Baroreceptor unloading in postural tachycardia syndrome augments peripheral chemoreceptor sensitivity and decreases central chemoreceptor sensitivity

• Published in: American journal of physiology. Heart and circulatory physiology Vol. 301; no. 1; pp. H173 - H179
• Main Authors: Taneja, Indu, Medow, Marvin S., Clarke, Debbie A., Ocon, Anthony J., Stewart, Julian M.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.07.2011
• Subjects: Adolescent; Adult; Blood Pressure - physiology; Carbon dioxide; Cardiovascular Neurohormonal Regulation; Central Nervous System - physiopathology; Chemoreceptor Cells - physiology; Data Interpretation, Statistical; Female; Heart Rate - physiology; Humans; Hypercapnia - physiopathology; Hyperoxia; Hyperventilation - etiology; Hyperventilation - physiopathology; Hypoxia; Hypoxia - physiopathology; Male; Oxygen; Peripheral Nervous System - physiopathology; Postural Orthostatic Tachycardia Syndrome - complications; Postural Orthostatic Tachycardia Syndrome - physiopathology; Pressoreceptors - physiology; Ventilation; Young Adult

While orthostatic tachycardia is the hallmark of postural tachycardia syndrome (POTS), orthostasis also initiates increased minute ventilation (V̇e) and decreased end-tidal CO 2 in many patients. We hypothesized that chemoreflex sensitivity would be increased in patients with POTS. We therefore meas...