C40) 1998; 273
Ali ( key 20180328170405_cwx108C2) 2014; 211
Fuster ( key 20180328170405_cwx108C34) 2005; 5
Fedarko ( key 20180328170405_cwx108C32) 2000; 275
Hernandez ( key 20180328170405_cwx108C38) 2008; 181
Yu ( key 20180328170405_cwx108C101) 2017; 27
Mikulak ( key 20180328170405_cwx108C57) 2017; 8
Pinho ( key 20180328170405_cwx108C66) 2015; 15
Dall’Olio ( key 20180328170405_cwx108C28) 2014; 1840
Borys ( key 20180328170405_cwx108C13) 1993; 11
Hudak ( key 20180328170405_cwx108C39) 2014; 10
Hakomori ( key 20180328170405_cwx108C36) 1984; 2
Chen ( key 20180328170405_cwx108C21) 2013; 152
Pillai ( key 20180328170405_cwx108C65) 2012; 30
Sharma ( key 20180328170405_cwx108C82) 2015; 161
Corfield ( key 20180328170405_cwx108C25) 1999; 16
McMillan ( key 20180328170405_cwx108C55) 2013; 121
Büll ( key 20180328170405_cwx108C15) 2014; 74
Malykh ( key 20180328170405_cwx108C54) 2001; 83
Nagamune ( key 20180328170405_cwx108C58) 2004; 199
Topalian ( key 20180328170405_cwx108C89) 2015; 27
Wang ( key 20180328170405_cwx108C99) 2015; 25
Perdicchio ( key 20180328170405_cwx108C64) 2016; 113
Schneider ( key 20180328170405_cwx108C75) 2015; 7
Siddiqui ( key 20180328170405_cwx108C84) 2017; 292
Takagi ( key 20180328170405_cwx108C87) 2011; 35
Varki ( key 20180328170405_cwx108C92) 2009; 19
Jandus ( key 20180328170405_cwx108C43) 2014; 124
Nicoll ( key 20180328170405_cwx108C60) 2003; 33
Currie ( key 20180328170405_cwx108C27) 1968; 22
Urbanitz ( key 20180328170405_cwx108C90) 1987; 30
Carlin ( key 20180328170405_cwx108C18) 2009; 113
Krengel ( key 20180328170405_cwx108C47) 2014; 5
von Gunten ( key 20180328170405_cwx108C96) 2008; 1143
Xiao ( key 20180328170405_cwx108C100) 2016; 113
Linnartz-Gerlach ( key 20180328170405_cwx108C51) 2014; 24
Samraj ( key 20180328170405_cwx108C70) 2014; 4
Jabbour ( key 20180328170405_cwx108C42) 2017
Samraj ( key 20180328170405_cwx108C71) 2015; 112
Varki ( key 20180328170405_cwx108C91) 2009; 26
Schauer ( key 20180328170405_cwx108C73) 2000; 17
Vazquez ( key 20180328170405_cwx108C95) 2012; 2
Cao ( key 20180328170405_cwx108C16) 2011; 132
Altheide ( key 20180328170405_cwx108C4) 2006; 281
Shen ( key 20180328170405_cwx108C83) 2004; 271
Varki ( key 20180328170405_cwx108C94) 2015
Schwarz ( key 20180328170405_cwx108C79) 2015; 4
Tangvoranuntakul ( key 20180328170405_cwx108C88) 2003; 100
Macauley ( key 20180328170405_cwx108C53) 2015; 290
Jandus ( key 20180328170405_cwx108C44) 2011; 82
McMillan ( key 20180328170405_cwx108C56) 2014; 289
Ravandi ( key 20180328170405_cwx108C68) 2012; 30
Redelinghuys ( key 20180328170405_cwx108C69) 2011; 286
Chen ( key 20180328170405_cwx108C23) 2009; 323
von Gunten ( key 20180328170405_cwx108C98) 2005; 106
Kannagi ( key 20180328170405_cwx108C45) 2010; 101
Chang ( key 20180328170405_cwx108C19) 2014; 24
References_xml – volume: 35
  start-page: 958
  year: 2011
  ident: key 20180328170405_cwx108C87
  article-title: Plasmacytoid dendritic cells are crucial for the initiation of inflammation and T cell immunity in vivo
  publication-title: Immunity
  doi: 10.1016/j.immuni.2011.10.014
  contributor:
    fullname: Takagi
– volume: 289
  start-page: 20370
  year: 2014
  ident: key 20180328170405_cwx108C56
  article-title: Siglec-E promotes beta2-integrin-dependent NADPH oxidase activation to suppress neutrophil recruitment to the lung
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M114.574624
  contributor:
    fullname: McMillan
– volume: 4
  start-page: 33
  year: 2014
  ident: key 20180328170405_cwx108C70
  article-title: Involvement of a non-human sialic acid in human cancer
  publication-title: Front Oncol
  contributor:
    fullname: Samraj
– volume: 125
  start-page: 4010
  year: 2015
  ident: key 20180328170405_cwx108C41
  article-title: Monoclonal antibodies in acute lymphoblastic leukemia
  publication-title: Blood
  doi: 10.1182/blood-2014-08-596403
  contributor:
    fullname: Jabbour
– volume: 113
  start-page: 10304
  year: 2016
  ident: key 20180328170405_cwx108C100
  article-title: Precision glycocalyx editing as a strategy for cancer immunotherapy
