Superparamagnetic iron oxides and low molecular weight gadolinium chelates are synergistic for direct visualization of advanced liver fibrosis

Purpose To compare the contrast‐to‐noise ratio (CNR) of advanced liver fibrosis on nonenhanced (NE), gadolinium enhanced (Gd), superparamagnetic iron oxides enhanced (SPIO), and combined contrast‐enhanced (CCE) spoiled gradient echoes (SGEs). Materials and Methods This retrospective study assessed 8...

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Published inJournal of magnetic resonance imaging Vol. 26; no. 3; pp. 728 - 737
Main Authors Hughes-Cassidy, Fiona, Chavez, Alyssa D., Schlang, Adrienne, Hassanein, Tarek, Gamst, Anthony, Wolfson, Tanya, Sirlin, Claude
Format Journal Article
LanguageEnglish
Published Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.09.2007
Subjects
Adult
Aged
Aged, 80 and over
Chelating Agents - pharmacology
contrast agents
Contrast Media - pharmacology
Female
Ferric Compounds - pharmacology
fibrosis
Gadolinium - pharmacology
Humans
liver
Liver Cirrhosis - diagnosis
Liver Cirrhosis - pathology
Liver Transplantation
magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Middle Aged
Retrospective Studies
Surface Properties
Online AccessGet full text
ISSN1053-1807
1522-2586
DOI10.1002/jmri.21066

