Network meta‐analysis of medical therapy efficacy in more than 90,000 patients with heart failure and reduced ejection fraction

• Published in: Journal of internal medicine Vol. 292; no. 2; pp. 333 - 349
• Main Authors: De Marzo, Vincenzo, Savarese, Gianluigi, Tricarico, Lucia, Hassan, Sofia, Iacoviello, Massimo, Porto, Italo, Ameri, Pietro
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.08.2022
• Subjects: Angiotensin; Angiotensin Receptor Antagonists - therapeutic use; Angiotensin-Converting Enzyme Inhibitors - therapeutic use; Bayesian analysis; Cardiovascular diseases; Clinical trials; Congestive heart failure; Drug therapy; Drugs; Ejection fraction; Enzyme inhibitors; Heart Failure; Humans; Meta-analysis; Mortality; Na+/glucose cotransporter; Neprilysin; outcomes; Patients; pharmacotherapy; prognosis; Receptors; Sensitivity analysis; Stroke Volume; Subgroups; Therapy; trial; Ventricle; Ventricular Dysfunction, Left; mortality; heart failure; outcomes; prognosis; pharmacotherapy; trial

Background Following the availability of new drugs for chronic heart failure (HF) with reduced ejection fraction (HFrEF), we sought to provide an updated and comparative synthesis of the evidence on HFrEF pharmacotherapy efficacy. Methods We performed a Bayesian network meta‐analysis of phase 2 and...