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1608069113
  contributor:
    fullname: Xiao
– volume: 289
  start-page: 1564
  year: 2014
  ident: key 20180328170405_cwx108C59
  article-title: Functional evaluation of activation-dependent alterations in the sialoglycan composition of T cells
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M113.523753
  contributor:
    fullname: Naito-Matsui
– volume: 22
  start-page: 843
  year: 1968
  ident: key 20180328170405_cwx108C27
  article-title: The role of sialic acid in antigenic expression: Further studies of the Landschutz ascites tumour
  publication-title: Br J Cancer
  doi: 10.1038/bjc.1968.99
  contributor:
    fullname: Currie
– volume: 181
  start-page: 6625
  year: 2008
  ident: key 20180328170405_cwx108C38
  article-title: Characterization of the antibody response against NeuGcGM3 ganglioside elicited in non-small cell lung cancer patients immunized with an anti-idiotype antibody
  publication-title: J Immunol
  doi: 10.4049/jimmunol.181.9.6625
  contributor:
    fullname: Hernandez
– volume: 161
  start-page: 205
  year: 2015
  ident: key 20180328170405_cwx108C82
  article-title: Immune checkpoint targeting in cancer therapy: Toward combination strategies with curative potential
  publication-title: Cell
  doi: 10.1016/j.cell.2015.03.030
  contributor:
    fullname: Sharma
– volume: 72
  start-page: 1231
  year: 2015
  ident: key 20180328170405_cwx108C12
  article-title: Cancer intelligence acquired (CIA): Tumor glycosylation and sialylation codes dismantling antitumor defense
  publication-title: Cell Mol Life Sci
  doi: 10.1007/s00018-014-1799-5
  contributor:
    fullname: Boligan
– volume: 7
  start-page: 269ra261
  year: 2015
  ident: key 20180328170405_cwx108C75
  article-title: The human IgG anti-carbohydrate repertoire exhibits a universal architecture and contains specificity for microbial attachment sites
  publication-title: Sci Transl Med
  doi: 10.1126/scitranslmed.3010524
  contributor:
    fullname: Schneider
– volume: 21
  start-page: 1121
  year: 2011
  ident: key 20180328170405_cwx108C93
  article-title: Since there are PAMPs and DAMPs, there must be SAMPs? Glycan “self-associated molecular patterns” dampen innate immunity, but pathogens can mimic them
  publication-title: Glycobiology
  doi: 10.1093/glycob/cwr087
  contributor:
    fullname: Varki
– volume: 106
  start-page: 1423
  year: 2005
  ident: key 20180328170405_cwx108C98
  article-title: Siglec-9 transduces apoptotic and nonapoptotic death signals into neutrophils depending on the proinflammatory cytokine environment
  publication-title: Blood
  doi: 10.1182/blood-2004-10-4112
  contributor:
    fullname: von Gunten
– volume: 9
  start-page: 733
  year: 2015
  ident: key 20180328170405_cwx108C14
  article-title: Targeted delivery of a sialic acid-blocking glycomimetic to cancer cells inhibits metastatic spread
  publication-title: ACS Nano
  doi: 10.1021/nn5061964
  contributor:
    fullname: Büll
– volume: 10
  start-page: 555
  year: 2006
  ident: key 20180328170405_cwx108C6
  article-title: Molecular diversity and evolution of the Siglec family of cell-surface lectins
  publication-title: Mol Divers
  doi: 10.1007/s11030-006-9029-1
  contributor:
    fullname: Angata
– volume: 82
  start-page: 323
  year: 2011
  ident: key 20180328170405_cwx108C44
  article-title: Targeting siglecs – a novel pharmacological strategy for immuno- and glycotherapy
  publication-title: Biochem Pharmacol
  doi: 10.1016/j.bcp.2011.05.018
  contributor:
    fullname: Jandus
– volume: 94
  start-page: 219
  issue: 2
  year: 2015
  ident: key 20180328170405_cwx108C80
  article-title: Host and pathogen hyaluronan signal through human siglec-9 to suppress neutrophil activation
  publication-title: J Mol Med (Berl)
  doi: 10.1007/s00109-015-1341-8
  contributor:
    fullname: Secundino
– volume: 115
  start-page: 4778
  year: 2010
  ident: key 20180328170405_cwx108C20