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Abstract Purpose To compare the contrast‐to‐noise ratio (CNR) of advanced liver fibrosis on nonenhanced (NE), gadolinium enhanced (Gd), superparamagnetic iron oxides enhanced (SPIO), and combined contrast‐enhanced (CCE) spoiled gradient echoes (SGEs). Materials and Methods This retrospective study assessed 83 consecutive patients with cirrhosis and 10 consecutive patients without fibrosis. All patients had NE, Gd, SPIO, and CCE images at 1.5T. A total of six breathhold SGE sequences with varying imaging parameters were assessed. MR images were evaluated qualitatively and, in 15 cirrhotics who underwent liver transplantation, compared to gross pathology. CNR of fibrosis to background liver was compared across sequences and contrast enhancement types. Results In cirrhotic patients, CCE images on all sequences showed fibrosis as a meshwork of high‐signal 1‐mm to 3‐mm thick reticulations surrounding 2‐mm to 5‐mm low‐signal regenerative nodules. Fibrosis was less visible on Gd and SPIO images and was barely visible on NE images. CNR was significantly higher for CCE than for NE, Gd, or SPIO images in eight of nine comparisons (P < 0.0001–0.05). The liver had a homogeneous appearance in subjects without fibrosis. Conclusion CCE imaging depicts advanced liver fibrosis with higher CNR than NE, Gd, or SPIO SGEs. J. Magn. Reson. Imaging 2007. © 2007 Wiley‐Liss, Inc.
AbstractList To compare the contrast-to-noise ratio (CNR) of advanced liver fibrosis on nonenhanced (NE), gadolinium enhanced (Gd), superparamagnetic iron oxides enhanced (SPIO), and combined contrast-enhanced (CCE) spoiled gradient echoes (SGEs). This retrospective study assessed 83 consecutive patients with cirrhosis and 10 consecutive patients without fibrosis. All patients had NE, Gd, SPIO, and CCE images at 1.5 T. A total of six breathhold SGE sequences with varying imaging parameters were assessed. MR images were evaluated qualitatively and, in 15 cirrhotics who underwent liver transplantation, compared to gross pathology. CNR of fibrosis to background liver was compared across sequences and contrast enhancement types. In cirrhotic patients, CCE images on all sequences showed fibrosis as a meshwork of high-signal 1-mm to 3-mm thick reticulations surrounding 2-mm to 5-mm low-signal regenerative nodules. Fibrosis was less visible on Gd and SPIO images and was barely visible on NE images. CNR was significantly higher for CCE than for NE, Gd, or SPIO images in eight of nine comparisons (P < 0.0001-0.05). The liver had a homogeneous appearance in subjects without fibrosis. CCE imaging depicts advanced liver fibrosis with higher CNR than NE, Gd, or SPIO SGEs.
To compare the contrast-to-noise ratio (CNR) of advanced liver fibrosis on nonenhanced (NE), gadolinium enhanced (Gd), superparamagnetic iron oxides enhanced (SPIO), and combined contrast-enhanced (CCE) spoiled gradient echoes (SGEs).PURPOSETo compare the contrast-to-noise ratio (CNR) of advanced liver fibrosis on nonenhanced (NE), gadolinium enhanced (Gd), superparamagnetic iron oxides enhanced (SPIO), and combined contrast-enhanced (CCE) spoiled gradient echoes (SGEs).This retrospective study assessed 83 consecutive patients with cirrhosis and 10 consecutive patients without fibrosis. All patients had NE, Gd, SPIO, and CCE images at 1.5 T. A total of six breathhold SGE sequences with varying imaging parameters were assessed. MR images were evaluated qualitatively and, in 15 cirrhotics who underwent liver transplantation, compared to gross pathology. CNR of fibrosis to background liver was compared across sequences and contrast enhancement types.MATERIALS AND METHODSThis retrospective study assessed 83 consecutive patients with cirrhosis and 10 consecutive patients without fibrosis. All patients had NE, Gd, SPIO, and CCE images at 1.5 T. A total of six breathhold SGE sequences with varying imaging parameters were assessed. MR images were evaluated qualitatively and, in 15 cirrhotics who underwent liver transplantation, compared to gross pathology. CNR of fibrosis to background liver was compared across sequences and contrast enhancement types.In cirrhotic patients, CCE images on all sequences showed fibrosis as a meshwork of high-signal 1-mm to 3-mm thick reticulations surrounding 2-mm to 5-mm low-signal regenerative nodules. Fibrosis was less visible on Gd and SPIO images and was barely visible on NE images. CNR was significantly higher for CCE than for NE, Gd, or SPIO images in eight of nine comparisons (P < 0.0001-0.05). The liver had a homogeneous appearance in subjects without fibrosis.RESULTSIn cirrhotic patients, CCE images on all sequences showed fibrosis as a meshwork of high-signal 1-mm to 3-mm thick reticulations surrounding 2-mm to 5-mm low-signal regenerative nodules. Fibrosis was less visible on Gd and SPIO images and was barely visible on NE images. CNR was significantly higher for CCE than for NE, Gd, or SPIO images in eight of nine comparisons (P < 0.0001-0.05). The liver had a homogeneous appearance in subjects without fibrosis.CCE imaging depicts advanced liver fibrosis with higher CNR than NE, Gd, or SPIO SGEs.CONCLUSIONCCE imaging depicts advanced liver fibrosis with higher CNR than NE, Gd, or SPIO SGEs.
Purpose To compare the contrast‐to‐noise ratio (CNR) of advanced liver fibrosis on nonenhanced (NE), gadolinium enhanced (Gd), superparamagnetic iron oxides enhanced (SPIO), and combined contrast‐enhanced (CCE) spoiled gradient echoes (SGEs). Materials and Methods This retrospective study assessed 83 consecutive patients with cirrhosis and 10 consecutive patients without fibrosis. All patients had NE, Gd, SPIO, and CCE images at 1.5T. A total of six breathhold SGE sequences with varying imaging parameters were assessed. MR images were evaluated qualitatively and, in 15 cirrhotics who underwent liver transplantation, compared to gross pathology. CNR of fibrosis to background liver was compared across sequences and contrast enhancement types. Results In cirrhotic patients, CCE images on all sequences showed fibrosis as a meshwork of high‐signal 1‐mm to 3‐mm thick reticulations surrounding 2‐mm to 5‐mm low‐signal regenerative nodules. Fibrosis was less visible on Gd and SPIO images and was barely visible on NE images. CNR was significantly higher for CCE than for NE, Gd, or SPIO images in eight of nine comparisons (P < 0.0001–0.05). The liver had a homogeneous appearance in subjects without fibrosis. Conclusion CCE imaging depicts advanced liver fibrosis with higher CNR than NE, Gd, or SPIO SGEs. J. Magn. Reson. Imaging 2007. © 2007 Wiley‐Liss, Inc.
Author Hassanein, Tarek
Schlang, Adrienne
Wolfson, Tanya
Gamst, Anthony
Sirlin, Claude
Chavez, Alyssa D.
Hughes-Cassidy, Fiona
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Snippet Purpose To compare the contrast‐to‐noise ratio (CNR) of advanced liver fibrosis on nonenhanced (NE), gadolinium enhanced (Gd), superparamagnetic iron oxides...
To compare the contrast-to-noise ratio (CNR) of advanced liver fibrosis on nonenhanced (NE), gadolinium enhanced (Gd), superparamagnetic iron oxides enhanced...
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SubjectTerms Adult
Aged
Aged, 80 and over
Chelating Agents - pharmacology
contrast agents
Contrast Media - pharmacology
Female
Ferric Compounds - pharmacology
fibrosis
Gadolinium - pharmacology
Humans
liver
Liver Cirrhosis - diagnosis
Liver Cirrhosis - pathology
Liver Transplantation
magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Middle Aged
Retrospective Studies
Surface Properties
Title Superparamagnetic iron oxides and low molecular weight gadolinium chelates are synergistic for direct visualization of advanced liver fibrosis
URI https://api.istex.fr/ark:/67375/WNG-0FZRGC9B-Q/fulltext.pdf
https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fjmri.21066
https://www.ncbi.nlm.nih.gov/pubmed/17685418
https://www.proquest.com/docview/68232338
Volume 26
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