  article-title: In vivo targeting of B-cell lymphoma with glycan ligands of CD22
  publication-title: Blood
  doi: 10.1182/blood-2009-12-257386
  contributor:
    fullname: Chen
– volume: 8
  start-page: 314
  year: 2017
  ident: key 20180328170405_cwx108C57
  article-title: Host immune responses in HIV-1 infection: The emerging pathogenic role of siglecs and their clinical correlates
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2017.00314
  contributor:
    fullname: Mikulak
– volume: 36
  start-page: 322
  year: 2012
  ident: key 20180328170405_cwx108C67
  article-title: Regulatory circuits mediated by lectin-glycan interactions in autoimmunity and cancer
  publication-title: Immunity
  doi: 10.1016/j.immuni.2012.03.004
  contributor:
    fullname: Rabinovich
– volume: 101
  start-page: 586
  year: 2010
  ident: key 20180328170405_cwx108C45
  article-title: Altered expression of glycan genes in cancers induced by epigenetic silencing and tumor hypoxia: Clues in the ongoing search for new tumor markers
  publication-title: Cancer Sci
  doi: 10.1111/j.1349-7006.2009.01455.x
  contributor:
    fullname: Kannagi
– volume: 14
  start-page: 653
  year: 2014
  ident: key 20180328170405_cwx108C52
  article-title: Siglec-mediated regulation of immune cell function in disease
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri3737
  contributor:
    fullname: Macauley
– volume: 75
  start-page: 269
  year: 1969
  ident: key 20180328170405_cwx108C11
  article-title: Application of immunofluorescence to renal pathology. II. Immunohistochemical study of glomerular lesions
  publication-title: J Urol Nephrol (Paris)
  contributor:
    fullname: Berger
– volume: 27
  start-page: 450
  year: 2015
  ident: key 20180328170405_cwx108C89
  article-title: Immune checkpoint blockade: A common denominator approach to cancer therapy
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2015.03.001
  contributor:
    fullname: Topalian
– volume: 107
  start-page: 80
  year: 2003
  ident: key 20180328170405_cwx108C29
  article-title: Immune responses in breast cancer patients immunized with an anti-idiotype antibody mimicking NeuGc-containing gangliosides
  publication-title: Clin Immunol
  doi: 10.1016/S1521-6616(03)00036-6
  contributor:
    fullname: Diaz
– volume: 273
  start-page: 27199
  year: 1998
  ident: key 20180328170405_cwx108C40
  article-title: Identification of free deaminated sialic acid (2-keto-3-deoxy-D-glycero-D-galacto-nononic acid) in human red blood cells and its elevated expression in fetal cord red blood cells and ovarian cancer cells
  publication-title: J Biol Chem
  doi: 10.1074/jbc.273.42.27199
  contributor:
    fullname: Inoue
– volume: 74
  start-page: 3199
  year: 2014
  ident: key 20180328170405_cwx108C15
  article-title: Sialic acids sweeten a tumor’s life
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-14-0728
  contributor:
    fullname: Büll
– volume: 17
  start-page: 1167
  year: 2016
  ident: key 20180328170405_cwx108C30
  article-title: The lectin Siglec-G inhibits dendritic cell cross-presentation by impairing MHC class I-peptide complex formation
  publication-title: Nat Immunol
  doi: 10.1038/ni.3535
  contributor:
    fullname: Ding
– volume: 101
  start-page: 13251
  year: 2004
  ident: key 20180328170405_cwx108C7
  article-title: Large-scale sequencing of the CD33-related Siglec gene cluster in five mammalian species reveals rapid evolution by multiple mechanisms
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0404833101
  contributor:
    fullname: Angata
– volume: 24
  start-page: 794
  year: 2014
  ident: key 20180328170405_cwx108C51
  article-title: Siglec functions of microglia
  publication-title: Glycobiology
  doi: 10.1093/glycob/cwu044
  contributor:
    fullname: Linnartz-Gerlach
– volume-title: Essentials of Glycobiology
  year: 2015
  ident: key 20180328170405_cwx108C94
  contributor:
    fullname: Varki
– volume: 108
  start-page: 4255
  year: 2006
  ident: key 20180328170405_cwx108C97
  article-title: Immunologic and functional evidence for anti-Siglec-9 autoantibodies in intravenous immunoglobulin preparations
  publication-title: Blood
  doi: 10.1182/blood-2006-05-021568
  contributor:
    fullname: von Gunten
– volume: 199
  start-page: 3116
  year: 2017
  ident: key 20180328170405_cwx108C10
  article-title: Human CD22 inhibits murine B cell receptor activation in a human CD22 transgenic mouse model
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1700898
  contributor:
    fullname: Bednar
– volume: 323
  start-page: 1722
  year: 2009
  ident: key 20180328170405_cwx108C23
  article-title: CD24 and Siglec-10 selectively repress tissue damage-induced immune responses
  publication-title: Science
  doi: 10.1126/science.1168988
  contributor:
    fullname: Chen
– volume: 23
  start-page: 411
  year: 2006
  ident: key 20180328170405_cwx108C35
  article-title: Oral ingestion of mannose alters the expression level of deaminoneuraminic acid (KDN) in mouse organs
  publication-title: Glycoconj J
  doi: 10.1007/s10719-006-6734-z
  contributor:
    fullname: Go
– volume: 26
  start-page: 231
  year: 2009
  ident: key 20180328170405_cwx108C91
  article-title: Multiple changes in sialic acid biology during human evolution
  publication-title: Glycoconj J
  doi: 10.1007/s10719-008-9183-z
  contributor:
    fullname: Varki
– volume: 10
  start-page: 69
  year: 2014
  ident: key 20180328170405_cwx108C39
  article-title: Glycocalyx engineering reveals a Siglec-based mechanism for NK cell immunoevasion
  publication-title: Nat Chem Biol
  doi: 10.1038/nchembio.1388
  contributor:
    fullname: Hudak
– volume: 51
  start-page: 16
  year: 2016
  ident: key 20180328170405_cwx108C3
  article-title: Human risk of diseases associated with red meat intake: Analysis of current theories and proposed role for metabolic incorporation of a non-human sialic acid
  publication-title: Mol Aspects Med
  doi: 10.1016/j.mam.2016.07.002
  contributor:
    fullname: Alisson-Silva
– volume: 199
  start-page: 1445
  year: 2004
  ident: key 20180328170405_cwx108C58
  article-title: Surface sialic acids taken from the host allow trypanosome survival in tsetse fly vectors
  publication-title: J Exp Med
  doi: 10.1084/jem.20030635
  contributor:
    fullname: Nagamune
– volume: 33
  start-page: 1642
  year: 2003
  ident: key 20180328170405_cwx108C60
  article-title: Ganglioside GD3 expression on target cells can modulate NK cell cytotoxicity via siglec-7-dependent and -independent mechanisms
  publication-title: Eur J Immunol
  doi: 10.1002/eji.200323693
  contributor:
    fullname: Nicoll
– volume: 5
  start-page: 1273
  year: 1967
  ident: key 20180328170405_cwx108C72
  article-title: An alteration in tumor histocompatibility induced by neuraminidase
  publication-title: Transplantation
  doi: 10.1097/00007890-196709000-00005
  contributor:
    fullname: Sanford
– volume: 111
  start-page: 14211
  year: 2014
  ident: key 20180328170405_cwx108C49
  article-title: Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1409580111
  contributor:
    fullname: Läubli
– volume: 83
  start-page: 623
  year: 2001
  ident: key 20180328170405_cwx108C54
  article-title: N-glycolylneuraminic acid in human tumours
  publication-title: Biochimie
  doi: 10.1016/S0300-9084(01)01303-7
  contributor:
    fullname: Malykh
– year: 2017
  ident: key 20180328170405_cwx108C42
  article-title: Salvage chemoimmunotherapy with inotuzumab ozogamicin combined with mini-hyper-CVD for patients with relapsed or refractory philadelphia chromosome-negative acute lymphoblastic leukemia: A Phase 2 Clinical Trial
  publication-title: JAMA Oncol
  contributor:
    fullname: Jabbour
– volume: 15
  start-page: 540
  year: 2015
  ident: key 20180328170405_cwx108C66
  article-title: Glycosylation in cancer: Mechanisms and clinical implications
  publication-title: Nat Rev Cancer
  doi: 10.1038/nrc3982
  contributor:
    fullname: Pinho
– volume: 4
  start-page: e06184
  year: 2015
  ident: key 20180328170405_cwx108C79
  article-title: Siglec receptors impact mammalian lifespan by modulating oxidative stress
  publication-title: Elife
  doi: 10.7554/eLife.06184
  contributor:
    fullname: Schwarz
– volume: 25
  start-page: 1362
  year: 2015
  ident: key 20180328170405_cwx108C99
  article-title: LC-MS/MS glycomic analyses of free and conjugated forms of the sialic acids, Neu5Ac, Neu5Gc and KDN in human throat cancers
  publication-title: Glycobiology
  doi: 10.1093/glycob/cwv051
  contributor:
    fullname: Wang
– volume: 121
  start-page: 2084
  year: 2013
  ident: key 20180328170405_cwx108C55
  article-title: Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b beta2-integrin-dependent signaling
  publication-title: Blood
  doi: 10.1182/blood-2012-08-449983
  contributor:
    fullname: McMillan
– volume: 211
  start-page: 1231
  year: 2014
  ident: key 20180328170405_cwx108C2
  article-title: Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus
  publication-title: J Exp Med
  doi: 10.1084/jem.20131853
  contributor:
    fullname: Ali
– volume: 1253
  start-page: 58
  year: 2012
  ident: key 20180328170405_cwx108C24
  article-title: T cells modulate glycans on CD43 and CD45 during development and activation, signal regulation, and survival
  publication-title: Ann N Y Acad Sci
  doi: 10.1111/j.1749-6632.2011.06304.x
  contributor:
    fullname: Clark
– volume: 168
  start-page: 2523
  year: 2002
  ident: key 20180328170405_cwx108C1
  article-title: An anti-idiotype vaccine elicits a specific response to N-glycolyl sialic acid residues of glycoconjugates in melanoma patients
  publication-title: J Immunol
  doi: 10.4049/jimmunol.168.5.2523
  contributor:
    fullname: Alfonso
– volume: 8
  start-page: 764
  year: 2017
  ident: key 20180328170405_cwx108C31
  article-title: Molecular basis of human CD22 function and therapeutic targeting
  publication-title: Nat Commun
  doi: 10.1038/s41467-017-00836-6
  contributor:
    fullname: Ereno-Orbea
– volume: 110
  start-page: 7826
  year: 2013
  ident: key 20180328170405_cwx108C46
  article-title: Targeted delivery of lipid antigen to macrophages via the CD169/sialoadhesin endocytic pathway induces robust invariant natural killer T cell activation
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1219888110
  contributor:
    fullname: Kawasaki
– volume: 1840
  start-page: 2752
  year: 2014
  ident: key 20180328170405_cwx108C28
  article-title: Sialosignaling: Sialyltransferases as engines of self-fueling loops in cancer progression
  publication-title: Biochim Biophys Acta
  doi: 10.1016/j.bbagen.2014.06.006
  contributor:
    fullname: Dall’Olio
– volume: 152
  start-page: 467
  year: 2013
  ident: key 20180328170405_cwx108C21
  article-title: Induction of Siglec-G by RNA viruses inhibits the innate immune response by promoting RIG-I degradation
  publication-title: Cell
  doi: 10.1016/j.cell.2013.01.011
  contributor:
    fullname: Chen
– volume: 389
  start-page: 115
  year: 2014
  ident: key 20180328170405_cwx108C5
  article-title: Glycans in immune recognition and response
  publication-title: Carbohydr Res
  doi: 10.1016/j.carres.2014.02.004
  contributor:
    fullname: Amon
– volume: 286
  start-page: 34522
  year: 2011
  ident: key 20180328170405_cwx108C69
  article-title: Early murine T-lymphocyte activation is accompanied by a switch from N-Glycolyl- to N-acetyl-neuraminic acid and generation of ligands for siglec-E
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M111.243410
  contributor:
    fullname: Redelinghuys
– volume: 94
  start-page: 887
  year: 2012
  ident: key 20180328170405_cwx108C50
  article-title: Sialic acid metabolism and sialyltransferases: Natural functions and applications
  publication-title: Appl Microbiol Biotechnol
  doi: 10.1007/s00253-012-4040-1
  contributor:
    fullname: Li
– volume: 7
  start-page: 41053
  year: 2016
  ident: key 20180328170405_cwx108C85
  article-title: Sialic acid removal from dendritic cells improves antigen cross-presentation and boosts anti-tumor immune responses
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.9419
  contributor:
    fullname: Silva
– volume: 5
  start-page: 325
  year: 2014
  ident: key 20180328170405_cwx108C47
  article-title: Molecular recognition of gangliosides and their potential for cancer immunotherapies
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2014.00325
  contributor:
    fullname: Krengel
– volume: 281
  start-page: 25689
  year: 2006
  ident: key 20180328170405_cwx108C4
  article-title: System-wide genomic and biochemical comparisons of sialic acid biology among primates and rodents: Evidence for two modes of rapid evolution
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M604221200
  contributor:
    fullname: Altheide
– volume: 28
  start-page: 1280
  year: 2014
  ident: key 20180328170405_cwx108C61
  article-title: Rapid evolution of binding specificities and expression patterns of inhibitory CD33-related Siglecs in primates
  publication-title: FASEB J
  doi: 10.1096/fj.13-241497
  contributor:
    fullname: Padler-Karavani
– volume: 36
  start-page: 751
  year: 2017
  ident: key 20180328170405_cwx108C78
  article-title: Paired Siglec receptors generate opposite inflammatory responses to a human-specific pathogen
  publication-title: EMBO J
  doi: 10.15252/embj.201695581
  contributor:
    fullname: Schwarz
– volume: 30
  start-page: 64
  year: 1987
  ident: key 20180328170405_cwx108C90
  article-title: Neuraminidase-treated allogeneic blasts for maintenance in acute myelogenous leukemia: Results of a prospective randomized trial
  publication-title: Haematol Blood Transfus
  contributor:
    fullname: Urbanitz
– volume: 31
  start-page: 501
  year: 2012
  ident: key 20180328170405_cwx108C76
  article-title: Regulation of the metastatic cell phenotype by sialylated glycans
  publication-title: Cancer Metastasis Rev
  doi: 10.1007/s10555-012-9359-7
  contributor:
    fullname: Schultz
– volume: 30
  start-page: 3921
  year: 2012
  ident: key 20180328170405_cwx108C68
  article-title: Gemtuzumab ozogamicin: Time to resurrect?
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.2012.43.0132
  contributor:
    fullname: Ravandi
– volume: 16
  start-page: 151
  year: 1994
  ident: key 20180328170405_cwx108C86
  article-title: Changes of monosaccharide availability of human hybridoma lead to alteration of biological properties of human monoclonal antibody
  publication-title: Cytotechnology
  doi: 10.1007/BF00749902
  contributor:
    fullname: Tachibana
– volume: 289
  start-page: 33481
  year: 2014
  ident: key 20180328170405_cwx108C48
  article-title: Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M114.593129
  contributor:
    fullname: Läubli
– volume: 271
  start-page: 281
  year: 2004
  ident: key 20180328170405_cwx108C83
  article-title: O-acetylation and de-O-acetylation of sialic acids in human colorectal carcinoma
  publication-title: Eur J Biochem
  doi: 10.1046/j.1432-1033.2003.03927.x
  contributor:
    fullname: Shen
– volume: 2
  start-page: 103
  year: 1984
  ident: key 20180328170405_cwx108C36
  article-title: Tumor-associated carbohydrate antigens
  publication-title: Annu Rev Immunol
  doi: 10.1146/annurev.iy.02.040184.000535
  contributor:
    fullname: Hakomori
– volume: 7
  start-page: 8771
  year: 2016
  ident: key 20180328170405_cwx108C63
  article-title: Tumor sialylation impedes T cell mediated anti-tumor responses while promoting tumor associated-regulatory T cells
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.6822
  contributor:
    fullname: Perdicchio
– volume: 53
  start-page: 208
  year: 2012
  ident: key 20180328170405_cwx108C22
  article-title: Targeting B lymphoma with nanoparticles bearing glycan ligands of CD22
  publication-title: Leuk Lymphoma
  doi: 10.3109/10428194.2011.604755
  contributor:
    fullname: Chen
– volume: 100
  start-page: 12045
  year: 2003
  ident: key 20180328170405_cwx108C88
  article-title: Human uptake and incorporation of an immunogenic nonhuman dietary sialic acid
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.2131556100
  contributor:
    fullname: Tangvoranuntakul
– volume: 16
  start-page: 24
  year: 2016
  ident: key 20180328170405_cwx108C74
  article-title: Regulation of airway inflammation by Siglec-8 and Siglec-9 sialoglycan ligand expression
  publication-title: Curr Opin Allergy Clin Immunol
  doi: 10.1097/ACI.0000000000000234
  contributor:
    fullname: Schleimer
– volume: 15
  start-page: 409
  year: 1975
  ident: key 20180328170405_cwx108C81
  article-title: Regression of spontaneous mammary tumors in dogs after injection of neuraminidase-treated tumor cells
  publication-title: Int J Cancer
  doi: 10.1002/ijc.2910150307
  contributor:
    fullname: Sedlacek
– volume: 112
  start-page: 542
  year: 2015
  ident: key 20180328170405_cwx108C71
  article-title: A red meat-derived glycan promotes inflammation and cancer progression
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1417508112
  contributor:
    fullname: Samraj
– volume: 17
  start-page: 485
  year: 2000
  ident: key 20180328170405_cwx108C73
  article-title: Achievements and challenges of sialic acid research
  publication-title: Glycoconj J
  doi: 10.1023/A:1011062223612
  contributor:
    fullname: Schauer
– volume: 206
  start-page: 1691
  year: 2009
  ident: key 20180328170405_cwx108C17
  article-title: Group B Streptococcus suppression of phagocyte functions by protein-mediated engagement of human Siglec-5
  publication-title: J Exp Med
  doi: 10.1084/jem.20090691
  contributor:
    fullname: Carlin
– volume: 27
  start-page: 657
  year: 2017
  ident: key 20180328170405_cwx108C101
  article-title: Siglec-8 and Siglec-9 binding specificities and endogenous airway ligand distributions and properties
  publication-title: Glycobiology
  doi: 10.1093/glycob/cwx026
  contributor:
    fullname: Yu
– volume: 24
  start-page: 818
  year: 2014
  ident: key 20180328170405_cwx108C19
  article-title: The interplay between Siglecs and sialylated pathogens
  publication-title: Glycobiology
  doi: 10.1093/glycob/cwu067
  contributor:
    fullname: Chang
– volume: 11
  start-page: 720
  year: 1993
  ident: key 20180328170405_cwx108C13
  article-title: Culture pH affects expression rates and glycosylation of recombinant mouse placental lactogen proteins by Chinese hamster ovary (CHO) cells
  publication-title: Biotechnology (N Y)
  contributor:
    fullname: Borys
– volume: 17
  start-page: 1273
  issue: 11
  year: 2016
  ident: key 20180328170405_cwx108C9
  article-title: The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9
  publication-title: Nat Immunol
  doi: 10.1038/ni.3552
  contributor:
    fullname: Beatson
– volume: 14
  start-page: 741
  year: 2013
  ident: key 20180328170405_cwx108C8
  article-title: T cell regulation mediated by interaction of soluble CD52 with the inhibitory receptor Siglec-10
  publication-title: Nat Immunol
  doi: 10.1038/ni.2610
  contributor:
    fullname: Bandala-Sanchez
– volume: 842
  start-page: 1
  year: 2015
  ident: key 20180328170405_cwx108C77
  article-title: Human-specific evolutionary changes in the biology of siglecs
  publication-title: Adv Exp Med Biol
  doi: 10.1007/978-3-319-11280-0_1
  contributor:
    fullname: Schwarz
– volume: 290
  start-page: 30066
  year: 2015
  ident: key 20180328170405_cwx108C53
  article-title: Unmasking of CD22 co-receptor on germinal center B-cells occurs by alternative mechanisms in mouse and man
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M115.691337
  contributor:
    fullname: Macauley
– volume: 2
  start-page: 170
  year: 2012
  ident: key 20180328170405_cwx108C95
  article-title: Anti-ganglioside anti-idiotypic vaccination: More than molecular mimicry
  publication-title: Front Oncol
  doi: 10.3389/fonc.2012.00170
  contributor:
    fullname: Vazquez
– volume: 19
  start-page: 810
  year: 2009
  ident: key 20180328170405_cwx108C92
  article-title: Natural ligands for CD33-related Siglecs?
  publication-title: Glycobiology
  doi: 10.1093/glycob/cwp063
  contributor:
    fullname: Varki
– volume: 113
  start-page: 3329
  year: 2016
  ident: key 20180328170405_cwx108C64
  article-title: Sialic acid-modified antigens impose tolerance via inhibition of T-cell proliferation and de novo induction of regulatory T cells
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1507706113
  contributor:
    fullname: Perdicchio
– volume: 5
  start-page: 526
  year: 2005
  ident: key 20180328170405_cwx108C34
  article-title: The sweet and sour of cancer: Glycans as novel therapeutic targets
  publication-title: Nat Rev Cancer
  doi: 10.1038/nrc1649
  contributor:
    fullname: Fuster
– volume: 124
  start-page: 1810
  year: 2014
  ident: key 20180328170405_cwx108C43
  article-title: Interactions between Siglec-7/9 receptors and ligands influence NK cell-dependent tumor immunosurveillance
  publication-title: J Clin Invest
  doi: 10.1172/JCI65899
  contributor:
    fullname: Jandus
– volume: 292
  start-page: 1029
  year: 2017
  ident: key 20180328170405_cwx108C84
  article-title: Studies on the detection, expression, glycosylation, dimerization, and ligand binding properties of mouse siglec-E
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M116.738351
  contributor:
    fullname: Siddiqui
– volume: 1143
  start-page: 61
  year: 2008
  ident: key 20180328170405_cwx108C96
  article-title: Basic and clinical immunology of Siglecs
  publication-title: Ann N Y Acad Sci
  doi: 10.1196/annals.1443.011
  contributor:
    fullname: von Gunten
– volume: 7
  start-page: 255
  year: 2007
  ident: key 20180328170405_cwx108C26
  article-title: Siglecs and their roles in the immune system
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri2056
  contributor:
    fullname: Crocker
– volume: 16
  start-page: 307
  year: 1999
  ident: key 20180328170405_cwx108C25
  article-title: Reduction of sialic acid O-acetylation in human colonic mucins in the adenoma-carcinoma sequence
  publication-title: Glycoconj J
  doi: 10.1023/A:1007026314792
  contributor:
    fullname: Corfield
– volume: 26
  start-page: 111
  issue: 2
  year: 2016
  ident: key 20180328170405_cwx108C62
  article-title: Sialic acids in cancer biology and immunity
  publication-title: Glycobiology
  doi: 10.1093/glycob/cwv097
  contributor:
    fullname: Pearce
– volume: 113
  start-page: 3333
  year: 2009
  ident: key 20180328170405_cwx108C18
  article-title: Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response
  publication-title: Blood
  doi: 10.1182/blood-2008-11-187302
  contributor:
    fullname: Carlin
– volume: 132
  start-page: 18
  year: 2011
  ident: key 20180328170405_cwx108C16
  article-title: Evolution of CD33-related siglecs: Regulating host immune functions and escaping pathogen exploitation?
  publication-title: Immunology
  doi: 10.1111/j.1365-2567.2010.03368.x
  contributor:
    fullname: Cao
– volume: 276
  start-page: 178
  year: 2017
  ident: key 20180328170405_cwx108C33
  article-title: Viewing Siglecs through the lens of tumor immunology
  publication-title: Immunol Rev
  doi: 10.1111/imr.12526
  contributor:
    fullname: Fraschilla
– volume: 30
  start-page: 357
  year: 2012
  ident: key 20180328170405_cwx108C65
  article-title: Siglecs and immune regulation
  publication-title: Annu Rev Immunol
  doi: 10.1146/annurev-immunol-020711-075018
  contributor:
    fullname: Pillai
– volume: 275
  start-page: 16666
  year: 2000
  ident: key 20180328170405_cwx108C32
  article-title: Factor H binding to bone sialoprotein and osteopontin enables tumor cell evasion of complement-mediated attack
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M001123200
  contributor:
    fullname: Fedarko
– volume: 105
  start-page: 18936
  year: 2008
  ident: key 20180328170405_cwx108C37
  article-title: Evidence for a human-specific mechanism for diet and antibody-mediated inflammation in carcinoma progression
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0803943105
  contributor:
    fullname: Hedlund
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Snippet Abstract Changes in sialic acids in cancer have been observed for many years. In particular, the increase of sialoglycan density or hypersialylation in tumors...
Changes in sialic acids in cancer have been observed for many years. In particular, the increase of sialoglycan density or hypersialylation in tumors has been...
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SubjectTerms Humans
Immune Tolerance - immunology
Immunity, Innate
Immunotherapy
N-Acetylneuraminic Acid - immunology
Neoplasms - immunology
Neoplasms - therapy
Sialic Acid Binding Immunoglobulin-like Lectins - immunology
Title Targeting sialic acid–Siglec interactions to reverse immune suppression in cancer
URI https://www.ncbi.nlm.nih.gov/pubmed/29309569
https://search.proquest.com/docview/1989558923
Volume 28
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